Genomic and phenotypic stability of fusion-driven pediatric sarcoma cell lines

Genomic and phenotypic stability of fusion-driven pediatric sarcoma cell lines

Abstract Human cancer cell lines are the mainstay of cancer research. Recent reports showed that highly mutated adult carcinoma cell lines (mainly HeLa and MCF-7) present striking diversity across laboratories and that long-term continuous culturing results in genomic/transcriptomic heterogeneity wi...

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Main Authors: Merve Kasan, Florian H. Geyer, Jana Siebenlist, Martin Sill, Rupert Öllinger, Tobias Faehling, Enrique de Álava, Didier Surdez, Uta Dirksen, Ina Oehme, Katia Scotlandi, Olivier Delattre, Martina Müller-Nurasyid, Roland Rad, Konstantin Strauch, Thomas G. P. Grünewald, Florencia Cidre-Aranaz
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55340-5
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