Triglyceride–glucose index: a potent predictor of metabolic risk factors and eating behavior patterns among obese individuals
Abstract Background The strong potential of triglyceride to glucose index (TyG) in prediction of metabolic abnormalities is well identified in numerous disease including diabetes, metabolic syndrome and kidney disorders. However, no study is available to assess its validity and association with meta...
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BMC
2025-03-01
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| Series: | BMC Endocrine Disorders |
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| Online Access: | https://doi.org/10.1186/s12902-025-01887-3 |
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| author | Amr Ali Mohamed Abdelgawwad El-Sehrawy Lusine G. Khachatryan Aziz Kubaev M. M. Rekha Safia Obaidur Rab Mandeep Kaur Manmeet Singh Manish Srivastava Abed J. Kadhim Ahmed Hussein Zwamel |
| author_facet | Amr Ali Mohamed Abdelgawwad El-Sehrawy Lusine G. Khachatryan Aziz Kubaev M. M. Rekha Safia Obaidur Rab Mandeep Kaur Manmeet Singh Manish Srivastava Abed J. Kadhim Ahmed Hussein Zwamel |
| author_sort | Amr Ali Mohamed Abdelgawwad El-Sehrawy |
| collection | DOAJ |
| description | Abstract Background The strong potential of triglyceride to glucose index (TyG) in prediction of metabolic abnormalities is well identified in numerous disease including diabetes, metabolic syndrome and kidney disorders. However, no study is available to assess its validity and association with metabolic phenotype among obese individuals. In the current study, we aimed to evaluate the TyG index, its validity and association with metabolic parameters among obese individuals. Methods and materials : In the current cross-sectional study, 300 obese individuals were enrolled. Their demographic, anthropometric measurements were done and laboratory parameters including serum lipids, glycemic markers and insulin resistance were evaluated. Blood pressure was also measured with standard methods. The TyG index was calculated as the ln (fasting triglyceride level [mg/dL] × fasting glucose level [mg/dL]/2). Eating pattern was measured with three factor eating behavior questionnaire (TFEQ). Receiver operator characteristic curve was used to assess the TyG validity. Results Subjects at the higher TyG tertile had higher waist o hip ratio (WHR) and eating disorder compared with lowest tertiles. Also, those at the highest tertiles had significantly higher total cholesterol (TC), triglyceride (TG), and fasting blood sugar (FBS), and lower high density lipoprotein cholesterol (HDL). According to the ROC curve analysis for various metabolic parameters, TyG demonstrated the highest area under curve (AUC) value of 0.838 compared with other metabolic parameters in identification of metabolic syndrome. Conclusion The current study provides valuable insights into the relationship between TyG index, metabolic parameters, and eating behaviors among obese individuals. |
| format | Article |
| id | doaj-art-495d7cc3db5c452f911048199fca0aae |
| institution | DOAJ |
| issn | 1472-6823 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj-art-495d7cc3db5c452f911048199fca0aae2025-08-20T02:41:32ZengBMCBMC Endocrine Disorders1472-68232025-03-0125111010.1186/s12902-025-01887-3Triglyceride–glucose index: a potent predictor of metabolic risk factors and eating behavior patterns among obese individualsAmr Ali Mohamed Abdelgawwad El-Sehrawy0Lusine G. Khachatryan1Aziz Kubaev2M. M. Rekha3Safia Obaidur Rab4Mandeep Kaur5Manmeet Singh6Manish Srivastava7Abed J. Kadhim8Ahmed Hussein Zwamel9Department of Internal Medicine, Diabetes, Endocrinology and Metabolism, Mansoura UniversityDepartment of Pediatric Diseases, N.F. Filatov Clinical Institute of Children’s Health, I.M. Sechenov First Moscow State Medical University (Sechenov University)Department of Maxillofacial Surgery, Samarkand State Medical UniversityDepartment of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University)Central Labs, King Khalid University, AlQura’aDepartment of Sciences, Vivekananda Global UniversityDepartment of Applied Sciences, Chandigarh Engineering College, Chandigarh Group of Colleges- JhanjeriDepartment of Endocrinology, National Institute of Medical Sciences, NIMS University RajasthanDepartment of Medical Engineering, Al-Nisour University CollegeMedical Laboratory Technique College, the Islamic UniversityAbstract Background The strong potential of triglyceride to glucose index (TyG) in prediction of metabolic abnormalities is well identified in numerous disease including diabetes, metabolic syndrome and kidney disorders. However, no study is available to assess its validity and association with metabolic phenotype among obese individuals. In the current study, we aimed to evaluate the TyG index, its validity and association with metabolic parameters among obese individuals. Methods and materials : In the current cross-sectional study, 300 obese individuals were enrolled. Their demographic, anthropometric measurements were done and laboratory parameters including serum lipids, glycemic markers and insulin resistance were evaluated. Blood pressure was also measured with standard methods. The TyG index was calculated as the ln (fasting triglyceride level [mg/dL] × fasting glucose level [mg/dL]/2). Eating pattern was measured with three factor eating behavior questionnaire (TFEQ). Receiver operator characteristic curve was used to assess the TyG validity. Results Subjects at the higher TyG tertile had higher waist o hip ratio (WHR) and eating disorder compared with lowest tertiles. Also, those at the highest tertiles had significantly higher total cholesterol (TC), triglyceride (TG), and fasting blood sugar (FBS), and lower high density lipoprotein cholesterol (HDL). According to the ROC curve analysis for various metabolic parameters, TyG demonstrated the highest area under curve (AUC) value of 0.838 compared with other metabolic parameters in identification of metabolic syndrome. Conclusion The current study provides valuable insights into the relationship between TyG index, metabolic parameters, and eating behaviors among obese individuals.https://doi.org/10.1186/s12902-025-01887-3ObesityTriglyceride to glucose indexTyGMetabolic syndromeLipid profile |
| spellingShingle | Amr Ali Mohamed Abdelgawwad El-Sehrawy Lusine G. Khachatryan Aziz Kubaev M. M. Rekha Safia Obaidur Rab Mandeep Kaur Manmeet Singh Manish Srivastava Abed J. Kadhim Ahmed Hussein Zwamel Triglyceride–glucose index: a potent predictor of metabolic risk factors and eating behavior patterns among obese individuals BMC Endocrine Disorders Obesity Triglyceride to glucose index TyG Metabolic syndrome Lipid profile |
| title | Triglyceride–glucose index: a potent predictor of metabolic risk factors and eating behavior patterns among obese individuals |
| title_full | Triglyceride–glucose index: a potent predictor of metabolic risk factors and eating behavior patterns among obese individuals |
| title_fullStr | Triglyceride–glucose index: a potent predictor of metabolic risk factors and eating behavior patterns among obese individuals |
| title_full_unstemmed | Triglyceride–glucose index: a potent predictor of metabolic risk factors and eating behavior patterns among obese individuals |
| title_short | Triglyceride–glucose index: a potent predictor of metabolic risk factors and eating behavior patterns among obese individuals |
| title_sort | triglyceride glucose index a potent predictor of metabolic risk factors and eating behavior patterns among obese individuals |
| topic | Obesity Triglyceride to glucose index TyG Metabolic syndrome Lipid profile |
| url | https://doi.org/10.1186/s12902-025-01887-3 |
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