Toxin-mediated gene regulatory mechanism in Staphylococcus aureus
The dangerous human pathogen Staphylococcus aureus relies heavily on toxins to cause disease, but toxin production can put a strong burden on the bacteria’s energy balance. Thus, controlling the synthesis of proteins solely needed in times of toxin production represents a way for the bacteria to avo...
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| Language: | English |
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Shared Science Publishers OG
2016-12-01
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| Series: | Microbial Cell |
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| Online Access: | http://microbialcell.com/researcharticles/toxin-mediated-gene-regulatory-mechanism-in-staphylococcus-aureus/ |
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| author | Hwang-Soo Joo Michael Otto |
| author_facet | Hwang-Soo Joo Michael Otto |
| author_sort | Hwang-Soo Joo |
| collection | DOAJ |
| description | The dangerous human pathogen Staphylococcus aureus relies heavily on toxins to cause disease, but toxin production can put a strong burden on the bacteria’s energy balance. Thus, controlling the synthesis of proteins solely needed in times of toxin production represents a way for the bacteria to avoid wasting energy. One hypothetical manner to accomplish this sort of regulation is by gene regulatory functions of the toxins themselves. There have been several reports about gene regulation by toxins in S. aureus, but these were never verified on the molecular level. In our study published in MBio [Joo et al., 7(5). pii: e01579-16], we show that phenol-soluble modulins (PSMs), important peptide toxins of S. aureus, release a repressor from the promoter of the operon encoding the toxin export system, thereby enabling toxin secretion. This study describes the first molecular regulatory mechanism exerted by an S. aureus toxin, setting a paradigmatic example of how S. aureus toxins may influence cell functions to adjust them to times of toxin production. |
| format | Article |
| id | doaj-art-4979ea96f9554279a56ba73fd8f86dab |
| institution | OA Journals |
| issn | 2311-2638 |
| language | English |
| publishDate | 2016-12-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj-art-4979ea96f9554279a56ba73fd8f86dab2025-08-20T02:05:20ZengShared Science Publishers OGMicrobial Cell2311-26382016-12-0141293110.15698/mic2017.01.553Toxin-mediated gene regulatory mechanism in Staphylococcus aureusHwang-Soo Joo0Michael Otto1Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA.Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA.The dangerous human pathogen Staphylococcus aureus relies heavily on toxins to cause disease, but toxin production can put a strong burden on the bacteria’s energy balance. Thus, controlling the synthesis of proteins solely needed in times of toxin production represents a way for the bacteria to avoid wasting energy. One hypothetical manner to accomplish this sort of regulation is by gene regulatory functions of the toxins themselves. There have been several reports about gene regulation by toxins in S. aureus, but these were never verified on the molecular level. In our study published in MBio [Joo et al., 7(5). pii: e01579-16], we show that phenol-soluble modulins (PSMs), important peptide toxins of S. aureus, release a repressor from the promoter of the operon encoding the toxin export system, thereby enabling toxin secretion. This study describes the first molecular regulatory mechanism exerted by an S. aureus toxin, setting a paradigmatic example of how S. aureus toxins may influence cell functions to adjust them to times of toxin production.http://microbialcell.com/researcharticles/toxin-mediated-gene-regulatory-mechanism-in-staphylococcus-aureus/Staphylococcus aureusphenol-soluble modulinstoxingene regulationGntRYtrA |
| spellingShingle | Hwang-Soo Joo Michael Otto Toxin-mediated gene regulatory mechanism in Staphylococcus aureus Microbial Cell Staphylococcus aureus phenol-soluble modulins toxin gene regulation GntR YtrA |
| title | Toxin-mediated gene regulatory mechanism in Staphylococcus aureus |
| title_full | Toxin-mediated gene regulatory mechanism in Staphylococcus aureus |
| title_fullStr | Toxin-mediated gene regulatory mechanism in Staphylococcus aureus |
| title_full_unstemmed | Toxin-mediated gene regulatory mechanism in Staphylococcus aureus |
| title_short | Toxin-mediated gene regulatory mechanism in Staphylococcus aureus |
| title_sort | toxin mediated gene regulatory mechanism in staphylococcus aureus |
| topic | Staphylococcus aureus phenol-soluble modulins toxin gene regulation GntR YtrA |
| url | http://microbialcell.com/researcharticles/toxin-mediated-gene-regulatory-mechanism-in-staphylococcus-aureus/ |
| work_keys_str_mv | AT hwangsoojoo toxinmediatedgeneregulatorymechanisminstaphylococcusaureus AT michaelotto toxinmediatedgeneregulatorymechanisminstaphylococcusaureus |