Stem Cell Therapy in Acute Myocardial Infarction: A Pot of Gold or Pandora's Box
Stem cell therapy for conditions characterized by myocyte loss in myocardial infarction and heart failure is intuitively appealing. Stem cells from various sources, including heart itself in preclinical and animal studies, have shown the potential to improve the function of ventricular muscle after...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.4061/2011/536758 |
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| _version_ | 1850181466679410688 |
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| author | V. K. Shah K. K. Shalia |
| author_facet | V. K. Shah K. K. Shalia |
| author_sort | V. K. Shah |
| collection | DOAJ |
| description | Stem cell therapy for conditions characterized by myocyte loss in myocardial infarction and heart failure is intuitively appealing. Stem cells from various sources, including heart itself in preclinical and animal studies, have shown the potential to improve the function of ventricular muscle after ischaemic injury. The clinical experience from worldwide studies have indicated the safety profile but with modest benefits. The predominant mechanisms of transplanted cells for improving cardiac function have pointed towards paracrine effects rather than transdifferentiation into cardiomyocytes. Thus, further investigations should be encouraged towards bench side and bedside to resolve various issues for ensuring the correct type and dosing of cells, time, and method of delivery and identify correct mechanism of functional improvement. An interdisciplinary effort at the scientific, clinical, and the government front will bring successful realization of this therapy for healing the heart and may convert what seems now a Pandora's Box into a Pot of Gold. |
| format | Article |
| id | doaj-art-49a39fa22976495d8bd9c60de545b2a9 |
| institution | OA Journals |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-49a39fa22976495d8bd9c60de545b2a92025-08-20T02:17:53ZengWileyStem Cells International1687-966X1687-96782011-01-01201110.4061/2011/536758536758Stem Cell Therapy in Acute Myocardial Infarction: A Pot of Gold or Pandora's BoxV. K. Shah0K. K. Shalia1Interventional Cardiologist, Sir H.N. Hospital and Research Centre, Raja Rammohan Roy Road, Mumbai 400 004, IndiaSir H.N. Medical Research Society, Sir H.N. Hospital and Research Centre, Raja Rammohan Roy Road, Mumbai 400 004, IndiaStem cell therapy for conditions characterized by myocyte loss in myocardial infarction and heart failure is intuitively appealing. Stem cells from various sources, including heart itself in preclinical and animal studies, have shown the potential to improve the function of ventricular muscle after ischaemic injury. The clinical experience from worldwide studies have indicated the safety profile but with modest benefits. The predominant mechanisms of transplanted cells for improving cardiac function have pointed towards paracrine effects rather than transdifferentiation into cardiomyocytes. Thus, further investigations should be encouraged towards bench side and bedside to resolve various issues for ensuring the correct type and dosing of cells, time, and method of delivery and identify correct mechanism of functional improvement. An interdisciplinary effort at the scientific, clinical, and the government front will bring successful realization of this therapy for healing the heart and may convert what seems now a Pandora's Box into a Pot of Gold.http://dx.doi.org/10.4061/2011/536758 |
| spellingShingle | V. K. Shah K. K. Shalia Stem Cell Therapy in Acute Myocardial Infarction: A Pot of Gold or Pandora's Box Stem Cells International |
| title | Stem Cell Therapy in Acute Myocardial Infarction: A Pot of Gold or Pandora's Box |
| title_full | Stem Cell Therapy in Acute Myocardial Infarction: A Pot of Gold or Pandora's Box |
| title_fullStr | Stem Cell Therapy in Acute Myocardial Infarction: A Pot of Gold or Pandora's Box |
| title_full_unstemmed | Stem Cell Therapy in Acute Myocardial Infarction: A Pot of Gold or Pandora's Box |
| title_short | Stem Cell Therapy in Acute Myocardial Infarction: A Pot of Gold or Pandora's Box |
| title_sort | stem cell therapy in acute myocardial infarction a pot of gold or pandora s box |
| url | http://dx.doi.org/10.4061/2011/536758 |
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