Alterations on Microcirculation of Optic Nerve Head Before and After OSA Surgery
Pei-Wen Lin,1– 4,* Li-Wen Chiu,1 Chung-Wei Lin,5 Chun-Tuan Chang,6 Hsin-Ching Lin2– 8,* 1Division of Glaucoma, Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan; 2Sleep Center, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan; 3Co...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2025-06-01
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| Series: | Nature and Science of Sleep |
| Subjects: | |
| Online Access: | https://www.dovepress.com/alterations-on-microcirculation-of-optic-nerve-head-before-and-after-o-peer-reviewed-fulltext-article-NSS |
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| Summary: | Pei-Wen Lin,1– 4,* Li-Wen Chiu,1 Chung-Wei Lin,5 Chun-Tuan Chang,6 Hsin-Ching Lin2– 8,* 1Division of Glaucoma, Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan; 2Sleep Center, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan; 3College of Medicine, Chang Gung University, Taoyuan, Taiwan; 4College of Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan; 5Department of Otolaryngology and Robotic Surgery Center, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan; 6Department of Business Management, Institute of Healthcare Management, National Sun Yat-sen University, Kaohsiung, Taiwan; 7Department of Otolaryngology and Robotic Surgery Center, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan; 8Institute of Biomedical Science, National Sun Yat-sen University, Kaohsiung, Taiwan*These authors contributed equally to this workCorrespondence: Hsin-Ching Lin, Department of Otolaryngology, Kaohsiung Municipal Ta-Tung Hospital and Kaohsiung Chang Gung Memorial Hospital, 123, Ta-Pei Road, Niao-Sung District, Kaohsiung, 833, Taiwan, Tel +886-7-7317123 ext. 2533, Fax +886-7-7313855, Email hclin@adm.cgmh.org.tw; enthclin@aol.comObjective: Obstructive sleep apnea/hypopnea syndrome (OSA) can compromise oxygenation of the optic nerve and cause glaucomatous optic neuropathy; however, there were no studies to investigate the changes of optic nerve microcirculation in patients with OSA before and after treatment. We conducted the first study to assess whether OSA surgery will change the optic nerve microcirculation in patients with OSA.Study Design: Prospective single-blind study.Setting: Tertiary medical center.Methods: The enrolled patients were completed for overnight polysomnography (PSG) and comprehensive ophthalmologic evaluation, including laser speckle flowgraphy (LSFG) for microcirculation of optic nerve head (ONH) before and 3 months after OSA surgery. LSFG measurements were summarized as mean blur rate in all areas (MA), in big vessel area (MV) and in tissue area (MT) of ONH.Results: Twenty-nine patients underwent upper airway surgery were included. Three months after surgery, 75.9% (22/29) patients, including 15 of 20 patients with severe OSA and 7 of 9 patients with moderate OSA had improvement in apnea/hypopnea index (AHI). The major parameters of PSG significantly improved. Regarding the LSFG parameters, MA (p = 0.023), MV (p = 0.033) and MT (p = 0.026) significantly increased 3 months after surgery. Moreover, there were significant differences in MA (p = 0.035) and MT (p = 0.045) in the AHI-improved subgroup after surgery.Conclusion: The ONH microcirculation significantly improved in the AHI-improved patients with OSA 3 months after upper airway surgery. Upper airway surgery may ameliorate the ONH microcirculation in patients with OSA.Keywords: snoring, obstructive sleep apnea syndrome, obstructive sleep apnea surgery, laser speckle flowgraphy, optic nerve head microcirculation |
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| ISSN: | 1179-1608 |