Verbascoside attenuates myocardial ischemia/reperfusion-induced ferroptosis following heterotopic heart transplantation via modulating GDF15/GPX4/SLC7A11 pathway

Verbascoside attenuates myocardial ischemia/reperfusion-induced ferroptosis following heterotopic heart transplantation via modulating GDF15/GPX4/SLC7A11 pathway

Abstract Myocardial cold ischemia/reperfusion (I/R) injury is an inevitable consequence of heart transplantation, significantly affecting survival rates and therapeutic outcomes. Growth Differentiation Factor 15 (GDF15) has been shown to regulate GPX4-mediated ferroptosis, playing a critical role in...

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Bibliographic Details
Main Authors: Yuxi Zhang, Junbiao Zhan, Zhen Qiu, Hao Tian, Shaoqing Lei, Qin Huang, Rui Xue, Qian Sun, Zhongyuan Xia
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Verbascoside
Heart transplantation
Myocardial cold ischemia /reperfusion injury
Ferroptosis
GDF15
Online Access:https://doi.org/10.1038/s41598-025-00112-4
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https://doi.org/10.1038/s41598-025-00112-4

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