Nanotechnology-Based Strategies for Safe and Effective Immunotherapy
Cancer immunotherapy using immune checkpoint blockades has emerged as a promising therapeutic approach. However, immunotherapy faces challenges such as low response rates in solid tumors, necessitating strategies to remodel the immune-suppressive tumor microenvironment (TME) into an immune-activated...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/29/24/5855 |
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| _version_ | 1850037113045647360 |
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| author | Seeun Hong Juwon Park Yoojeong Oh Hanhee Cho Kwangmeyung Kim |
| author_facet | Seeun Hong Juwon Park Yoojeong Oh Hanhee Cho Kwangmeyung Kim |
| author_sort | Seeun Hong |
| collection | DOAJ |
| description | Cancer immunotherapy using immune checkpoint blockades has emerged as a promising therapeutic approach. However, immunotherapy faces challenges such as low response rates in solid tumors, necessitating strategies to remodel the immune-suppressive tumor microenvironment (TME) into an immune-activated state. One of the primary approaches to achieve this transformation is through the induction of immunogenic cell death (ICD). Herein, we discussed strategies to maximize ICD induction using nanoparticles. In particular, this review highlighted various studies integrating chemotherapy, radiation therapy (RT), photodynamic therapy (PDT), and photothermal therapy (PTT) with nanoparticle-based immunotherapy. The research covered in this review aims to provide valuable insights for future studies on nanoparticle-assisted immunotherapy. |
| format | Article |
| id | doaj-art-49abbb08f3bf40619a73df9b2ae9ea52 |
| institution | DOAJ |
| issn | 1420-3049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-49abbb08f3bf40619a73df9b2ae9ea522025-08-20T02:56:57ZengMDPI AGMolecules1420-30492024-12-012924585510.3390/molecules29245855Nanotechnology-Based Strategies for Safe and Effective ImmunotherapySeeun Hong0Juwon Park1Yoojeong Oh2Hanhee Cho3Kwangmeyung Kim4Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul 03760, Republic of KoreaGraduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul 03760, Republic of KoreaGraduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul 03760, Republic of KoreaGraduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul 03760, Republic of KoreaGraduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul 03760, Republic of KoreaCancer immunotherapy using immune checkpoint blockades has emerged as a promising therapeutic approach. However, immunotherapy faces challenges such as low response rates in solid tumors, necessitating strategies to remodel the immune-suppressive tumor microenvironment (TME) into an immune-activated state. One of the primary approaches to achieve this transformation is through the induction of immunogenic cell death (ICD). Herein, we discussed strategies to maximize ICD induction using nanoparticles. In particular, this review highlighted various studies integrating chemotherapy, radiation therapy (RT), photodynamic therapy (PDT), and photothermal therapy (PTT) with nanoparticle-based immunotherapy. The research covered in this review aims to provide valuable insights for future studies on nanoparticle-assisted immunotherapy.https://www.mdpi.com/1420-3049/29/24/5855drug deliverycancer treatmentnanoparticleimmunotherapychemotherapyphotodynamic therapy |
| spellingShingle | Seeun Hong Juwon Park Yoojeong Oh Hanhee Cho Kwangmeyung Kim Nanotechnology-Based Strategies for Safe and Effective Immunotherapy Molecules drug delivery cancer treatment nanoparticle immunotherapy chemotherapy photodynamic therapy |
| title | Nanotechnology-Based Strategies for Safe and Effective Immunotherapy |
| title_full | Nanotechnology-Based Strategies for Safe and Effective Immunotherapy |
| title_fullStr | Nanotechnology-Based Strategies for Safe and Effective Immunotherapy |
| title_full_unstemmed | Nanotechnology-Based Strategies for Safe and Effective Immunotherapy |
| title_short | Nanotechnology-Based Strategies for Safe and Effective Immunotherapy |
| title_sort | nanotechnology based strategies for safe and effective immunotherapy |
| topic | drug delivery cancer treatment nanoparticle immunotherapy chemotherapy photodynamic therapy |
| url | https://www.mdpi.com/1420-3049/29/24/5855 |
| work_keys_str_mv | AT seeunhong nanotechnologybasedstrategiesforsafeandeffectiveimmunotherapy AT juwonpark nanotechnologybasedstrategiesforsafeandeffectiveimmunotherapy AT yoojeongoh nanotechnologybasedstrategiesforsafeandeffectiveimmunotherapy AT hanheecho nanotechnologybasedstrategiesforsafeandeffectiveimmunotherapy AT kwangmeyungkim nanotechnologybasedstrategiesforsafeandeffectiveimmunotherapy |