Microscopic messengers: Extracellular vesicles shaping gastrointestinal health and disease
Abstract The field of extracellular vesicles (EVs) is advancing rapidly, and this review aims to synthesize the latest research connected to EVs and the gastrointestinal tract. We will address new and emerging roles for EVs derived from internal sources such as the pancreas and immune system and how...
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| Format: | Article |
| Language: | English |
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Wiley
2025-04-01
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| Series: | Physiological Reports |
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| Online Access: | https://doi.org/10.14814/phy2.70292 |
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| author | Zhantao Yu Kevin A. Swift Madeline A. Hedges Arianne L. Theiss Sarah F. Andres |
| author_facet | Zhantao Yu Kevin A. Swift Madeline A. Hedges Arianne L. Theiss Sarah F. Andres |
| author_sort | Zhantao Yu |
| collection | DOAJ |
| description | Abstract The field of extracellular vesicles (EVs) is advancing rapidly, and this review aims to synthesize the latest research connected to EVs and the gastrointestinal tract. We will address new and emerging roles for EVs derived from internal sources such as the pancreas and immune system and how these miniature messengers alter organismal health or the inflammatory response within the GI tract. We will examine what is known about external EVs from dietary and bacterial sources and the immense anti‐inflammatory, immune‐modulatory, and proliferative potential within these nano‐sized information carriers. EV interactions with the intestinal and colonic epithelium and associated immune cells at homeostatic and disease states, such as necrotizing enterocolitis (NEC) and inflammatory bowel disease (IBD) will also be covered. We will discuss how EVs are being leveraged as therapeutics or for drug delivery and conclude with a series of unanswered questions in the field. |
| format | Article |
| id | doaj-art-496a647c9ffc427bb4630a822a50aa1a |
| institution | DOAJ |
| issn | 2051-817X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj-art-496a647c9ffc427bb4630a822a50aa1a2025-08-20T03:10:39ZengWileyPhysiological Reports2051-817X2025-04-01137n/an/a10.14814/phy2.70292Microscopic messengers: Extracellular vesicles shaping gastrointestinal health and diseaseZhantao Yu0Kevin A. Swift1Madeline A. Hedges2Arianne L. Theiss3Sarah F. Andres4Division of Gastroenterology and Hepatology, Department of Medicine and the Mucosal Inflammation Program University of Colorado School of Medicine Aurora Colorado USADepartment of Pediatrics, Pediatric GI Division, School of Medicine Oregon Health and Science University Portland Oregon USADepartment of Neonatology, School of Medicine Oregon Health and Science University Portland Oregon USADivision of Gastroenterology and Hepatology, Department of Medicine and the Mucosal Inflammation Program University of Colorado School of Medicine Aurora Colorado USADepartment of Pediatrics, Pediatric GI Division, School of Medicine Oregon Health and Science University Portland Oregon USAAbstract The field of extracellular vesicles (EVs) is advancing rapidly, and this review aims to synthesize the latest research connected to EVs and the gastrointestinal tract. We will address new and emerging roles for EVs derived from internal sources such as the pancreas and immune system and how these miniature messengers alter organismal health or the inflammatory response within the GI tract. We will examine what is known about external EVs from dietary and bacterial sources and the immense anti‐inflammatory, immune‐modulatory, and proliferative potential within these nano‐sized information carriers. EV interactions with the intestinal and colonic epithelium and associated immune cells at homeostatic and disease states, such as necrotizing enterocolitis (NEC) and inflammatory bowel disease (IBD) will also be covered. We will discuss how EVs are being leveraged as therapeutics or for drug delivery and conclude with a series of unanswered questions in the field.https://doi.org/10.14814/phy2.70292bacteriaexosomeinflammationintestine |
| spellingShingle | Zhantao Yu Kevin A. Swift Madeline A. Hedges Arianne L. Theiss Sarah F. Andres Microscopic messengers: Extracellular vesicles shaping gastrointestinal health and disease Physiological Reports bacteria exosome inflammation intestine |
| title | Microscopic messengers: Extracellular vesicles shaping gastrointestinal health and disease |
| title_full | Microscopic messengers: Extracellular vesicles shaping gastrointestinal health and disease |
| title_fullStr | Microscopic messengers: Extracellular vesicles shaping gastrointestinal health and disease |
| title_full_unstemmed | Microscopic messengers: Extracellular vesicles shaping gastrointestinal health and disease |
| title_short | Microscopic messengers: Extracellular vesicles shaping gastrointestinal health and disease |
| title_sort | microscopic messengers extracellular vesicles shaping gastrointestinal health and disease |
| topic | bacteria exosome inflammation intestine |
| url | https://doi.org/10.14814/phy2.70292 |
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