Rediscovery of PHI-1/PPP1R14B: Emerging Roles of Cellular PP1 Signaling Mediated by the <i>PPP1R14B</i> Gene Product in Multiple Cancers and Beyond
PHI-1, encoded by <i>PPP1R14B</i>, regulates cellular protein phosphatase-1 (PP1) signaling and has emerged as both a biomarker and therapeutic target. Initially identified as a phospholipase-neighboring gene (PNG), PHI-1 is now known for its phosphorylation-dependent inhibition of PP1 h...
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MDPI AG
2025-02-01
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| Online Access: | https://www.mdpi.com/2218-273X/15/3/344 |
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| author | Masumi Eto |
| author_facet | Masumi Eto |
| author_sort | Masumi Eto |
| collection | DOAJ |
| description | PHI-1, encoded by <i>PPP1R14B</i>, regulates cellular protein phosphatase-1 (PP1) signaling and has emerged as both a biomarker and therapeutic target. Initially identified as a phospholipase-neighboring gene (PNG), PHI-1 is now known for its phosphorylation-dependent inhibition of PP1 holoenzymes, with bi-directional roles depending on its expression levels. Under physiological conditions, PHI-1 selectively regulates PP1 activity to maintain cellular homeostasis, whereas its pathological upregulation promotes oncogenic pathways, stabilizes tumor-promoting proteins, and modulates immune responses. This article explores PHI-1’s emerging role as a pan-cancer biomarker in parallel with emphasizing its physiological functions in signaling networks, smooth muscle contraction, cytoskeletal dynamics, and selective proteostasis. The mechanistic insights highlight PHI-1’s potential in precision oncology, offering opportunities for developing diagnostics and therapies that target its conditional functions. |
| format | Article |
| id | doaj-art-49948ecc6854477ea65872f0bb3688e7 |
| institution | OA Journals |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-49948ecc6854477ea65872f0bb3688e72025-08-20T02:11:09ZengMDPI AGBiomolecules2218-273X2025-02-0115334410.3390/biom15030344Rediscovery of PHI-1/PPP1R14B: Emerging Roles of Cellular PP1 Signaling Mediated by the <i>PPP1R14B</i> Gene Product in Multiple Cancers and BeyondMasumi Eto0Graduate School of Veterinary Science, Okayama University of Science, Imabari 794-8555, Ehime, JapanPHI-1, encoded by <i>PPP1R14B</i>, regulates cellular protein phosphatase-1 (PP1) signaling and has emerged as both a biomarker and therapeutic target. Initially identified as a phospholipase-neighboring gene (PNG), PHI-1 is now known for its phosphorylation-dependent inhibition of PP1 holoenzymes, with bi-directional roles depending on its expression levels. Under physiological conditions, PHI-1 selectively regulates PP1 activity to maintain cellular homeostasis, whereas its pathological upregulation promotes oncogenic pathways, stabilizes tumor-promoting proteins, and modulates immune responses. This article explores PHI-1’s emerging role as a pan-cancer biomarker in parallel with emphasizing its physiological functions in signaling networks, smooth muscle contraction, cytoskeletal dynamics, and selective proteostasis. The mechanistic insights highlight PHI-1’s potential in precision oncology, offering opportunities for developing diagnostics and therapies that target its conditional functions.https://www.mdpi.com/2218-273X/15/3/344cancer diagnosisprognostic assessmentprotein phosphatase-1cell signalingproteostasis |
| spellingShingle | Masumi Eto Rediscovery of PHI-1/PPP1R14B: Emerging Roles of Cellular PP1 Signaling Mediated by the <i>PPP1R14B</i> Gene Product in Multiple Cancers and Beyond Biomolecules cancer diagnosis prognostic assessment protein phosphatase-1 cell signaling proteostasis |
| title | Rediscovery of PHI-1/PPP1R14B: Emerging Roles of Cellular PP1 Signaling Mediated by the <i>PPP1R14B</i> Gene Product in Multiple Cancers and Beyond |
| title_full | Rediscovery of PHI-1/PPP1R14B: Emerging Roles of Cellular PP1 Signaling Mediated by the <i>PPP1R14B</i> Gene Product in Multiple Cancers and Beyond |
| title_fullStr | Rediscovery of PHI-1/PPP1R14B: Emerging Roles of Cellular PP1 Signaling Mediated by the <i>PPP1R14B</i> Gene Product in Multiple Cancers and Beyond |
| title_full_unstemmed | Rediscovery of PHI-1/PPP1R14B: Emerging Roles of Cellular PP1 Signaling Mediated by the <i>PPP1R14B</i> Gene Product in Multiple Cancers and Beyond |
| title_short | Rediscovery of PHI-1/PPP1R14B: Emerging Roles of Cellular PP1 Signaling Mediated by the <i>PPP1R14B</i> Gene Product in Multiple Cancers and Beyond |
| title_sort | rediscovery of phi 1 ppp1r14b emerging roles of cellular pp1 signaling mediated by the i ppp1r14b i gene product in multiple cancers and beyond |
| topic | cancer diagnosis prognostic assessment protein phosphatase-1 cell signaling proteostasis |
| url | https://www.mdpi.com/2218-273X/15/3/344 |
| work_keys_str_mv | AT masumieto rediscoveryofphi1ppp1r14bemergingrolesofcellularpp1signalingmediatedbytheippp1r14bigeneproductinmultiplecancersandbeyond |