AURKB and PI3K/AKT/mTOR pathways converge to regulate TERT expression

AURKB and PI3K/AKT/mTOR pathways converge to regulate TERT expression

Summary: Telomere length maintenance, critical for cancer progression, can be driven by TERT promoter mutations (TERTpMUT), which are markers of poor prognosis across multiple cancers. Their tumor-specificity also makes them attractive chemotherapeutic targets. Here, we identified previously unchara...

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Main Authors: Grace Lim, Althea Bastian, Saskia Fung, Farhana Mollah, Minh H. Nguyen, Adwoa A. Sey, Marthe Cheade, Rozelle Harvie, Nisha R. Singh, Sergey Kurdyukov, Kristie-Ann Dickson, Eugene H.Y. Choi, Ailise C. Seery, Matti L. Gild, Deborah J. Marsh, Hilda A. Pickett, Roger R. Reddel, Martyn Bullock, Roderick J. Clifton-Bligh
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:iScience
Subjects:
Oncology
Molecular biology
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225014555
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http://www.sciencedirect.com/science/article/pii/S2589004225014555

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