De Novo CD5 Negative Blastic Mantle Cell Lymphoma Presented with Massive Bone Marrow Necrosis without Adenopathy or Organomegaly
The recent World Health Organization (WHO) classification defines mantle cell lymphoma (MCL) as a distinct entity characterized by a unique immunophenotype and a molecular hallmark of chromosomal translocation t(11;14)(q13;q32). We report an unusual case of an advanced stage of CD5 negative MCL wit...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2015/146598 |
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| author | Ghaleb Elyamany Ali Matar Alzahrani Eman Al Mussaed Hassan Aljasem Sultan Alotaibi Hatem Elghezal |
| author_facet | Ghaleb Elyamany Ali Matar Alzahrani Eman Al Mussaed Hassan Aljasem Sultan Alotaibi Hatem Elghezal |
| author_sort | Ghaleb Elyamany |
| collection | DOAJ |
| description | The recent World Health Organization (WHO) classification defines mantle cell lymphoma (MCL) as a distinct entity characterized by a unique immunophenotype and a molecular hallmark of chromosomal translocation t(11;14)(q13;q32). We report an unusual case of an advanced stage of CD5 negative MCL with a blastoid variant with a massive bone marrow (BM) necrosis as an initial presenting feature, with no adenopathy or hepatosplenomegaly. The pathologic features showed blastoid variant of MCL and flow cytometry showed that the tumor cells were CD5−, CD19+, CD20+, FMC-7+, CD23−, and lambda light chain restricted. Chromosomal analysis, using karyotype and fluorescent in situ hybridization (FISH), demonstrated karyotypic abnormalities in addition to the t(11;14). Our case study may be reported as a unique case of CD5− blastic MCL with unusual presentation and findings which made the diagnosis of MCL difficult. |
| format | Article |
| id | doaj-art-49634086d3bf45a0ba091ed5ea0e105b |
| institution | OA Journals |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-49634086d3bf45a0ba091ed5ea0e105b2025-08-20T02:05:56ZengWileyCase Reports in Hematology2090-65602090-65792015-01-01201510.1155/2015/146598146598De Novo CD5 Negative Blastic Mantle Cell Lymphoma Presented with Massive Bone Marrow Necrosis without Adenopathy or OrganomegalyGhaleb Elyamany0Ali Matar Alzahrani1Eman Al Mussaed2Hassan Aljasem3Sultan Alotaibi4Hatem Elghezal5Department of Central Military Laboratory and Blood Bank, Prince Sultan Military Medical City, P.O. Box 7897, Riyadh 11159, Saudi ArabiaDepartment of Oncology, Prince Sultan Military Medical City, P.O. Box 7897, Riyadh 11159, Saudi ArabiaDepartment of Basic Science, Princess Nourah Bint Abdulrahman University, College of Medicine, Riyadh, Saudi ArabiaDepartment of Adult Clinical Hematology and Stem Cell Therapy, Prince Sultan Military Medical City, P.O. Box 7897, Riyadh 11159, Saudi ArabiaDepartment of Adult Clinical Hematology and Stem Cell Therapy, Prince Sultan Military Medical City, P.O. Box 7897, Riyadh 11159, Saudi ArabiaDepartment of Central Military Laboratory and Blood Bank, Prince Sultan Military Medical City, P.O. Box 7897, Riyadh 11159, Saudi ArabiaThe recent World Health Organization (WHO) classification defines mantle cell lymphoma (MCL) as a distinct entity characterized by a unique immunophenotype and a molecular hallmark of chromosomal translocation t(11;14)(q13;q32). We report an unusual case of an advanced stage of CD5 negative MCL with a blastoid variant with a massive bone marrow (BM) necrosis as an initial presenting feature, with no adenopathy or hepatosplenomegaly. The pathologic features showed blastoid variant of MCL and flow cytometry showed that the tumor cells were CD5−, CD19+, CD20+, FMC-7+, CD23−, and lambda light chain restricted. Chromosomal analysis, using karyotype and fluorescent in situ hybridization (FISH), demonstrated karyotypic abnormalities in addition to the t(11;14). Our case study may be reported as a unique case of CD5− blastic MCL with unusual presentation and findings which made the diagnosis of MCL difficult.http://dx.doi.org/10.1155/2015/146598 |
| spellingShingle | Ghaleb Elyamany Ali Matar Alzahrani Eman Al Mussaed Hassan Aljasem Sultan Alotaibi Hatem Elghezal De Novo CD5 Negative Blastic Mantle Cell Lymphoma Presented with Massive Bone Marrow Necrosis without Adenopathy or Organomegaly Case Reports in Hematology |
| title | De Novo CD5 Negative Blastic Mantle Cell Lymphoma Presented with Massive Bone Marrow Necrosis without Adenopathy or Organomegaly |
| title_full | De Novo CD5 Negative Blastic Mantle Cell Lymphoma Presented with Massive Bone Marrow Necrosis without Adenopathy or Organomegaly |
| title_fullStr | De Novo CD5 Negative Blastic Mantle Cell Lymphoma Presented with Massive Bone Marrow Necrosis without Adenopathy or Organomegaly |
| title_full_unstemmed | De Novo CD5 Negative Blastic Mantle Cell Lymphoma Presented with Massive Bone Marrow Necrosis without Adenopathy or Organomegaly |
| title_short | De Novo CD5 Negative Blastic Mantle Cell Lymphoma Presented with Massive Bone Marrow Necrosis without Adenopathy or Organomegaly |
| title_sort | de novo cd5 negative blastic mantle cell lymphoma presented with massive bone marrow necrosis without adenopathy or organomegaly |
| url | http://dx.doi.org/10.1155/2015/146598 |
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