Synthesis of Mannich N-bases based on benzimidazole derivatives using SiO2OAlCl2 catalyst and their potential as antioxidant, antibacterial, and anticancer agents
This research aimed to synthesis of N-base compounds based on benzimidazole derivatives and their potential as antibacterials, antioxidants, and anticancer. The synthesis was conducted in two stages, namely the intermediate (benzimidazole derivatives) and the final product (N-mannich base), using fi...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | South African Journal of Chemical Engineering |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1026918524001318 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832595391742214144 |
|---|---|
| author | Antonius Herry Cahyana Ikrimah Desta Laely Amaliyah Aida Nadia Hilna Diana Sahaya Dicky Annas Bayu Ardiansah Mohammad Jihad Madiabu Inda Mapiliandari Kang Hyun Park |
| author_facet | Antonius Herry Cahyana Ikrimah Desta Laely Amaliyah Aida Nadia Hilna Diana Sahaya Dicky Annas Bayu Ardiansah Mohammad Jihad Madiabu Inda Mapiliandari Kang Hyun Park |
| author_sort | Antonius Herry Cahyana |
| collection | DOAJ |
| description | This research aimed to synthesis of N-base compounds based on benzimidazole derivatives and their potential as antibacterials, antioxidants, and anticancer. The synthesis was conducted in two stages, namely the intermediate (benzimidazole derivatives) and the final product (N-mannich base), using five variations of organic acids and SiO2OAlCl2 as catalyst. The results showed that the catalyst was successfully synthesized and characterized by The Fourier transform infrared (FTIR), X-ray diffraction (XRD), and Scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDS). The purity of the synthesized compounds was monitored by Thin layer chromatography (TLC), melting point test, Ultraviolet-visible (UV–Vis), and Liquid chromatography-Mass spectrometry (LC-MS). The five intermediate compounds and five mannich base products yield 77 %-89 % and 65 %-85 %, respectively. The final products were applied through antibacterial testing against Staphylococcus aureus (Gram-positive bacteria) and Escherichia coli (Gram-negative bacteria) by disc diffusion. Mannich base compounds have potential antibacterial agents, but only 4A and 4E gave the best inhibition zone diameter. Meanwhile, the antioxidant testing result using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method showed the best activity in the mannich base compound 4E. The anticancer test result showed that the five mannich base compounds had potential as anticancer agents. |
| format | Article |
| id | doaj-art-49a3f8ed9ad2457a915f5a01d2437b6b |
| institution | Kabale University |
| issn | 1026-9185 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | South African Journal of Chemical Engineering |
| spelling | doaj-art-49a3f8ed9ad2457a915f5a01d2437b6b2025-01-19T06:24:17ZengElsevierSouth African Journal of Chemical Engineering1026-91852025-01-015195111Synthesis of Mannich N-bases based on benzimidazole derivatives using SiO2OAlCl2 catalyst and their potential as antioxidant, antibacterial, and anticancer agentsAntonius Herry Cahyana0Ikrimah Desta1Laely Amaliyah2Aida Nadia3Hilna Diana Sahaya4Dicky Annas5Bayu Ardiansah6Mohammad Jihad Madiabu7Inda Mapiliandari8Kang Hyun Park9Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok 16242, Indonesia; Corresponding authors.Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok 16242, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok 16242, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok 16242, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok 16242, IndonesiaResearch Center for Chemistry, National Research and Innovation Agency (BRIN), B.J. Habibie Science and Technology Area, South Tangerang 15314, Indonesia; Corresponding authors.Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok 16242, IndonesiaDepartment of Analytical Chemistry, Politeknik AKA Bogor, Bogor 16154, IndonesiaDepartment of Analytical Chemistry, Politeknik AKA Bogor, Bogor 16154, IndonesiaDepartment of Chemistry, Pusan National University, Busan, 46241, Republic of KoreaThis research aimed to synthesis of N-base compounds based on benzimidazole derivatives and their potential as antibacterials, antioxidants, and anticancer. The synthesis was conducted in two stages, namely the intermediate (benzimidazole derivatives) and the final product (N-mannich base), using five variations of organic acids and SiO2OAlCl2 as catalyst. The results showed