Matrix Metalloproteinases in Glioma: Drivers of Invasion and Therapeutic Targets
Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteolytic enzymes that are crucial for the remodeling of the extracellular matrix, a process that is often co-opted by cancers, including brain tumors, to facilitate growth, invasion, and metastasis. In gliomas, MMPs contribute to a c...
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MDPI AG
2025-04-01
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| author | Ella E. Aitchison Alexandra M. Dimesa Alireza Shoari |
| author_facet | Ella E. Aitchison Alexandra M. Dimesa Alireza Shoari |
| author_sort | Ella E. Aitchison |
| collection | DOAJ |
| description | Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteolytic enzymes that are crucial for the remodeling of the extracellular matrix, a process that is often co-opted by cancers, including brain tumors, to facilitate growth, invasion, and metastasis. In gliomas, MMPs contribute to a complex interplay involving tumor proliferation, angiogenesis, and immune modulation, thereby influencing tumor progression and patient prognosis. This review provides a comprehensive analysis of the roles of various MMPs in different types of gliomas, from highly malignant gliomas to metastatic lesions. Emphasis is placed on how the dysregulation of MMPs impacts tumor behavior, the association between specific MMPs and the tumor grade, and their potential as biomarkers for diagnosis and prognosis. Additionally, the current therapeutic approaches targeting MMP activity are discussed, exploring both their challenges and future potential. By synthesizing recent findings, this paper aims to clarify the broad significance of MMPs in gliomas and propose avenues for translational research that could enhance treatment strategies and clinical outcomes. |
| format | Article |
| id | doaj-art-49602fb089ab43a0bca0ce826b8f8c02 |
| institution | Kabale University |
| issn | 2673-6284 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | BioTech |
| spelling | doaj-art-49602fb089ab43a0bca0ce826b8f8c022025-08-20T03:27:13ZengMDPI AGBioTech2673-62842025-04-011422810.3390/biotech14020028Matrix Metalloproteinases in Glioma: Drivers of Invasion and Therapeutic TargetsElla E. Aitchison0Alexandra M. Dimesa1Alireza Shoari2Department of Cancer Biology, Mayo Clinic, Jacksonville, FL 32224, USADepartment of Cancer Biology, Mayo Clinic, Jacksonville, FL 32224, USADepartment of Cancer Biology, Mayo Clinic, Jacksonville, FL 32224, USAMatrix metalloproteinases (MMPs) are a family of zinc-dependent proteolytic enzymes that are crucial for the remodeling of the extracellular matrix, a process that is often co-opted by cancers, including brain tumors, to facilitate growth, invasion, and metastasis. In gliomas, MMPs contribute to a complex interplay involving tumor proliferation, angiogenesis, and immune modulation, thereby influencing tumor progression and patient prognosis. This review provides a comprehensive analysis of the roles of various MMPs in different types of gliomas, from highly malignant gliomas to metastatic lesions. Emphasis is placed on how the dysregulation of MMPs impacts tumor behavior, the association between specific MMPs and the tumor grade, and their potential as biomarkers for diagnosis and prognosis. Additionally, the current therapeutic approaches targeting MMP activity are discussed, exploring both their challenges and future potential. By synthesizing recent findings, this paper aims to clarify the broad significance of MMPs in gliomas and propose avenues for translational research that could enhance treatment strategies and clinical outcomes.https://www.mdpi.com/2673-6284/14/2/28matrix metalloproteinases (MMPs)gliomasglioblastomatumor invasiontherapeutic targeting |
| spellingShingle | Ella E. Aitchison Alexandra M. Dimesa Alireza Shoari Matrix Metalloproteinases in Glioma: Drivers of Invasion and Therapeutic Targets BioTech matrix metalloproteinases (MMPs) gliomas glioblastoma tumor invasion therapeutic targeting |
| title | Matrix Metalloproteinases in Glioma: Drivers of Invasion and Therapeutic Targets |
| title_full | Matrix Metalloproteinases in Glioma: Drivers of Invasion and Therapeutic Targets |
| title_fullStr | Matrix Metalloproteinases in Glioma: Drivers of Invasion and Therapeutic Targets |
| title_full_unstemmed | Matrix Metalloproteinases in Glioma: Drivers of Invasion and Therapeutic Targets |
| title_short | Matrix Metalloproteinases in Glioma: Drivers of Invasion and Therapeutic Targets |
| title_sort | matrix metalloproteinases in glioma drivers of invasion and therapeutic targets |
| topic | matrix metalloproteinases (MMPs) gliomas glioblastoma tumor invasion therapeutic targeting |
| url | https://www.mdpi.com/2673-6284/14/2/28 |
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