Treatment options applied to the preclinical studies using animal models for Chagas Disease: a systematic review and meta-analysis [version 3; peer review: 2 approved]
Background Chagas disease (CD) is a neglected tropical disease endemic to Latin America, has emerged as a global health concern due to the migration of infected individuals. With its epidemiological complexity, by difficulty to obtain appropriate diagnoses and poor treatment, the search for novel th...
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F1000 Research Ltd
2025-05-01
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| author | Haruna Luz Barazorda-Ccahuana Mayron Antonio Candia-Puma Miguel Angel Chavez-Fumagalli Luis Daniel Goyzueta-Mamani Rodolfo Cordeiro Cordeiro Giunchetti Ricardo Andrez Machado-de-Ávila Alexsandro Sobreira Galdino Brychs Milagros Roque-Pumahuanca Eduardo Antonio Ferraz Coelho Laura Yesenia Machaca-Luque |
| author_facet | Haruna Luz Barazorda-Ccahuana Mayron Antonio Candia-Puma Miguel Angel Chavez-Fumagalli Luis Daniel Goyzueta-Mamani Rodolfo Cordeiro Cordeiro Giunchetti Ricardo Andrez Machado-de-Ávila Alexsandro Sobreira Galdino Brychs Milagros Roque-Pumahuanca Eduardo Antonio Ferraz Coelho Laura Yesenia Machaca-Luque |
| author_sort | Haruna Luz Barazorda-Ccahuana |
| collection | DOAJ |
| description | Background Chagas disease (CD) is a neglected tropical disease endemic to Latin America, has emerged as a global health concern due to the migration of infected individuals. With its epidemiological complexity, by difficulty to obtain appropriate diagnoses and poor treatment, the search for novel therapeutic options remains. Methods In this context, we conducted a systematic review and meta-analysis of preclinical studies employing animal models to verify the progress in CD treatment. We searched the PubMed database for CD treatment studies published between 1990 and 2023, adhering to the PRISMA guidelines. Results Twelve papers met the inclusion criteria. The findings indicate that the fifteen treatment alternatives examined, mainly between 2010 and 2014, demonstrated efficacy in experimental CD models, evidenced by significant parasitemia reduction. Bis-triazole DO870 and VNI were effective in the acute and chronic phases, respectively. However, of these emerging therapies, only posaconazole and fexinidazole have progressed to clinical trials, yielding unsatisfactory outcomes as CD monotherapies Conclusions This meta-analysis highlights the existence of promising new drug candidates for CD treatment, but most remain in the preclinical stages. Those that reached clinical trials did not demonstrate optimal results, underscoring the ongoing challenges in CD therapy. Collaborative efforts among the academic community, pharmaceutical industries, funding agencies, and government agencies are urgently needed to accelerate the development of more effective medications against CD. Inplasy registration INPLASY202430101 (25/03/2024) |
| format | Article |
| id | doaj-art-49b67fa2d0224899a6db95749b1c05cf |
| institution | DOAJ |
| issn | 2046-1402 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj-art-49b67fa2d0224899a6db95749b1c05cf2025-08-20T03:12:54ZengF1000 Research LtdF1000Research2046-14022025-05-011310.12688/f1000research.150723.3182003Treatment options applied to the preclinical studies using animal models for Chagas Disease: a systematic review and meta-analysis [version 3; peer review: 2 approved]Haruna Luz Barazorda-Ccahuana0https://orcid.org/0000-0001-8791-0506Mayron Antonio Candia-Puma1https://orcid.org/0000-0002-6328-3840Miguel Angel Chavez-Fumagalli2https://orcid.org/0000-0002-8394-4802Luis Daniel Goyzueta-Mamani3https://orcid.org/0000-0003-0308-1160Rodolfo Cordeiro Cordeiro Giunchetti4Ricardo Andrez Machado-de-Ávila5Alexsandro Sobreira Galdino6Brychs Milagros Roque-Pumahuanca7Eduardo Antonio Ferraz Coelho8Laura Yesenia Machaca-Luque9Computational Biology and Chemistry Research Group, Vicerrectorado de Investigación, Universidad Católica de Santa María, Pedro Vilcapaza, Arequipa, 04000, PeruComputational Biology and Chemistry Research Group, Vicerrectorado de Investigación, Universidad Católica de Santa María, Pedro Vilcapaza, Arequipa, 04000, PeruComputational Biology and Chemistry Research Group, Vicerrectorado de Investigación, Universidad Católica de Santa María, Pedro Vilcapaza, Arequipa, 04000, PeruComputational Biology and Chemistry Research Group, Vicerrectorado de Investigación, Universidad Católica de Santa María, Pedro Vilcapaza, Arequipa, 04000, PeruLaboratório de Biologia das Interações