Growth Differentiation Factor-15: One of the Missing Links between Psoriasis and Metabolic Syndrome
Background: Psoriasis is a chronic inflammatory condition of the skin that can be related to a variety of other conditions, including cardiovascular disease and metabolic syndrome. Growth differentiation factor-15 (GDF-15) is a cytokine that reacts to cellular stress. GDF-15 serum levels may have cl...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-05-01
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| Series: | Indian Dermatology Online Journal |
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| Online Access: | https://journals.lww.com/10.4103/idoj.idoj_546_24 |
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| author | Essam M. Akl Nehad A. Fouad Maram S. Mahmoud Karem T. Khalil |
| author_facet | Essam M. Akl Nehad A. Fouad Maram S. Mahmoud Karem T. Khalil |
| author_sort | Essam M. Akl |
| collection | DOAJ |
| description | Background:
Psoriasis is a chronic inflammatory condition of the skin that can be related to a variety of other conditions, including cardiovascular disease and metabolic syndrome. Growth differentiation factor-15 (GDF-15) is a cytokine that reacts to cellular stress. GDF-15 serum levels may have clinical uses in a variety of inflammatory and cardiovascular conditions.
Objectives:
To determine the levels of GDF-15 in the serum of patients with generalized plaque psoriasis (GPP) and its correlation with the metabolic syndrome.
Patients and Methods:
This case-control study included 50 patients with GPP and 50 age- and sex-matched healthy volunteers as controls. A general examination was performed, with a particular emphasis on measurements of body mass index, circumference of the waist, and blood pressure. Psoriasis severity was assessed using the Psoriasis Area and Severity Index (PASI) score. In addition, laboratory tests, including fasting blood sugar, lipid profile, and serum GDF-15 level measurement, were made.
Results:
Patients had significantly higher median GDF-15 levels compared to controls (P < 0.001). GDF-15 showed a substantial correlation with both disease duration and PASI score (P < 0.001 for each). GDF-15 levels were considerably greater in participants with metabolic syndrome compared with those without (P = 0.01).
Limitation:
The relatively small sample size could be a disadvantage and drawback of the study.
Conclusion:
Serum GDF-15 levels are linked to the severity of psoriasis and the associated metabolic disorders. |
| format | Article |
| id | doaj-art-49802a49ee1a41f39e676099fc936656 |
| institution | DOAJ |
| issn | 2229-5178 2249-5673 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Dermatology Online Journal |
| spelling | doaj-art-49802a49ee1a41f39e676099fc9366562025-08-20T02:56:59ZengWolters Kluwer Medknow PublicationsIndian Dermatology Online Journal2229-51782249-56732025-05-0116339740110.4103/idoj.idoj_546_24Growth Differentiation Factor-15: One of the Missing Links between Psoriasis and Metabolic SyndromeEssam M. AklNehad A. FouadMaram S. MahmoudKarem T. KhalilBackground: Psoriasis is a chronic inflammatory condition of the skin that can be related to a variety of other conditions, including cardiovascular disease and metabolic syndrome. Growth differentiation factor-15 (GDF-15) is a cytokine that reacts to cellular stress. GDF-15 serum levels may have clinical uses in a variety of inflammatory and cardiovascular conditions. Objectives: To determine the levels of GDF-15 in the serum of patients with generalized plaque psoriasis (GPP) and its correlation with the metabolic syndrome. Patients and Methods: This case-control study included 50 patients with GPP and 50 age- and sex-matched healthy volunteers as controls. A general examination was performed, with a particular emphasis on measurements of body mass index, circumference of the waist, and blood pressure. Psoriasis severity was assessed using the Psoriasis Area and Severity Index (PASI) score. In addition, laboratory tests, including fasting blood sugar, lipid profile, and serum GDF-15 level measurement, were made. Results: Patients had significantly higher median GDF-15 levels compared to controls (P < 0.001). GDF-15 showed a substantial correlation with both disease duration and PASI score (P < 0.001 for each). GDF-15 levels were considerably greater in participants with metabolic syndrome compared with those without (P = 0.01). Limitation: The relatively small sample size could be a disadvantage and drawback of the study. Conclusion: Serum GDF-15 levels are linked to the severity of psoriasis and the associated metabolic disorders.https://journals.lww.com/10.4103/idoj.idoj_546_24growth differentiation factor-15metabolic syndromepsoriasis |
| spellingShingle | Essam M. Akl Nehad A. Fouad Maram S. Mahmoud Karem T. Khalil Growth Differentiation Factor-15: One of the Missing Links between Psoriasis and Metabolic Syndrome Indian Dermatology Online Journal growth differentiation factor-15 metabolic syndrome psoriasis |
| title | Growth Differentiation Factor-15: One of the Missing Links between Psoriasis and Metabolic Syndrome |
| title_full | Growth Differentiation Factor-15: One of the Missing Links between Psoriasis and Metabolic Syndrome |
| title_fullStr | Growth Differentiation Factor-15: One of the Missing Links between Psoriasis and Metabolic Syndrome |
| title_full_unstemmed | Growth Differentiation Factor-15: One of the Missing Links between Psoriasis and Metabolic Syndrome |
| title_short | Growth Differentiation Factor-15: One of the Missing Links between Psoriasis and Metabolic Syndrome |
| title_sort | growth differentiation factor 15 one of the missing links between psoriasis and metabolic syndrome |
| topic | growth differentiation factor-15 metabolic syndrome psoriasis |
| url | https://journals.lww.com/10.4103/idoj.idoj_546_24 |
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