Heparprotective effect of <i>Bergenia crassifolia </i>extract and silymarinat experimental inhibition of β-oxidation of fatty acids causedby 4-pentenioc acid
The object of this research was to study rat liver bioenergetics at pathology caused by inhibition of β-oxidation of fatty acids against the background of 4-pentenoic acid injection and at silymarin and Bergenia crassifolia extract therapy. The experiment was conducted with 50 nonpedigreed male rats...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2007-12-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/3320 |
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| author | D. V. Shutov |
| author_facet | D. V. Shutov |
| author_sort | D. V. Shutov |
| collection | DOAJ |
| description | The object of this research was to study rat liver bioenergetics at pathology caused by inhibition of β-oxidation of fatty acids against the background of 4-pentenoic acid injection and at silymarin and Bergenia crassifolia extract therapy. The experiment was conducted with 50 nonpedigreed male rats. The functional state of the energy production system was estimated by the polarogaphic method from the rate of oxygen consumption in different Chans metabolic states. At silymarin therapy, increase was observed in the oxidative phosphorylation coupling in all metabolic states. The Bergenia crassifolia extract favored normalization of energy production parameters in rat liver mitochondria more efficiently than silymarint did. |
| format | Article |
| id | doaj-art-49919b64c1d14476a656ecf1b699a396 |
| institution | Kabale University |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2007-12-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-49919b64c1d14476a656ecf1b699a3962025-08-20T03:38:09ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842007-12-0164647010.20538/1682-0363-2007-4-64-701976Heparprotective effect of <i>Bergenia crassifolia </i>extract and silymarinat experimental inhibition of β-oxidation of fatty acids causedby 4-pentenioc acidD. V. Shutov0Сибирский государственный медицинский университет, г. ТомскThe object of this research was to study rat liver bioenergetics at pathology caused by inhibition of β-oxidation of fatty acids against the background of 4-pentenoic acid injection and at silymarin and Bergenia crassifolia extract therapy. The experiment was conducted with 50 nonpedigreed male rats. The functional state of the energy production system was estimated by the polarogaphic method from the rate of oxygen consumption in different Chans metabolic states. At silymarin therapy, increase was observed in the oxidative phosphorylation coupling in all metabolic states. The Bergenia crassifolia extract favored normalization of energy production parameters in rat liver mitochondria more efficiently than silymarint did.https://bulletin.ssmu.ru/jour/article/view/3320liver mitochondriasilymarin<i>berginia crassifolia </i>extract4-pentenoic acid |
| spellingShingle | D. V. Shutov Heparprotective effect of <i>Bergenia crassifolia </i>extract and silymarinat experimental inhibition of β-oxidation of fatty acids causedby 4-pentenioc acid Бюллетень сибирской медицины liver mitochondria silymarin <i>berginia crassifolia </i>extract 4-pentenoic acid |
| title | Heparprotective effect of <i>Bergenia crassifolia </i>extract and silymarinat experimental inhibition of β-oxidation of fatty acids causedby 4-pentenioc acid |
| title_full | Heparprotective effect of <i>Bergenia crassifolia </i>extract and silymarinat experimental inhibition of β-oxidation of fatty acids causedby 4-pentenioc acid |
| title_fullStr | Heparprotective effect of <i>Bergenia crassifolia </i>extract and silymarinat experimental inhibition of β-oxidation of fatty acids causedby 4-pentenioc acid |
| title_full_unstemmed | Heparprotective effect of <i>Bergenia crassifolia </i>extract and silymarinat experimental inhibition of β-oxidation of fatty acids causedby 4-pentenioc acid |
| title_short | Heparprotective effect of <i>Bergenia crassifolia </i>extract and silymarinat experimental inhibition of β-oxidation of fatty acids causedby 4-pentenioc acid |
| title_sort | heparprotective effect of i bergenia crassifolia i extract and silymarinat experimental inhibition of β oxidation of fatty acids causedby 4 pentenioc acid |
| topic | liver mitochondria silymarin <i>berginia crassifolia </i>extract 4-pentenoic acid |
| url | https://bulletin.ssmu.ru/jour/article/view/3320 |
| work_keys_str_mv | AT dvshutov heparprotectiveeffectofibergeniacrassifoliaiextractandsilymarinatexperimentalinhibitionofboxidationoffattyacidscausedby4penteniocacid |