Exploring the role of protein palmitoylation in cancer progression and therapy: a comprehensive bibliometric study (2004–2024)
Abstract Objective This study aims to qualitatively and quantitatively assess the research landscape of palmitoylation in oncology using bibliometric analysis, thereby providing insights into research hotspots and emerging trends. Methods The data were sourced from the Web of Science Core Collection...
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| Format: | Article |
| Language: | English |
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Springer
2025-07-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-03059-0 |
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| author | Yu Chen Yuxuan Dai Xing Wang Jian Liu |
| author_facet | Yu Chen Yuxuan Dai Xing Wang Jian Liu |
| author_sort | Yu Chen |
| collection | DOAJ |
| description | Abstract Objective This study aims to qualitatively and quantitatively assess the research landscape of palmitoylation in oncology using bibliometric analysis, thereby providing insights into research hotspots and emerging trends. Methods The data were sourced from the Web of Science Core Collection, retrieved using predefined search terms, and comprise review articles and original research papers published in English from 2004 to 2024. Bibliometric analysis and data visualization were performed using VOSviewer, CiteSpace, and Microsoft Excel. Results The United States and China are the leading contributors to research in this field, with Shanghai Jiao Tong University being the most prolific institution in terms of publication output. Current research hotspots in protein palmitoylation related to oncology primarily encompass the enzymatic mechanisms and dynamic regulation of palmitoylation, palmitoylation-mediated lipid metabolic reprogramming and tumorigenesis, palmitoylation-mediated tumor signaling pathways, and targeted cancer therapy strategies based on palmitoylation modification. Current research trends primarily focus on the modulation of critical enzymes and signaling pathways, which influence tumor biology and prognosis. Additionally, emphasis is placed on metabolic reprogramming mediated by protein palmitoylation within the tumor microenvironment, especially regarding its role in tumor responsiveness to chemotherapy and immunotherapy. Conclusion This study provides a comprehensive overview of recent advancements in research regarding protein palmitoylation modifications within oncology. |
| format | Article |
| id | doaj-art-499b2b972ffb4418ab076b8ebaac3e8a |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-499b2b972ffb4418ab076b8ebaac3e8a2025-08-20T03:45:31ZengSpringerDiscover Oncology2730-60112025-07-0116111710.1007/s12672-025-03059-0Exploring the role of protein palmitoylation in cancer progression and therapy: a comprehensive bibliometric study (2004–2024)Yu Chen0Yuxuan Dai1Xing Wang2Jian Liu3Department of Surgical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Plastic Surgery, Beilun Branch of the First Affiliated Hospital, College of Medicine, Zhejiang UniversityDepartment of Head Neck Surgery, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of SciencesDepartment of Surgical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang UniversityAbstract Objective This study aims to qualitatively and quantitatively assess the research landscape of palmitoylation in oncology using bibliometric analysis, thereby providing insights into research hotspots and emerging trends. Methods The data were sourced from the Web of Science Core Collection, retrieved using predefined search terms, and comprise review articles and original research papers published in English from 2004 to 2024. Bibliometric analysis and data visualization were performed using VOSviewer, CiteSpace, and Microsoft Excel. Results The United States and China are the leading contributors to research in this field, with Shanghai Jiao Tong University being the most prolific institution in terms of publication output. Current research hotspots in protein palmitoylation related to oncology primarily encompass the enzymatic mechanisms and dynamic regulation of palmitoylation, palmitoylation-mediated lipid metabolic reprogramming and tumorigenesis, palmitoylation-mediated tumor signaling pathways, and targeted cancer therapy strategies based on palmitoylation modification. Current research trends primarily focus on the modulation of critical enzymes and signaling pathways, which influence tumor biology and prognosis. Additionally, emphasis is placed on metabolic reprogramming mediated by protein palmitoylation within the tumor microenvironment, especially regarding its role in tumor responsiveness to chemotherapy and immunotherapy. Conclusion This study provides a comprehensive overview of recent advancements in research regarding protein palmitoylation modifications within oncology.https://doi.org/10.1007/s12672-025-03059-0PalmitoylationCancerMetabolic reprogrammingImmunotherapyBibliometrics |
| spellingShingle | Yu Chen Yuxuan Dai Xing Wang Jian Liu Exploring the role of protein palmitoylation in cancer progression and therapy: a comprehensive bibliometric study (2004–2024) Discover Oncology Palmitoylation Cancer Metabolic reprogramming Immunotherapy Bibliometrics |
| title | Exploring the role of protein palmitoylation in cancer progression and therapy: a comprehensive bibliometric study (2004–2024) |
| title_full | Exploring the role of protein palmitoylation in cancer progression and therapy: a comprehensive bibliometric study (2004–2024) |
| title_fullStr | Exploring the role of protein palmitoylation in cancer progression and therapy: a comprehensive bibliometric study (2004–2024) |
| title_full_unstemmed | Exploring the role of protein palmitoylation in cancer progression and therapy: a comprehensive bibliometric study (2004–2024) |
| title_short | Exploring the role of protein palmitoylation in cancer progression and therapy: a comprehensive bibliometric study (2004–2024) |
| title_sort | exploring the role of protein palmitoylation in cancer progression and therapy a comprehensive bibliometric study 2004 2024 |
| topic | Palmitoylation Cancer Metabolic reprogramming Immunotherapy Bibliometrics |
| url | https://doi.org/10.1007/s12672-025-03059-0 |
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