Research hotspots of irisin in the nervous system: a bibliometric study and visualization analysis via CiteSpace
ObjectiveTo visually analyze the current status, hotspots, and frontiers of irisin in the nervous system and to provide a reference for future clinical research.MethodsWeb of Science Core Collection (WoSCC), PubMed, Embase, and Cochrane Library databases were searched for studies on the mechanism of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1488559/full |
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| author | Jiacheng Wang Jiacheng Wang Juan Liu Juan Liu Wei Pang Wei Pang Wei Pang Xin Li Xin Li Xin Li Xinping Huang Shan Wang Shan Wang Chunxiao Nan Chunxiao Nan |
| author_facet | Jiacheng Wang Jiacheng Wang Juan Liu Juan Liu Wei Pang Wei Pang Wei Pang Xin Li Xin Li Xin Li Xinping Huang Shan Wang Shan Wang Chunxiao Nan Chunxiao Nan |
| author_sort | Jiacheng Wang |
| collection | DOAJ |
| description | ObjectiveTo visually analyze the current status, hotspots, and frontiers of irisin in the nervous system and to provide a reference for future clinical research.MethodsWeb of Science Core Collection (WoSCC), PubMed, Embase, and Cochrane Library databases were searched for studies on the mechanism of irisin on the nervous system published from January 1st, 2012 to April 15th, 2025. CiteSpace 6.4.R1 and Excel 2021 software were used to visualize the knowledge map of the annual number of publications, research institutions, countries, co-cited literature, journal dual map overlays, and keywords of the sample literature.ResultsFour hundred and ninety-eight were included, and the annual number of articles showed an overall upward trend. The institution with the most significant number of articles was the Universidade Federal do Rio de Janeiro (UFRJ), and the country with the most significant number of articles was China. The prevalent keywords were “Exercise,” “Skeletal muscle,” “Neurotrophic factor,” “Expression,” “Alzheimer’s disease,” indicating that the production of irisin and its protective mechanisms for the nervous system are research hotspots in this field. Cluster analysis showed that the research frontier hotspots in this field could focus on three main topics: the functional role and mechanism of irisin, pathological experimental research, and clinical disease research.ConclusionIn recent years, research on irisin in the nervous system has primarily centered on elucidating its neuronal regulatory mechanisms and neuroprotective effects, along with their potential applications in neurological disorders. Future investigations should aim to delineate novel signaling pathways and action mechanisms and systematically identify therapeutic targets for refractory neurological conditions through comprehensive translational studies. |
| format | Article |
| id | doaj-art-4999080c0db042cdbc623c82f9cfe2f5 |
| institution | DOAJ |
| issn | 1663-4365 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-4999080c0db042cdbc623c82f9cfe2f52025-08-20T03:07:58ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652025-05-011710.3389/fnagi.2025.14885591488559Research hotspots of irisin in the nervous system: a bibliometric study and visualization analysis via CiteSpaceJiacheng Wang0Jiacheng Wang1Juan Liu2Juan Liu3Wei Pang4Wei Pang5Wei Pang6Xin Li7Xin Li8Xin Li9Xinping Huang10Shan Wang11Shan Wang12Chunxiao Nan13Chunxiao Nan14College of Rehabilitation Medicine, Jiamusi University, Jiamusi, Heilongjiang, ChinaChildren Rehabilitation Nerve Laboratory, Jiamusi University, Jiamusi, Heilongjiang, ChinaCollege of Rehabilitation Medicine, Jiamusi University, Jiamusi, Heilongjiang, ChinaChildren Rehabilitation Nerve Laboratory, Jiamusi University, Jiamusi, Heilongjiang, ChinaCollege of Rehabilitation Medicine, Jiamusi University, Jiamusi, Heilongjiang, ChinaChildren Rehabilitation Nerve Laboratory, Jiamusi University, Jiamusi, Heilongjiang, ChinaThe Third Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang, ChinaCollege of Rehabilitation Medicine, Jiamusi University, Jiamusi, Heilongjiang, ChinaChildren Rehabilitation Nerve Laboratory, Jiamusi University, Jiamusi, Heilongjiang, ChinaThe Third Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang, ChinaNingbo Rehabilitation Hospital, Ningbo, Zhejiang, ChinaCollege of Rehabilitation Medicine, Jiamusi University, Jiamusi, Heilongjiang, ChinaChildren Rehabilitation Nerve Laboratory, Jiamusi University, Jiamusi, Heilongjiang, ChinaCollege of Rehabilitation Medicine, Jiamusi University, Jiamusi, Heilongjiang, ChinaChildren Rehabilitation Nerve Laboratory, Jiamusi University, Jiamusi, Heilongjiang, ChinaObjectiveTo visually analyze the current status, hotspots, and frontiers of irisin in the nervous system and to provide a reference for future clinical research.MethodsWeb of Science Core Collection (WoSCC), PubMed, Embase, and Cochrane Library databases were searched for studies on the mechanism of irisin on the nervous system published from January 1st, 2012 to April 15th, 2025. CiteSpace 6.4.R1 and Excel 2021 software were used to visualize the knowledge map of the annual number of publications, research institutions, countries, co-cited literature, journal dual map overlays, and keywords of the sample literature.ResultsFour hundred and ninety-eight were included, and the annual number of articles showed an overall upward trend. The institution with the most significant number of articles was the Universidade Federal do Rio de Janeiro (UFRJ), and the country with the most significant number of articles was China. The prevalent keywords were “Exercise,” “Skeletal muscle,” “Neurotrophic factor,” “Expression,” “Alzheimer’s disease,” indicating that the production of irisin and its protective mechanisms for the nervous system are research hotspots in this field. Cluster analysis showed that the research frontier hotspots in this field could focus on three main topics: the functional role and mechanism of irisin, pathological experimental research, and clinical disease research.ConclusionIn recent years, research on irisin in the nervous system has primarily centered on elucidating its neuronal regulatory mechanisms and neuroprotective effects, along with their potential applications in neurological disorders. Future investigations should aim to delineate novel signaling pathways and action mechanisms and systematically identify therapeutic targets for refractory neurological conditions through comprehensive translational studies.https://www.frontiersin.org/articles/10.3389/fnagi.2025.1488559/fullirisinnervous systemneuroprotectionCiteSpacevisualization analysisbibliometric study |
| spellingShingle | Jiacheng Wang Jiacheng Wang Juan Liu Juan Liu Wei Pang Wei Pang Wei Pang Xin Li Xin Li Xin Li Xinping Huang Shan Wang Shan Wang Chunxiao Nan Chunxiao Nan Research hotspots of irisin in the nervous system: a bibliometric study and visualization analysis via CiteSpace Frontiers in Aging Neuroscience irisin nervous system neuroprotection CiteSpace visualization analysis bibliometric study |
| title | Research hotspots of irisin in the nervous system: a bibliometric study and visualization analysis via CiteSpace |
| title_full | Research hotspots of irisin in the nervous system: a bibliometric study and visualization analysis via CiteSpace |
| title_fullStr | Research hotspots of irisin in the nervous system: a bibliometric study and visualization analysis via CiteSpace |
| title_full_unstemmed | Research hotspots of irisin in the nervous system: a bibliometric study and visualization analysis via CiteSpace |
| title_short | Research hotspots of irisin in the nervous system: a bibliometric study and visualization analysis via CiteSpace |
| title_sort | research hotspots of irisin in the nervous system a bibliometric study and visualization analysis via citespace |
| topic | irisin nervous system neuroprotection CiteSpace visualization analysis bibliometric study |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1488559/full |
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