Nanotechnology in the Treatment of Glioblastoma Multiforme: Enhancing Radiotherapy and Chemotherapy with Nanoparticles
Introduction: Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor, associated with poor prognosis despite standard treatment modalities including surgery, radiotherapy, and chemotherapy. The limited efficacy of these therapies is due, in part, to the difficulty of complete...
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| Format: | Article |
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Kazimierz Wielki University
2025-05-01
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| Series: | Journal of Education, Health and Sport |
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| Online Access: | https://apcz.umk.pl/JEHS/article/view/60160 |
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| author | Emilia Gabriela Chrzanowska Jakub Paweł Kuźniar Julia Szlążek Adam Jan Ząbek Michalina Zagalska Marta Turek Tomasz Tamborski Adam Grzebinoga Barbara Roguska Michał Kuźniar |
| author_facet | Emilia Gabriela Chrzanowska Jakub Paweł Kuźniar Julia Szlążek Adam Jan Ząbek Michalina Zagalska Marta Turek Tomasz Tamborski Adam Grzebinoga Barbara Roguska Michał Kuźniar |
| author_sort | Emilia Gabriela Chrzanowska |
| collection | DOAJ |
| description |
Introduction:
Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor, associated with poor prognosis despite standard treatment modalities including surgery, radiotherapy, and chemotherapy. The limited efficacy of these therapies is due, in part, to the difficulty of complete tumor resection, the blood-brain barrier (BBB) hindering drug penetration, and the tumor’s resistance mechanisms to chemotherapy and radiotherapy. Nanoparticles (NPs) offer promising solutions for targeted drug delivery, potentially improving therapeutic outcomes. This review summarizes recent advances in nanoparticle-based therapies for GBM.
Methods:
A literature review was conducted by analyzing 38 scientific articles using PubMed and Google Scholar databases. Studies published within the last five years focusing on the application of nanoparticles in GBM treatment were included. Various types of nanoparticles, their mechanisms of action, and the potential benefits and limitations of their clinical use were discussed.
Results:
The literature indicates that nanoparticles enhance drug permeability across the BBB, improve tumor penetration, and increase treatment efficacy. Their use in GBM therapy enables more precise drug delivery, reduces systemic toxicity, and minimizes damage to healthy tissues. Furthermore, nanoparticles play a significant role in combination therapies, potentially leading to a synergistic therapeutic effect.
Conclusions:
Nanoparticles represent a novel and promising strategy for the treatment of GBM, offering targeted drug delivery and improved therapeutic outcomes. However, further research is needed to optimize nanoparticle formulations and to evaluate their long-term safety and efficacy in clinical settings.
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| format | Article |
| id | doaj-art-4982f1c6b0cb4b3397a97dc899c58bbd |
| institution | OA Journals |
| issn | 2391-8306 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj-art-4982f1c6b0cb4b3397a97dc899c58bbd2025-08-20T02:26:16ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062025-05-018010.12775/JEHS.2025.80.60160Nanotechnology in the Treatment of Glioblastoma Multiforme: Enhancing Radiotherapy and Chemotherapy with NanoparticlesEmilia Gabriela Chrzanowska0https://orcid.org/0009-0001-6228-1878Jakub Paweł Kuźniar1https://orcid.org/0009-0002-6716-7502Julia Szlążek2https://orcid.org/0009-0007-6977-8856Adam Jan Ząbek3https://orcid.org/0009-0003-6799-1814Michalina Zagalska4https://orcid.org/0009-0002-7312-0065Marta Turek5https://orcid.org/0009-0005-7713-6875Tomasz Tamborski6https://orcid.org/0009-0003-6275-1010Adam Grzebinoga7https://orcid.org/0009-0001-5983-7564Barbara Roguska8https://orcid.org/0009-0006-6905-7517Michał Kuźniar9https://orcid.org/0009-0000-9224-9636Medical University of Silesia, 18 Medyków Street 40-752 KatowiceThe Provincial Hospital in Bielsko-Biała, 