Design and synthesis of a novel quinoline thiazolidinedione hybrid as a potential antidiabetic PPARγ modulator

Design and synthesis of a novel quinoline thiazolidinedione hybrid as a potential antidiabetic PPARγ modulator

Abstract Peroxisome proliferator-activated receptor γ (PPARγ) remains a critical target for antidiabetic drug development due to its role in glucose and lipid metabolism. However, the adverse effects associated with full agonists of the thiazolidinedione (TZD) class, such as weight gain and hepatoto...

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Bibliographic Details
Main Authors: Ayman M. Ibrahim, Mai E. Shoman, Radwa Taher Mohie el-dien, Entesar Ali Saber, Mahmoud Abdelnaser, Sherif A. Maher, Alaa M. Hayallah, Mahmoud Abdul-Aziz El-Rehany, Gamal El-Din A. Abuo-Rahma
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Quinoline
Thiazolidinedione
PPARγ
Antidiabetic
SPPARMs
Online Access:https://doi.org/10.1038/s41598-025-03387-9
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