Bio-inspired natural fibers-derived e-skin equipped with intelligent drug-release system for advanced robustly-integrated melanoma therapy
Abstract Malignant melanoma, a highly aggressive malignancy, necessitates innovative therapeutic strategies integrating biomaterial innovation with multimodal treatment modalities. Herein, we report the development of a collagen-derived bioelectronic skin (c-ADM) nanoengineered via interfacial assem...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-08-01
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| Series: | Collagen and Leather |
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| Online Access: | https://doi.org/10.1186/s42825-025-00210-z |
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| author | Xinhua Liu Yifan Fei Boqiang Cui Xing Chen Jiamin Zhang Ouyang Yue Zhongxue Bai Ling Wen Huie Jiang |
| author_facet | Xinhua Liu Yifan Fei Boqiang Cui Xing Chen Jiamin Zhang Ouyang Yue Zhongxue Bai Ling Wen Huie Jiang |
| author_sort | Xinhua Liu |
| collection | DOAJ |
| description | Abstract Malignant melanoma, a highly aggressive malignancy, necessitates innovative therapeutic strategies integrating biomaterial innovation with multimodal treatment modalities. Herein, we report the development of a collagen-derived bioelectronic skin (c-ADM) nanoengineered via interfacial assembly of porcine acellular dermal matrix (ADM)—a natural collagen-rich scaffold—with conductive poly (3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) and copper sulfide nanoparticles (CuS-NPs). This hybrid system synergizes photothermal ablation, stimuli-responsive drug delivery, and electrostimulation (ES) for comprehensive postoperative melanoma management and tissue regeneration. The c-ADM platform exhibits superior mechanical robustness, enzymatic resistance, and biocompatibility, enabling real-time motion monitoring while maintaining structural integrity in dynamic physiological environments. Leveraging the photothermal efficiency of CuS-NPs, localized hyperthermia (ΔT > 40 °C) under near-infrared (NIR) irradiation induces irreversible melanoma cell apoptosis. Concurrently, laser-triggered temperature-responsive drug release enables synchronized photothermal-chemotherapy, with sustained doxorubicin release profiles at tumor sites. Notably, pH-responsive Cu2⁺ liberation from CuS-NPs facilitates intelligent functional switching: bactericidal activity at tumor microenvironment pH (5.0–6.0) and pro-regenerative effects under physiological pH (7.4) for wound healing. In vitro/in vivo assessments confirm c-ADM’s dual therapeutic efficacy including ES-enhanced cancer cell death via mitochondrial dysfunction and accelerated full-thickness skin regeneration through collagen remodeling and angiogenesis modulation. This work establishes a collagen-based bioelectronic scaffold for personalized oncological care, integrating intraoperative tumor eradication, postoperative surveillance, and adaptive tissue reconstruction. Graphic Abstract |
| format | Article |
| id | doaj-art-4988f0cee2894710bf1ba1bcaa032a0f |
| institution | DOAJ |
| issn | 2097-1419 2731-6998 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Collagen and Leather |
| spelling | doaj-art-4988f0cee2894710bf1ba1bcaa032a0f2025-08-20T03:06:05ZengSpringerOpenCollagen and Leather2097-14192731-69982025-08-017112510.1186/s42825-025-00210-zBio-inspired natural fibers-derived e-skin equipped with intelligent drug-release system for advanced robustly-integrated melanoma therapyXinhua Liu0Yifan Fei1Boqiang Cui2Xing Chen3Jiamin Zhang4Ouyang Yue5Zhongxue Bai6Ling Wen7Huie Jiang8College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science & TechnologyCollege of Bioresources Chemical and Materials Engineering, Shaanxi University of Science & TechnologyCollege of Bioresources Chemical and Materials Engineering, Shaanxi University of Science & TechnologyCollege of Bioresources Chemical and Materials Engineering, Shaanxi University of Science & TechnologyCollege of Bioresources Chemical and Materials Engineering, Shaanxi