Determination of pKA of nonvolatile weak acids in plasma of healthy volunteers and critically ill patients

Determination of pKA of nonvolatile weak acids in plasma of healthy volunteers and critically ill patients

Abstract Background The dissociation constant of nonvolatile weak acids in plasma (KA), expressed as pKA, is essential for electroneutrality-based acid–base analysis. To date, its normal value in human plasma has been determined in only one study involving eight healthy volunteers. We hypothesized t...

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Bibliographic Details
Main Authors: Martin Krbec, Serena Brusatori, Petr Waldauf, Alberto Zanella, Francesco Zadek, Victor van Bochove, František Duška, Thomas Langer, Paul Elbers
Format: Article
Language:English
Published: SpringerOpen 2025-06-01
Series:Intensive Care Medicine Experimental
Subjects:
Acid–base equilibrium
Models
Theoretical
Acids
Serum albumin
Hydrogen-ion concentration
Online Access:https://doi.org/10.1186/s40635-025-00762-8
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