Advancing cancer research through organoid technology
Abstract The complexity of tumors and the challenges associated with treatment often stem from the limitations of existing models in accurately replicating authentic tumors. Recently, organoid technology has emerged as an innovative platform for tumor research. This bioengineering approach enables r...
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| Format: | Article |
| Language: | English |
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BMC
2024-11-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-024-05824-1 |
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| author | Guolong Zeng Yifan Yu Meiting Wang Jiaxing Liu Guangpeng He Sixuan Yu Huining Yan Liang Yang Hangyu Li Xueqiang Peng |
| author_facet | Guolong Zeng Yifan Yu Meiting Wang Jiaxing Liu Guangpeng He Sixuan Yu Huining Yan Liang Yang Hangyu Li Xueqiang Peng |
| author_sort | Guolong Zeng |
| collection | DOAJ |
| description | Abstract The complexity of tumors and the challenges associated with treatment often stem from the limitations of existing models in accurately replicating authentic tumors. Recently, organoid technology has emerged as an innovative platform for tumor research. This bioengineering approach enables researchers to simulate, in vitro, the interactions between tumors and their microenvironment, thereby enhancing the intricate interplay between tumor cells and their surroundings. Organoids also integrate multidimensional data, providing a novel paradigm for understanding tumor development and progression while facilitating precision therapy. Furthermore, advancements in imaging and genetic editing techniques have significantly augmented the potential of organoids in tumor research. This review explores the application of organoid technology for more precise tumor simulations and its specific contributions to cancer research advancements. Additionally, we discuss the challenges and evolving trends in developing comprehensive tumor models utilizing organoid technology. |
| format | Article |
| id | doaj-art-49b3e81a56da44db99e39b8cc217b1cd |
| institution | DOAJ |
| issn | 1479-5876 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj-art-49b3e81a56da44db99e39b8cc217b1cd2025-08-20T02:50:08ZengBMCJournal of Translational Medicine1479-58762024-11-0122111710.1186/s12967-024-05824-1Advancing cancer research through organoid technologyGuolong Zeng0Yifan Yu1Meiting Wang2Jiaxing Liu3Guangpeng He4Sixuan Yu5Huining Yan6Liang Yang7Hangyu Li8Xueqiang Peng9Department of General Surgery, The Fourth Affiliated Hospital, China Medical UniversityDepartment of General Surgery, The Fourth Affiliated Hospital, China Medical UniversityDepartment of General Surgery, The Fourth Affiliated Hospital, China Medical UniversityDepartment of General Surgery, The Fourth Affiliated Hospital, China Medical UniversityDepartment of General Surgery, The Fourth Affiliated Hospital, China Medical UniversityDepartment of General Surgery, The Fourth Affiliated Hospital, China Medical UniversityDepartment of General Surgery, The Fourth Affiliated Hospital, China Medical UniversityDepartment of General Surgery, The Fourth Affiliated Hospital, China Medical UniversityDepartment of General Surgery, The Fourth Affiliated Hospital, China Medical UniversityDepartment of General Surgery, The Fourth Affiliated Hospital, China Medical UniversityAbstract The complexity of tumors and the challenges associated with treatment often stem from the limitations of existing models in accurately replicating authentic tumors. Recently, organoid technology has emerged as an innovative platform for tumor research. This bioengineering approach enables researchers to simulate, in vitro, the interactions between tumors and their microenvironment, thereby enhancing the intricate interplay between tumor cells and their surroundings. Organoids also integrate multidimensional data, providing a novel paradigm for understanding tumor development and progression while facilitating precision therapy. Furthermore, advancements in imaging and genetic editing techniques have significantly augmented the potential of organoids in tumor research. This review explores the application of organoid technology for more precise tumor simulations and its specific contributions to cancer research advancements. Additionally, we discuss the challenges and evolving trends in developing comprehensive tumor models utilizing organoid technology.https://doi.org/10.1186/s12967-024-05824-1Tumor organoidsIn vitro modelingTumor microenvironmentMulti-omics analysisGene editingPrecision medicine |
| spellingShingle | Guolong Zeng Yifan Yu Meiting Wang Jiaxing Liu Guangpeng He Sixuan Yu Huining Yan Liang Yang Hangyu Li Xueqiang Peng Advancing cancer research through organoid technology Journal of Translational Medicine Tumor organoids In vitro modeling Tumor microenvironment Multi-omics analysis Gene editing Precision medicine |
| title | Advancing cancer research through organoid technology |
| title_full | Advancing cancer research through organoid technology |
| title_fullStr | Advancing cancer research through organoid technology |
| title_full_unstemmed | Advancing cancer research through organoid technology |
| title_short | Advancing cancer research through organoid technology |
| title_sort | advancing cancer research through organoid technology |
| topic | Tumor organoids In vitro modeling Tumor microenvironment Multi-omics analysis Gene editing Precision medicine |
| url | https://doi.org/10.1186/s12967-024-05824-1 |
| work_keys_str_mv | AT guolongzeng advancingcancerresearchthroughorganoidtechnology AT yifanyu advancingcancerresearchthroughorganoidtechnology AT meitingwang advancingcancerresearchthroughorganoidtechnology AT jiaxingliu advancingcancerresearchthroughorganoidtechnology AT guangpenghe advancingcancerresearchthroughorganoidtechnology AT sixuanyu advancingcancerresearchthroughorganoidtechnology AT huiningyan advancingcancerresearchthroughorganoidtechnology AT liangyang advancingcancerresearchthroughorganoidtechnology AT hangyuli advancingcancerresearchthroughorganoidtechnology AT xueqiangpeng advancingcancerresearchthroughorganoidtechnology |