that the catalyst was successfully synthesized and characterized by The Fourier transform infrared (FTIR), X-ray diffraction (XRD), and Scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDS). The purity of the synthesized compounds was monitored by Thin layer chromatography (TLC), melting point test, Ultraviolet-visible (UV–Vis), and Liquid chromatography-Mass spectrometry (LC-MS). The five intermediate compounds and five mannich base products yield 77 %-89 % and 65 %-85 %, respectively. The final products were applied through antibacterial testing against Staphylococcus aureus (Gram-positive bacteria) and Escherichia coli (Gram-negative bacteria) by disc diffusion. Mannich base compounds have potential antibacterial agents, but only 4A and 4E gave the best inhibition zone diameter. Meanwhile, the antioxidant testing result using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method showed the best activity in the mannich base compound 4E. The anticancer test result showed that the five mannich base compounds had potential as anticancer agents.http://www.sciencedirect.com/science/article/pii/S1026918524001318BenzimidazoleN-mannich baseSiO2-OAlCl2AntibacterialAntioxidantAnticancer |
| spellingShingle | Antonius Herry Cahyana Ikrimah Desta Laely Amaliyah Aida Nadia Hilna Diana Sahaya Dicky Annas Bayu Ardiansah Mohammad Jihad Madiabu Inda Mapiliandari Kang Hyun Park Synthesis of Mannich N-bases based on benzimidazole derivatives using SiO2OAlCl2 catalyst and their potential as antioxidant, antibacterial, and anticancer agents South African Journal of Chemical Engineering Benzimidazole N-mannich base SiO2-OAlCl2 Antibacterial Antioxidant Anticancer |
| title | Synthesis of Mannich N-bases based on benzimidazole derivatives using SiO2OAlCl2 catalyst and their potential as antioxidant, antibacterial, and anticancer agents |
| title_full | Synthesis of Mannich N-bases based on benzimidazole derivatives using SiO2OAlCl2 catalyst and their potential as antioxidant, antibacterial, and anticancer agents |
| title_fullStr | Synthesis of Mannich N-bases based on benzimidazole derivatives using SiO2OAlCl2 catalyst and their potential as antioxidant, antibacterial, and anticancer agents |
| title_full_unstemmed | Synthesis of Mannich N-bases based on benzimidazole derivatives using SiO2OAlCl2 catalyst and their potential as antioxidant, antibacterial, and anticancer agents |
| title_short | Synthesis of Mannich N-bases based on benzimidazole derivatives using SiO2OAlCl2 catalyst and their potential as antioxidant, antibacterial, and anticancer agents |
| title_sort | synthesis of mannich n bases based on benzimidazole derivatives using sio2oalcl2 catalyst and their potential as antioxidant antibacterial and anticancer agents |
| topic | Benzimidazole N-mannich base SiO2-OAlCl2 Antibacterial Antioxidant Anticancer |
| url | http://www.sciencedirect.com/science/article/pii/S1026918524001318 |
| work_keys_str_mv | AT antoniusherrycahyana synthesisofmannichnbasesbasedonbenzimidazolederivativesusingsio2oalcl2catalystandtheirpotentialasantioxidantantibacterialandanticanceragents AT ikrimahdesta synthesisofmannichnbasesbasedonbenzimidazolederivativesusingsio2oalcl2catalystandtheirpotentialasantioxidantantibacterialandanticanceragents AT laelyamaliyah synthesisofmannichnbasesbasedonbenzimidazolederivativesusingsio2oalcl2catalystandtheirpotentialasantioxidantantibacterialandanticanceragents AT aidanadia synthesisofmannichnbasesbasedonbenzimidazolederivativesusingsio2oalcl2catalystandtheirpotentialasantioxidantantibacterialandanticanceragents AT hilnadianasahaya synthesisofmannichnbasesbasedonbenzimidazolederivativesusingsio2oalcl2catalystandtheirpotentialasantioxidantantibacterialandanticanceragents AT dickyannas synthesisofmannichnbasesbasedonbenzimidazolederivativesusingsio2oalcl2catalystandtheirpotentialasantioxidantantibacterialandanticanceragents AT bayuardiansah synthesisofmannichnbasesbasedonbenzimidazolederivativesusingsio2oalcl2catalystandtheirpotentialasantioxidantantibacterialandanticanceragents AT mohammadjihadmadiabu synthesisofmannichnbasesbasedonbenzimidazolederivativesusingsio2oalcl2catalystandtheirpotentialasantioxidantantibacterialandanticanceragents AT indamapiliandari synthesisofmannichnbasesbasedonbenzimidazolederivativesusingsio2oalcl2catalystandtheirpotentialasantioxidantantibacterialandanticanceragents AT kanghyunpark synthesisofmannichnbasesbasedonbenzimidazolederivativesusingsio2oalcl2catalystandtheirpotentialasantioxidantantibacterialandanticanceragents |