Celulares, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, State of Minas Gerais, 31270-901, BrazilPrograma de Pós-Graduação em Ciências da Saúde, University of the Extreme South of Santa Catarina, Criciúma, State of Santa Catarina, 88806-000, BrazilLaboratório de Biotecnologia de Microrganismos, , MG e Instituto Nacional de Ciência e Tecnologia em Biotecnologia Industrial, Universidade Federal de Sao Joao del-Rei, Divinópolis, State of Minas Gerais, 35501-296, BrazilComputational Biology and Chemistry Research Group, Vicerrectorado de Investigación, Universidad Católica de Santa María, Pedro Vilcapaza, Arequipa, 04000, PeruPrograma de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina,, Universidade Federal de Minas Gerais, Belo Horizonte, State of Minas Gerais, 31270-901, BrazilComputational Biology and Chemistry Research Group, Vicerrectorado de Investigación, Universidad Católica de Santa María, Pedro Vilcapaza, Arequipa, 04000, PeruBackground Chagas disease (CD) is a neglected tropical disease endemic to Latin America, has emerged as a global health concern due to the migration of infected individuals. With its epidemiological complexity, by difficulty to obtain appropriate diagnoses and poor treatment, the search for novel therapeutic options remains. Methods In this context, we conducted a systematic review and meta-analysis of preclinical studies employing animal models to verify the progress in CD treatment. We searched the PubMed database for CD treatment studies published between 1990 and 2023, adhering to the PRISMA guidelines. Results Twelve papers met the inclusion criteria. The findings indicate that the fifteen treatment alternatives examined, mainly between 2010 and 2014, demonstrated efficacy in experimental CD models, evidenced by significant parasitemia reduction. Bis-triazole DO870 and VNI were effective in the acute and chronic phases, respectively. However, of these emerging therapies, only posaconazole and fexinidazole have progressed to clinical trials, yielding unsatisfactory outcomes as CD monotherapies Conclusions This meta-analysis highlights the existence of promising new drug candidates for CD treatment, but most remain in the preclinical stages. Those that reached clinical trials did not demonstrate optimal results, underscoring the ongoing challenges in CD therapy. Collaborative efforts among the academic community, pharmaceutical industries, funding agencies, and government agencies are urgently needed to accelerate the development of more effective medications against CD. Inplasy registration INPLASY202430101 (25/03/2024)https://f1000research.com/articles/13-885/v3Chagas disease treatment efficacy systematic review meta-analysis parasitemiaeng |
| spellingShingle | Haruna Luz Barazorda-Ccahuana Mayron Antonio Candia-Puma Miguel Angel Chavez-Fumagalli Luis Daniel Goyzueta-Mamani Rodolfo Cordeiro Cordeiro Giunchetti Ricardo Andrez Machado-de-Ávila Alexsandro Sobreira Galdino Brychs Milagros Roque-Pumahuanca Eduardo Antonio Ferraz Coelho Laura Yesenia Machaca-Luque Treatment options applied to the preclinical studies using animal models for Chagas Disease: a systematic review and meta-analysis [version 3; peer review: 2 approved] F1000Research Chagas disease treatment efficacy systematic review meta-analysis parasitemia eng |
| title | Treatment options applied to the preclinical studies using animal models for Chagas Disease: a systematic review and meta-analysis [version 3; peer review: 2 approved] |
| title_full | Treatment options applied to the preclinical studies using animal models for Chagas Disease: a systematic review and meta-analysis [version 3; peer review: 2 approved] |
| title_fullStr | Treatment options applied to the preclinical studies using animal models for Chagas Disease: a systematic review and meta-analysis [version 3; peer review: 2 approved] |
| title_full_unstemmed | Treatment options applied to the preclinical studies using animal models for Chagas Disease: a systematic review and meta-analysis [version 3; peer review: 2 approved] |
| title_short | Treatment options applied to the preclinical studies using animal models for Chagas Disease: a systematic review and meta-analysis [version 3; peer review: 2 approved] |
| title_sort | treatment options applied to the preclinical studies using animal models for chagas disease a systematic review and meta analysis version 3 peer review 2 approved |
| topic | Chagas disease treatment efficacy systematic review meta-analysis parasitemia eng |
| url | https://f1000research.com/articles/13-885/v3 |
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