101 Armii Krajowej Ave., 43-316 Bielsko BiałaMedical University of Silesia, 18 Medyków Street, 40-752 KatowiceKatowice Oncology Center, 26 Raciborska Street, 40-074 KatowiceIndependent Public Clinical Hospital named Andrzej Mielęcki of the Silesian Medical University in Katowice, 20-24 Francuska Street, 40-027 KatowiceIndependent Public Clinical Hospital named Andrzej Mielęcki of the Silesian Medical University in Katowice, 20-24 Francuska Street, 40-027 Katowice County Hospital in Zawiercie, 14 Miodowa Street, 42-400 ZawiercieUniversity Clinical Center of Prof. K. Gibiński of the Silesian Medical University in Katowice, 14 Medyków Street, 40-752 KatowiceMedical University of Silesia, 18 Medyków Street, 40-752 KatowiceJagiellonian University Medical College, 12 Świętej Anny Street, 31-008 Kraków Introduction: Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor, associated with poor prognosis despite standard treatment modalities including surgery, radiotherapy, and chemotherapy. The limited efficacy of these therapies is due, in part, to the difficulty of complete tumor resection, the blood-brain barrier (BBB) hindering drug penetration, and the tumor’s resistance mechanisms to chemotherapy and radiotherapy. Nanoparticles (NPs) offer promising solutions for targeted drug delivery, potentially improving therapeutic outcomes. This review summarizes recent advances in nanoparticle-based therapies for GBM. Methods: A literature review was conducted by analyzing 38 scientific articles using PubMed and Google Scholar databases. Studies published within the last five years focusing on the application of nanoparticles in GBM treatment were included. Various types of nanoparticles, their mechanisms of action, and the potential benefits and limitations of their clinical use were discussed. Results: The literature indicates that nanoparticles enhance drug permeability across the BBB, improve tumor penetration, and increase treatment efficacy. Their use in GBM therapy enables more precise drug delivery, reduces systemic toxicity, and minimizes damage to healthy tissues. Furthermore, nanoparticles play a significant role in combination therapies, potentially leading to a synergistic therapeutic effect. Conclusions: Nanoparticles represent a novel and promising strategy for the treatment of GBM, offering targeted drug delivery and improved therapeutic outcomes. However, further research is needed to optimize nanoparticle formulations and to evaluate their long-term safety and efficacy in clinical settings. https://apcz.umk.pl/JEHS/article/view/60160Glioblastoma multiformenanoparticlesdrug deliveryblood-brain barriertargeted therapynanomedicine |
| spellingShingle | Emilia Gabriela Chrzanowska Jakub Paweł Kuźniar Julia Szlążek Adam Jan Ząbek Michalina Zagalska Marta Turek Tomasz Tamborski Adam Grzebinoga Barbara Roguska Michał Kuźniar Nanotechnology in the Treatment of Glioblastoma Multiforme: Enhancing Radiotherapy and Chemotherapy with Nanoparticles Journal of Education, Health and Sport Glioblastoma multiforme nanoparticles drug delivery blood-brain barrier targeted therapy nanomedicine |
| title | Nanotechnology in the Treatment of Glioblastoma Multiforme: Enhancing Radiotherapy and Chemotherapy with Nanoparticles |
| title_full | Nanotechnology in the Treatment of Glioblastoma Multiforme: Enhancing Radiotherapy and Chemotherapy with Nanoparticles |
| title_fullStr | Nanotechnology in the Treatment of Glioblastoma Multiforme: Enhancing Radiotherapy and Chemotherapy with Nanoparticles |
| title_full_unstemmed | Nanotechnology in the Treatment of Glioblastoma Multiforme: Enhancing Radiotherapy and Chemotherapy with Nanoparticles |
| title_short | Nanotechnology in the Treatment of Glioblastoma Multiforme: Enhancing Radiotherapy and Chemotherapy with Nanoparticles |
| title_sort | nanotechnology in the treatment of glioblastoma multiforme enhancing radiotherapy and chemotherapy with nanoparticles |
| topic | Glioblastoma multiforme nanoparticles drug delivery blood-brain barrier targeted therapy nanomedicine |
| url | https://apcz.umk.pl/JEHS/article/view/60160 |
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