University of Science & TechnologyCollege of Bioresources Chemical and Materials Engineering, Shaanxi University of Science & TechnologyCollege of Bioresources Chemical and Materials Engineering, Shaanxi University of Science & TechnologyDepartment of Radiology, Dushu Lake Hospital Affiliated to Soochow University, Medical Center of Soochow UniversityCollege of Bioresources Chemical and Materials Engineering, Shaanxi University of Science & TechnologyAbstract Malignant melanoma, a highly aggressive malignancy, necessitates innovative therapeutic strategies integrating biomaterial innovation with multimodal treatment modalities. Herein, we report the development of a collagen-derived bioelectronic skin (c-ADM) nanoengineered via interfacial assembly of porcine acellular dermal matrix (ADM)—a natural collagen-rich scaffold—with conductive poly (3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) and copper sulfide nanoparticles (CuS-NPs). This hybrid system synergizes photothermal ablation, stimuli-responsive drug delivery, and electrostimulation (ES) for comprehensive postoperative melanoma management and tissue regeneration. The c-ADM platform exhibits superior mechanical robustness, enzymatic resistance, and biocompatibility, enabling real-time motion monitoring while maintaining structural integrity in dynamic physiological environments. Leveraging the photothermal efficiency of CuS-NPs, localized hyperthermia (ΔT > 40 °C) under near-infrared (NIR) irradiation induces irreversible melanoma cell apoptosis. Concurrently, laser-triggered temperature-responsive drug release enables synchronized photothermal-chemotherapy, with sustained doxorubicin release profiles at tumor sites. Notably, pH-responsive Cu2⁺ liberation from CuS-NPs facilitates intelligent functional switching: bactericidal activity at tumor microenvironment pH (5.0–6.0) and pro-regenerative effects under physiological pH (7.4) for wound healing. In vitro/in vivo assessments confirm c-ADM’s dual therapeutic efficacy including ES-enhanced cancer cell death via mitochondrial dysfunction and accelerated full-thickness skin regeneration through collagen remodeling and angiogenesis modulation. This work establishes a collagen-based bioelectronic scaffold for personalized oncological care, integrating intraoperative tumor eradication, postoperative surveillance, and adaptive tissue reconstruction. Graphic Abstracthttps://doi.org/10.1186/s42825-025-00210-zNature fibersAcellular dermal matrixBioelectronic skinCopper nanomaterialsWound healing |
| spellingShingle | Xinhua Liu Yifan Fei Boqiang Cui Xing Chen Jiamin Zhang Ouyang Yue Zhongxue Bai Ling Wen Huie Jiang Bio-inspired natural fibers-derived e-skin equipped with intelligent drug-release system for advanced robustly-integrated melanoma therapy Collagen and Leather Nature fibers Acellular dermal matrix Bioelectronic skin Copper nanomaterials Wound healing |
| title | Bio-inspired natural fibers-derived e-skin equipped with intelligent drug-release system for advanced robustly-integrated melanoma therapy |
| title_full | Bio-inspired natural fibers-derived e-skin equipped with intelligent drug-release system for advanced robustly-integrated melanoma therapy |
| title_fullStr | Bio-inspired natural fibers-derived e-skin equipped with intelligent drug-release system for advanced robustly-integrated melanoma therapy |
| title_full_unstemmed | Bio-inspired natural fibers-derived e-skin equipped with intelligent drug-release system for advanced robustly-integrated melanoma therapy |
| title_short | Bio-inspired natural fibers-derived e-skin equipped with intelligent drug-release system for advanced robustly-integrated melanoma therapy |
| title_sort | bio inspired natural fibers derived e skin equipped with intelligent drug release system for advanced robustly integrated melanoma therapy |
| topic | Nature fibers Acellular dermal matrix Bioelectronic skin Copper nanomaterials Wound healing |
| url | https://doi.org/10.1186/s42825-025-00210-z |
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