Duodenogastral reflux and its influence on manifestation of morphological changes of gastric mucosa
Among the diseases of the gastroduodenal zone chronic gastritis (CG) occupies one of the leading positions. One of the main forms of CG is reflux gastritis (RG) based on long-term location of duodenal content in the gastric antrum, so-called duodenal reflux (DR). It is well known that stable inflamm...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dnipro State Medical University
2015-09-01
|
| Series: | Medičnì Perspektivi |
| Subjects: | |
| Online Access: | http://medpers.dsma.dp.ua/issues/2015/N3/21-26.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850084477716398080 |
|---|---|
| author | Stepanov Yu.M. Kovalenko A.N. Salenko А.V. |
| author_facet | Stepanov Yu.M. Kovalenko A.N. Salenko А.V. |
| author_sort | Stepanov Yu.M. |
| collection | DOAJ |
| description | Among the diseases of the gastroduodenal zone chronic gastritis (CG) occupies one of the leading positions. One of the main forms of CG is reflux gastritis (RG) based on long-term location of duodenal content in the gastric antrum, so-called duodenal reflux (DR). It is well known that stable inflammatory response of the gastric mucosa (GM) appears under the influence of bile acid and gastric juice, leading to chronic antral gastritis followed by gradual development of atrophy, metaplasia and dysplasia appearance. Therefore the aim of our work was to investigate the influence of the DR on the course of chronic hepatitis and morphological changes in the gastric mucosa. We observed 70 patients with chronic RG, aged from 22 to 59 years, average age – 43,5±1,2 years. The control group consisted of 25 healthy individuals of both sexes aged from 19 to 39 years. As a result it was found out that pain and dyspeptic syndromes caused problems most of all. While studying the content of bile acids in gastric juice of all patients examined it was higher (1,42±0,05 g/L) in comparison with the control group (0,65±0,04 g/L). Content of bile acids in groups of RG patients with atrophy and without it was analyzed. The role of DR as an independent factor of recomposing changes in GM in chronic RG was proved. |
| format | Article |
| id | doaj-art-49b72571df034e55834b0ae7c90ab470 |
| institution | DOAJ |
| issn | 2307-0404 2307-0404 |
| language | English |
| publishDate | 2015-09-01 |
| publisher | Dnipro State Medical University |
| record_format | Article |
| series | Medičnì Perspektivi |
| spelling | doaj-art-49b72571df034e55834b0ae7c90ab4702025-08-20T02:44:02ZengDnipro State Medical UniversityMedičnì Perspektivi2307-04042307-04042015-09-012032126Duodenogastral reflux and its influence on manifestation of morphological changes of gastric mucosaStepanov Yu.M.0Kovalenko A.N.1Salenko А.V. 2SI «Institute of Gastroenterology of National Academy of Medical Sciences of Ukraine»SI «Railway Hospital» of State Enterprise «Odessa Railway»SE «Dnipropetrovsk medical academy of Health Ministry of Ukraine»Among the diseases of the gastroduodenal zone chronic gastritis (CG) occupies one of the leading positions. One of the main forms of CG is reflux gastritis (RG) based on long-term location of duodenal content in the gastric antrum, so-called duodenal reflux (DR). It is well known that stable inflammatory response of the gastric mucosa (GM) appears under the influence of bile acid and gastric juice, leading to chronic antral gastritis followed by gradual development of atrophy, metaplasia and dysplasia appearance. Therefore the aim of our work was to investigate the influence of the DR on the course of chronic hepatitis and morphological changes in the gastric mucosa. We observed 70 patients with chronic RG, aged from 22 to 59 years, average age – 43,5±1,2 years. The control group consisted of 25 healthy individuals of both sexes aged from 19 to 39 years. As a result it was found out that pain and dyspeptic syndromes caused problems most of all. While studying the content of bile acids in gastric juice of all patients examined it was higher (1,42±0,05 g/L) in comparison with the control group (0,65±0,04 g/L). Content of bile acids in groups of RG patients with atrophy and without it was analyzed. The role of DR as an independent factor of recomposing changes in GM in chronic RG was proved.http://medpers.dsma.dp.ua/issues/2015/N3/21-26.pdfchronic gastritisduodenogastral refluxbile acids |
| spellingShingle | Stepanov Yu.M. Kovalenko A.N. Salenko А.V. Duodenogastral reflux and its influence on manifestation of morphological changes of gastric mucosa Medičnì Perspektivi chronic gastritis duodenogastral reflux bile acids |
| title | Duodenogastral reflux and its influence on manifestation of morphological changes of gastric mucosa |
| title_full | Duodenogastral reflux and its influence on manifestation of morphological changes of gastric mucosa |
| title_fullStr | Duodenogastral reflux and its influence on manifestation of morphological changes of gastric mucosa |
| title_full_unstemmed | Duodenogastral reflux and its influence on manifestation of morphological changes of gastric mucosa |
| title_short | Duodenogastral reflux and its influence on manifestation of morphological changes of gastric mucosa |
| title_sort | duodenogastral reflux and its influence on manifestation of morphological changes of gastric mucosa |
| topic | chronic gastritis duodenogastral reflux bile acids |
| url | http://medpers.dsma.dp.ua/issues/2015/N3/21-26.pdf |
| work_keys_str_mv | AT stepanovyum duodenogastralrefluxanditsinfluenceonmanifestationofmorphologicalchangesofgastricmucosa AT kovalenkoan duodenogastralrefluxanditsinfluenceonmanifestationofmorphologicalchangesofgastricmucosa AT salenkoav duodenogastralrefluxanditsinfluenceonmanifestationofmorphologicalchangesofgastricmucosa |