Synthesis, Characterization, and Biological Activity of Novel Schiff and Mannich Bases of 4-Amino-3-(N-phthalimidomethyl)-1,2,4-triazole-5-thione
The present work describes the syntheses and antimicrobial activity studies of a series of novel Schiff bases (4a–4i) and their Mannich bases (5a–5h) starting from 4-amino-3-(N-phthalimido-methyl)-1,2,4-triazole-5-thione (3). All the synthesized compounds were characterized by IR, 1H-NMR, 13C-NMR, a...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/638520 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849404902694977536 |
|---|---|
| author | Uzma Yunus Moazzam H. Bhatti Naima Rahman Nosheen Mussarat Shazia Asghar Bilal Masood |
| author_facet | Uzma Yunus Moazzam H. Bhatti Naima Rahman Nosheen Mussarat Shazia Asghar Bilal Masood |
| author_sort | Uzma Yunus |
| collection | DOAJ |
| description | The present work describes the syntheses and antimicrobial activity studies of a series of novel Schiff bases (4a–4i) and their Mannich bases (5a–5h) starting from 4-amino-3-(N-phthalimido-methyl)-1,2,4-triazole-5-thione (3). All the synthesized compounds were characterized by IR, 1H-NMR, 13C-NMR, and MS. All the synthesized compounds were screened for four Gram-negative strains, one Gram-positive strain of bacteria, and one diploid fungal strain. In general the antimicrobial activity increased remarkably on the introduction of azomethine functionality in parent triazole (3). The antimicrobial activity further improved when morpholine group was added to them except for Enterobacter cloacae, where loss of activity was observed. The results are promising and show that the fine tuning of the structures (5a, 5b, 5e, 5f, and 5h) can lead to some new antimicrobial compounds. |
| format | Article |
| id | doaj-art-496dd4ebe0794feea0b7c90cb0c4f661 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-496dd4ebe0794feea0b7c90cb0c4f6612025-08-20T03:36:48ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/638520638520Synthesis, Characterization, and Biological Activity of Novel Schiff and Mannich Bases of 4-Amino-3-(N-phthalimidomethyl)-1,2,4-triazole-5-thioneUzma Yunus0Moazzam H. Bhatti1Naima Rahman2Nosheen Mussarat3Shazia Asghar4Bilal Masood5Department of Chemistry, Allama Iqbal Open University, Islamabad 44000, PakistanDepartment of Chemistry, Allama Iqbal Open University, Islamabad 44000, PakistanDepartment of Chemistry, Allama Iqbal Open University, Islamabad 44000, PakistanDepartment of Chemistry, Allama Iqbal Open University, Islamabad 44000, PakistanDepartment of Chemistry, Allama Iqbal Open University, Islamabad 44000, PakistanDepartment of Chemistry, Allama Iqbal Open University, Islamabad 44000, PakistanThe present work describes the syntheses and antimicrobial activity studies of a series of novel Schiff bases (4a–4i) and their Mannich bases (5a–5h) starting from 4-amino-3-(N-phthalimido-methyl)-1,2,4-triazole-5-thione (3). All the synthesized compounds were characterized by IR, 1H-NMR, 13C-NMR, and MS. All the synthesized compounds were screened for four Gram-negative strains, one Gram-positive strain of bacteria, and one diploid fungal strain. In general the antimicrobial activity increased remarkably on the introduction of azomethine functionality in parent triazole (3). The antimicrobial activity further improved when morpholine group was added to them except for Enterobacter cloacae, where loss of activity was observed. The results are promising and show that the fine tuning of the structures (5a, 5b, 5e, 5f, and 5h) can lead to some new antimicrobial compounds.http://dx.doi.org/10.1155/2013/638520 |
| spellingShingle | Uzma Yunus Moazzam H. Bhatti Naima Rahman Nosheen Mussarat Shazia Asghar Bilal Masood Synthesis, Characterization, and Biological Activity of Novel Schiff and Mannich Bases of 4-Amino-3-(N-phthalimidomethyl)-1,2,4-triazole-5-thione Journal of Chemistry |
| title | Synthesis, Characterization, and Biological Activity of Novel Schiff and Mannich Bases of 4-Amino-3-(N-phthalimidomethyl)-1,2,4-triazole-5-thione |
| title_full | Synthesis, Characterization, and Biological Activity of Novel Schiff and Mannich Bases of 4-Amino-3-(N-phthalimidomethyl)-1,2,4-triazole-5-thione |
| title_fullStr | Synthesis, Characterization, and Biological Activity of Novel Schiff and Mannich Bases of 4-Amino-3-(N-phthalimidomethyl)-1,2,4-triazole-5-thione |
| title_full_unstemmed | Synthesis, Characterization, and Biological Activity of Novel Schiff and Mannich Bases of 4-Amino-3-(N-phthalimidomethyl)-1,2,4-triazole-5-thione |
| title_short | Synthesis, Characterization, and Biological Activity of Novel Schiff and Mannich Bases of 4-Amino-3-(N-phthalimidomethyl)-1,2,4-triazole-5-thione |
| title_sort | synthesis characterization and biological activity of novel schiff and mannich bases of 4 amino 3 n phthalimidomethyl 1 2 4 triazole 5 thione |
| url | http://dx.doi.org/10.1155/2013/638520 |
| work_keys_str_mv | AT uzmayunus synthesischaracterizationandbiologicalactivityofnovelschiffandmannichbasesof4amino3nphthalimidomethyl124triazole5thione AT moazzamhbhatti synthesischaracterizationandbiologicalactivityofnovelschiffandmannichbasesof4amino3nphthalimidomethyl124triazole5thione AT naimarahman synthesischaracterizationandbiologicalactivityofnovelschiffandmannichbasesof4amino3nphthalimidomethyl124triazole5thione AT nosheenmussarat synthesischaracterizationandbiologicalactivityofnovelschiffandmannichbasesof4amino3nphthalimidomethyl124triazole5thione AT shaziaasghar synthesischaracterizationandbiologicalactivityofnovelschiffandmannichbasesof4amino3nphthalimidomethyl124triazole5thione AT bilalmasood synthesischaracterizationandbiologicalactivityofnovelschiffandmannichbasesof4amino3nphthalimidomethyl124triazole5thione |