Short and Mid-term Outcomes of Percutaneous Perimembranous Ventricular Septal Defect Closure Using Amplatzer Duct Occluders Type II in Children and Adolescents
Background: Percutaneous closure of perimembranous ventricular septal defects (pmVSD) with Amplatzer duct occluder type II (ADO II) is a novel method. The present study aimed to evaluate the short and mid-term outcomes of this method in children and adolescents. Methods: This retrospective study was...
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Shiraz University of Medical Sciences
2025-06-01
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| Series: | Iranian Journal of Medical Sciences |
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| Online Access: | https://ijms.sums.ac.ir/article_50909_42f41dcc33c42eee84baead6d5778eb6.pdf |
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| author | Hamid Amoozgar Hamid Arabi Mohammadreza Edraki Amir Naghshzan Nima Mehdizadegan Hamid Mohammadi Mohammadjavad Nobakhti Kambiz Keshavarz |
| author_facet | Hamid Amoozgar Hamid Arabi Mohammadreza Edraki Amir Naghshzan Nima Mehdizadegan Hamid Mohammadi Mohammadjavad Nobakhti Kambiz Keshavarz |
| author_sort | Hamid Amoozgar |
| collection | DOAJ |
| description | Background: Percutaneous closure of perimembranous ventricular septal defects (pmVSD) with Amplatzer duct occluder type II (ADO II) is a novel method. The present study aimed to evaluate the short and mid-term outcomes of this method in children and adolescents. Methods: This retrospective study was conducted at Shiraz University of Medical Sciences from July 2019 to September 2023. It evaluated the outcomes of pmVSD closure using the ADO II. The effects on tricuspid regurgitation (TR), mitral regurgitation (MR), and aortic regurgitation (AR) were assessed, along with the presence of residual shunts and conduction disturbances. Data were analyzed using SPSS software (version 24.0). Fisher’s exact test and the Chi square test were employed for statistical analysis. P<0.05 was considered statistically significant.Results: This study included 102 patients. 31 patients had a short-term follow-up with a median of 79 (71.02, 97.01) days, and 71 patients had a mid-term follow-up with a median of 900 (384.25, 1044.75) days. The severity of TR, MR, and AR dropped to lower levels in most patients during follow-ups (P=0.003, P=0.030, and P=0.033, respectively). There was no significant difference in the valvar regurgitation changes between patients weighing more or less than 10 Kg or between those with short and mid-term follow-ups (P>0.05). There were no hemolysis, clot, embolization, death, or third-degree atrioventricular blocks. However, 2 (2%) patients developed a small residual shunt.Conclusion: Overall, ADO II appeared to be a safe transcatheter occlusion device for patients with pmVSD, and this method could reduce the severity of TR, MR, and AR with few complications. |
| format | Article |
| id | doaj-art-49b080e7cf424ed7ae13c75c5a8e53ec |
| institution | Kabale University |
| issn | 0253-0716 1735-3688 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Shiraz University of Medical Sciences |
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| series | Iranian Journal of Medical Sciences |
| spelling | doaj-art-49b080e7cf424ed7ae13c75c5a8e53ec2025-08-20T03:28:29ZengShiraz University of Medical SciencesIranian Journal of Medical Sciences0253-07161735-36882025-06-0150639340310.30476/ijms.2024.102819.359550909Short and Mid-term Outcomes of Percutaneous Perimembranous Ventricular Septal Defect Closure Using Amplatzer Duct Occluders Type II in Children and AdolescentsHamid Amoozgar0Hamid Arabi1Mohammadreza Edraki2Amir Naghshzan3Nima Mehdizadegan4Hamid Mohammadi5Mohammadjavad Nobakhti6Kambiz Keshavarz7Department of Pediatrics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Pediatrics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Pediatrics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Pediatrics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Pediatrics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Pediatrics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Cardiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Pediatrics, School of Medicine, Yasuj University of Medical Sciences, Yasuj, IranBackground: Percutaneous closure of perimembranous ventricular septal defects (pmVSD) with Amplatzer duct occluder type II (ADO II) is a novel method. The present study aimed to evaluate the short and mid-term outcomes of this method in children and adolescents. Methods: This retrospective study was conducted at Shiraz University of Medical Sciences from July 2019 to September 2023. It evaluated the outcomes of pmVSD closure using the ADO II. The effects on tricuspid regurgitation (TR), mitral regurgitation (MR), and aortic regurgitation (AR) were assessed, along with the presence of residual shunts and conduction disturbances. Data were analyzed using SPSS software (version 24.0). Fisher’s exact test and the Chi square test were employed for statistical analysis. P<0.05 was considered statistically significant.Results: This study included 102 patients. 31 patients had a short-term follow-up with a median of 79 (71.02, 97.01) days, and 71 patients had a mid-term follow-up with a median of 900 (384.25, 1044.75) days. The severity of TR, MR, and AR dropped to lower levels in most patients during follow-ups (P=0.003, P=0.030, and P=0.033, respectively). There was no significant difference in the valvar regurgitation changes between patients weighing more or less than 10 Kg or between those with short and mid-term follow-ups (P>0.05). There were no hemolysis, clot, embolization, death, or third-degree atrioventricular blocks. However, 2 (2%) patients developed a small residual shunt.Conclusion: Overall, ADO II appeared to be a safe transcatheter occlusion device for patients with pmVSD, and this method could reduce the severity of TR, MR, and AR with few complications.https://ijms.sums.ac.ir/article_50909_42f41dcc33c42eee84baead6d5778eb6.pdfheart septal defectsseptal occluder devicecardiac catheterization |
| spellingShingle | Hamid Amoozgar Hamid Arabi Mohammadreza Edraki Amir Naghshzan Nima Mehdizadegan Hamid Mohammadi Mohammadjavad Nobakhti Kambiz Keshavarz Short and Mid-term Outcomes of Percutaneous Perimembranous Ventricular Septal Defect Closure Using Amplatzer Duct Occluders Type II in Children and Adolescents Iranian Journal of Medical Sciences heart septal defects septal occluder device cardiac catheterization |
| title | Short and Mid-term Outcomes of Percutaneous Perimembranous Ventricular Septal Defect Closure Using Amplatzer Duct Occluders Type II in Children and Adolescents |
| title_full | Short and Mid-term Outcomes of Percutaneous Perimembranous Ventricular Septal Defect Closure Using Amplatzer Duct Occluders Type II in Children and Adolescents |
| title_fullStr | Short and Mid-term Outcomes of Percutaneous Perimembranous Ventricular Septal Defect Closure Using Amplatzer Duct Occluders Type II in Children and Adolescents |
| title_full_unstemmed | Short and Mid-term Outcomes of Percutaneous Perimembranous Ventricular Septal Defect Closure Using Amplatzer Duct Occluders Type II in Children and Adolescents |
| title_short | Short and Mid-term Outcomes of Percutaneous Perimembranous Ventricular Septal Defect Closure Using Amplatzer Duct Occluders Type II in Children and Adolescents |
| title_sort | short and mid term outcomes of percutaneous perimembranous ventricular septal defect closure using amplatzer duct occluders type ii in children and adolescents |
| topic | heart septal defects septal occluder device cardiac catheterization |
| url | https://ijms.sums.ac.ir/article_50909_42f41dcc33c42eee84baead6d5778eb6.pdf |
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