Curcumin and Metformin Infinite Coordination Polymer Nanoparticles for Combined Therapy of Diabetic Mice via Intraperitoneal Injections
Metformin (Met) is one of the most commonly prescribed first-line drugs for diabetes treatment. However, it has several issues, including low bioavailability, therapeutic platform, and side effects at high doses. In order to improve the therapeutic efficiency of Met, this study proposes a strategy o...
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MDPI AG
2024-12-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/15/12/388 |
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| author | Siwei Sun Xinyi Hou Ke Li Chenqi Huang Yu Rong Jiao Bi Xueping Li Daocheng Wu |
| author_facet | Siwei Sun Xinyi Hou Ke Li Chenqi Huang Yu Rong Jiao Bi Xueping Li Daocheng Wu |
| author_sort | Siwei Sun |
| collection | DOAJ |
| description | Metformin (Met) is one of the most commonly prescribed first-line drugs for diabetes treatment. However, it has several issues, including low bioavailability, therapeutic platform, and side effects at high doses. In order to improve the therapeutic efficiency of Met, this study proposes a strategy of using Met and curcumin (Cur) to prepare Cur-Zn(II)-Met infinite coordination polymer nanoparticles (CM ICP NPs), and combining this with intraperitoneal injections, for the treatment of diabetic mice. Fourier transform infrared (FTIR) spectroscopy, X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), nanoparticle analysis, cytotoxicity experiments, and mice experiments were used to investigate structure, properties, and application effects. The results showed that CM ICP NPs exhibit a high drug encapsulation rate (100%), good stability, and an absence of in vivo and in vitro toxicity. The blood glucose level of diabetic mice after treatment was reduced to 6.7 ± 0.65 mmol/L at the seventh week. In terms of therapeutic mechanism, it appears that Met and Cur can synergistically regulate blood glucose in mice from multiple paths. This study provides a promising method for the treatment of diabetes using Met and other drugs. |
| format | Article |
| id | doaj-art-49a927d9c7d04d0f8e5a472c615a3cd9 |
| institution | Kabale University |
| issn | 2079-4983 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
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| series | Journal of Functional Biomaterials |
| spelling | doaj-art-49a927d9c7d04d0f8e5a472c615a3cd92024-12-27T14:32:07ZengMDPI AGJournal of Functional Biomaterials2079-49832024-12-01151238810.3390/jfb15120388Curcumin and Metformin Infinite Coordination Polymer Nanoparticles for Combined Therapy of Diabetic Mice via Intraperitoneal InjectionsSiwei Sun0Xinyi Hou1Ke Li2Chenqi Huang3Yu Rong4Jiao Bi5Xueping Li6Daocheng Wu7Institute of Basic and Translational Medicine, Xi’an Medical University, Xi’an 710021, ChinaXi’an Key Laboratory for Prevention and Treatment of Common Aging Diseases, Translational and Research Centre for Prevention and Therapy of Chronic Disease, Xi’an Medical University, Xi’an 710021, ChinaInstitute of Basic and Translational Medicine, Xi’an Medical University, Xi’an 710021, ChinaKey Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, ChinaInstitute of Basic and Translational Medicine, Xi’an Medical University, Xi’an 710021, ChinaInstitute of Basic and Translational Medicine, Xi’an Medical University, Xi’an 710021, ChinaXi’an Key Laboratory for Prevention and Treatment of Common Aging Diseases, Translational and Research Centre for Prevention and Therapy of Chronic Disease, Xi’an Medical University, Xi’an 710021, ChinaKey Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, ChinaMetformin (Met) is one of the most commonly prescribed first-line drugs for diabetes treatment. However, it has several issues, including low bioavailability, therapeutic platform, and side effects at high doses. In order to improve the therapeutic efficiency of Met, this study proposes a strategy of using Met and curcumin (Cur) to prepare Cur-Zn(II)-Met infinite coordination polymer nanoparticles (CM ICP NPs), and combining this with intraperitoneal injections, for the treatment of diabetic mice. Fourier transform infrared (FTIR) spectroscopy, X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), nanoparticle analysis, cytotoxicity experiments, and mice experiments were used to investigate structure, properties, and application effects. The results showed that CM ICP NPs exhibit a high drug encapsulation rate (100%), good stability, and an absence of in vivo and in vitro toxicity. The blood glucose level of diabetic mice after treatment was reduced to 6.7 ± 0.65 mmol/L at the seventh week. In terms of therapeutic mechanism, it appears that Met and Cur can synergistically regulate blood glucose in mice from multiple paths. This study provides a promising method for the treatment of diabetes using Met and other drugs.https://www.mdpi.com/2079-4983/15/12/388infinite coordination polymernanoparticlesmetformincurcumindiabetescombination therapy |
| spellingShingle | Siwei Sun Xinyi Hou Ke Li Chenqi Huang Yu Rong Jiao Bi Xueping Li Daocheng Wu Curcumin and Metformin Infinite Coordination Polymer Nanoparticles for Combined Therapy of Diabetic Mice via Intraperitoneal Injections Journal of Functional Biomaterials infinite coordination polymer nanoparticles metformin curcumin diabetes combination therapy |
| title | Curcumin and Metformin Infinite Coordination Polymer Nanoparticles for Combined Therapy of Diabetic Mice via Intraperitoneal Injections |
| title_full | Curcumin and Metformin Infinite Coordination Polymer Nanoparticles for Combined Therapy of Diabetic Mice via Intraperitoneal Injections |
| title_fullStr | Curcumin and Metformin Infinite Coordination Polymer Nanoparticles for Combined Therapy of Diabetic Mice via Intraperitoneal Injections |
| title_full_unstemmed | Curcumin and Metformin Infinite Coordination Polymer Nanoparticles for Combined Therapy of Diabetic Mice via Intraperitoneal Injections |
| title_short | Curcumin and Metformin Infinite Coordination Polymer Nanoparticles for Combined Therapy of Diabetic Mice via Intraperitoneal Injections |
| title_sort | curcumin and metformin infinite coordination polymer nanoparticles for combined therapy of diabetic mice via intraperitoneal injections |
| topic | infinite coordination polymer nanoparticles metformin curcumin diabetes combination therapy |
| url | https://www.mdpi.com/2079-4983/15/12/388 |
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