Population pharmacokinetics of teicoplanin and dosage optimization in sepsis patients based on continuous renal replacement therapy
PurposeIt is well known that pharmacokinetics (PK) of drugs is significantly altered in sepsis patients receiving continuous renal replacement therapy (CRRT). However, clinical studies investigating the PK of drugs administered during CRRT are limited, and appropriate dosing regimens have not yet to...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1621959/full |
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| author | Qian Sun Jiang Jian Xueqiang Zhou Zhu Hong Suwen Yang Yanping Zheng Siyi Wang Maojun Zhao |
| author_facet | Qian Sun Jiang Jian Xueqiang Zhou Zhu Hong Suwen Yang Yanping Zheng Siyi Wang Maojun Zhao |
| author_sort | Qian Sun |
| collection | DOAJ |
| description | PurposeIt is well known that pharmacokinetics (PK) of drugs is significantly altered in sepsis patients receiving continuous renal replacement therapy (CRRT). However, clinical studies investigating the PK of drugs administered during CRRT are limited, and appropriate dosing regimens have not yet to be definitively established. The study aimed to develop a population PK model for teicoplanin, explore significant covariates regarding to teicoplanin PK, and propose optimal dosage strategies for sepsis patients.MethodsEighty-six sepsis patients were included and plasma samples from all patients were analyzed. PK analysis was conducted on samples from 86 sepsis patients, followed by population PK analysis and simulations to ascertain the probability of target attainment (PTA).ResultsTeicoplanin was well characterized by a one-compartment PK model with first-order elimination. The presence of CRRT was associated with a lower volume of distribution (V), and gender was associated with a higher V. When MIC was set at 1 mg/L, a loading dose of 800 mg (q12h) followed by a maintenance dose of 600 mg (q24h) was necessary for male sepsis patients without CRRT, and a loading dose of 800 mg (q12h) followed by a maintenance dose of 800 mg (q24h) for male sepsis patients receiving CRRT. Female patients with sepsis required a loading dose of 1,000 mg q12h followed by a maintenance dose of 1,000 mg q24h.ConclusionTeicoplanin therapy in sepsis patients undergoing CRRT necessitates individualized dosing. A PK model-based teicoplanin dosing regimen for sepsis patients with CRRT was proposed, whereas prospective clinical study is required to validate. |
| format | Article |
| id | doaj-art-49b3d2518e564eeeb45701525e9b558d |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-49b3d2518e564eeeb45701525e9b558d2025-08-20T03:30:01ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-07-011610.3389/fphar.2025.16219591621959Population pharmacokinetics of teicoplanin and dosage optimization in sepsis patients based on continuous renal replacement therapyQian Sun0Jiang Jian1Xueqiang Zhou2Zhu Hong3Suwen Yang4Yanping Zheng5Siyi Wang6Maojun Zhao7Department of Intensive Care Unit, Beijing Jishuitan Hospital Guizhou Hospital, Guiyang, Guizhou, ChinaDepartment of Intensive Care Unit, Beijing Jishuitan Hospital Guizhou Hospital, Guiyang, Guizhou, ChinaDepartment of Intensive Care Unit, Beijing Jishuitan Hospital Guizhou Hospital, Guiyang, Guizhou, ChinaDepartment of Pathogenic microorganism, Bijie Medical College, Bijie, Guizhou, ChinaDepartment of Clinical Laboratory Medicine, Kaiyang County People’s Hospital, Guiyang, Guizhou, ChinaDepartment of Intensive Care Unit, Beijing Jishuitan Hospital Guizhou Hospital, Guiyang, Guizhou, ChinaDepartment of Pharmacy, Huadu District People’s Hospital of Guangzhou, Guangzhou, ChinaDepartment of Intensive Care Unit, Beijing Jishuitan Hospital Guizhou Hospital, Guiyang, Guizhou, ChinaPurposeIt is well known that pharmacokinetics (PK) of drugs is significantly altered in sepsis patients receiving continuous renal replacement therapy (CRRT). However, clinical studies investigating the PK of drugs administered during CRRT are limited, and appropriate dosing regimens have not yet to be definitively established. The study aimed to develop a population PK model for teicoplanin, explore significant covariates regarding to teicoplanin PK, and propose optimal dosage strategies for sepsis patients.MethodsEighty-six sepsis patients were included and plasma samples from all patients were analyzed. PK analysis was conducted on samples from 86 sepsis patients, followed by population PK analysis and simulations to ascertain the probability of target attainment (PTA).ResultsTeicoplanin was well characterized by a one-compartment PK model with first-order elimination. The presence of CRRT was associated with a lower volume of distribution (V), and gender was associated with a higher V. When MIC was set at 1 mg/L, a loading dose of 800 mg (q12h) followed by a maintenance dose of 600 mg (q24h) was necessary for male sepsis patients without CRRT, and a loading dose of 800 mg (q12h) followed by a maintenance dose of 800 mg (q24h) for male sepsis patients receiving CRRT. Female patients with sepsis required a loading dose of 1,000 mg q12h followed by a maintenance dose of 1,000 mg q24h.ConclusionTeicoplanin therapy in sepsis patients undergoing CRRT necessitates individualized dosing. A PK model-based teicoplanin dosing regimen for sepsis patients with CRRT was proposed, whereas prospective clinical study is required to validate.https://www.frontiersin.org/articles/10.3389/fphar.2025.1621959/fullteicoplaninpharmacokineticsdosage optimizationsepsiscontinuous renal replacement therapy |
| spellingShingle | Qian Sun Jiang Jian Xueqiang Zhou Zhu Hong Suwen Yang Yanping Zheng Siyi Wang Maojun Zhao Population pharmacokinetics of teicoplanin and dosage optimization in sepsis patients based on continuous renal replacement therapy Frontiers in Pharmacology teicoplanin pharmacokinetics dosage optimization sepsis continuous renal replacement therapy |
| title | Population pharmacokinetics of teicoplanin and dosage optimization in sepsis patients based on continuous renal replacement therapy |
| title_full | Population pharmacokinetics of teicoplanin and dosage optimization in sepsis patients based on continuous renal replacement therapy |
| title_fullStr | Population pharmacokinetics of teicoplanin and dosage optimization in sepsis patients based on continuous renal replacement therapy |
| title_full_unstemmed | Population pharmacokinetics of teicoplanin and dosage optimization in sepsis patients based on continuous renal replacement therapy |
| title_short | Population pharmacokinetics of teicoplanin and dosage optimization in sepsis patients based on continuous renal replacement therapy |
| title_sort | population pharmacokinetics of teicoplanin and dosage optimization in sepsis patients based on continuous renal replacement therapy |
| topic | teicoplanin pharmacokinetics dosage optimization sepsis continuous renal replacement therapy |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1621959/full |
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