Electrospun Nanofiber Platforms for Photodynamic Therapy: Role and Efficacy in Cancer, Antimicrobial, and Wound Healing Applications
Abstract Electrospinning offers a versatile platform for developing nanofibrous scaffolds capable of enhancing the therapeutic potential of photodynamic therapy (PDT). Photosensitizer (PS) loaded fibers exhibit a high surface area‐to‐volume ratio, promoting efficient drug delivery, prolonged retenti...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2025-05-01
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| Series: | Macromolecular Materials and Engineering |
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| Online Access: | https://doi.org/10.1002/mame.202500014 |
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| author | Aslı Eldem Yamaç Tekintaş Muhammed Ucuncu Nesrin Horzum |
| author_facet | Aslı Eldem Yamaç Tekintaş Muhammed Ucuncu Nesrin Horzum |
| author_sort | Aslı Eldem |
| collection | DOAJ |
| description | Abstract Electrospinning offers a versatile platform for developing nanofibrous scaffolds capable of enhancing the therapeutic potential of photodynamic therapy (PDT). Photosensitizer (PS) loaded fibers exhibit a high surface area‐to‐volume ratio, promoting efficient drug delivery, prolonged retention at the target site, and controlled release profiles. Inducing reactive oxygen species (ROS) generation through light activation offers a targeted therapeutic approach, selectively generating cytotoxic effects in cancerous or pathogenic cells while minimizing damage to healthy tissue. This selective cytotoxicity arises because the ROS are produced only in illuminated areas where PS releases and accumulates, limiting their harmful effects to desired regions. Additionally, PS‐loaded fibers are highly effective in wound healing applications, promoting cell proliferation and tissue regeneration while providing a barrier against microbial infections. This review highlights recent advances in the design and biomedical application of PS‐loaded nanofibers, emphasizing their influence on cell viability and effectiveness in microbial inhibition, thereby setting the stage for future innovations in cancer therapy, wound healing, and infection control. |
| format | Article |
| id | doaj-art-49b72bcde5af4264bb08487ff7cefcaa |
| institution | OA Journals |
| issn | 1438-7492 1439-2054 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Macromolecular Materials and Engineering |
| spelling | doaj-art-49b72bcde5af4264bb08487ff7cefcaa2025-08-20T02:31:43ZengWiley-VCHMacromolecular Materials and Engineering1438-74921439-20542025-05-013105n/an/a10.1002/mame.202500014Electrospun Nanofiber Platforms for Photodynamic Therapy: Role and Efficacy in Cancer, Antimicrobial, and Wound Healing ApplicationsAslı Eldem0Yamaç Tekintaş1Muhammed Ucuncu2Nesrin Horzum3Department of Analytical Chemistry, Faculty of Pharmacyİzmir Katip,Çelebi Universityİzmir 35620 TürkiyeDepartment of Pharmaceutical Microbiology, Faculty of Pharmacyİzmir Katip Çelebi Universityİzmir 35620 TürkiyeDepartment of Analytical Chemistry, Faculty of Pharmacyİzmir Katip,Çelebi Universityİzmir 35620 TürkiyeDepartment of Engineering Sciences, Faculty of Engineering and Architectureİzmir Katip Çelebi Universityİzmir 35620 TürkiyeAbstract Electrospinning offers a versatile platform for developing nanofibrous scaffolds capable of enhancing the therapeutic potential of photodynamic therapy (PDT). Photosensitizer (PS) loaded fibers exhibit a high surface area‐to‐volume ratio, promoting efficient drug delivery, prolonged retention at the target site, and controlled release profiles. Inducing reactive oxygen species (ROS) generation through light activation offers a targeted therapeutic approach, selectively generating cytotoxic effects in cancerous or pathogenic cells while minimizing damage to healthy tissue. This selective cytotoxicity arises because the ROS are produced only in illuminated areas where PS releases and accumulates, limiting their harmful effects to desired regions. Additionally, PS‐loaded fibers are highly effective in wound healing applications, promoting cell proliferation and tissue regeneration while providing a barrier against microbial infections. This review highlights recent advances in the design and biomedical application of PS‐loaded nanofibers, emphasizing their influence on cell viability and effectiveness in microbial inhibition, thereby setting the stage for future innovations in cancer therapy, wound healing, and infection control.https://doi.org/10.1002/mame.202500014electrospinningnanocarrierphotoactive nanofiberphotodynamic therapyphotothermal therapy |
| spellingShingle | Aslı Eldem Yamaç Tekintaş Muhammed Ucuncu Nesrin Horzum Electrospun Nanofiber Platforms for Photodynamic Therapy: Role and Efficacy in Cancer, Antimicrobial, and Wound Healing Applications Macromolecular Materials and Engineering electrospinning nanocarrier photoactive nanofiber photodynamic therapy photothermal therapy |
| title | Electrospun Nanofiber Platforms for Photodynamic Therapy: Role and Efficacy in Cancer, Antimicrobial, and Wound Healing Applications |
| title_full | Electrospun Nanofiber Platforms for Photodynamic Therapy: Role and Efficacy in Cancer, Antimicrobial, and Wound Healing Applications |
| title_fullStr | Electrospun Nanofiber Platforms for Photodynamic Therapy: Role and Efficacy in Cancer, Antimicrobial, and Wound Healing Applications |
| title_full_unstemmed | Electrospun Nanofiber Platforms for Photodynamic Therapy: Role and Efficacy in Cancer, Antimicrobial, and Wound Healing Applications |
| title_short | Electrospun Nanofiber Platforms for Photodynamic Therapy: Role and Efficacy in Cancer, Antimicrobial, and Wound Healing Applications |
| title_sort | electrospun nanofiber platforms for photodynamic therapy role and efficacy in cancer antimicrobial and wound healing applications |
| topic | electrospinning nanocarrier photoactive nanofiber photodynamic therapy photothermal therapy |
| url | https://doi.org/10.1002/mame.202500014 |
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