Alveolar Proteinosis in COVID-19: Clinical Case
Pulmonary alveolar proteinosis (PAP) is a rare, diffuse lung disease characterized by accumulation of lipoprotein in lung surfactant in the alveolar space and terminal bronchioles, leading to impaired gas exchange and arterial hypoxemia. We present the case of a 51-year-old woman who was admitted wi...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Pulmonology |
| Online Access: | http://dx.doi.org/10.1155/2022/1842566 |
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| _version_ | 1832549024718127104 |
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| author | Silvia Martin Bote Maria Angeles Herrera Morueco Beatriz Arias Arcos Javier García Lopez Maria Belen Lopez-Muñiz Ballesteros |
| author_facet | Silvia Martin Bote Maria Angeles Herrera Morueco Beatriz Arias Arcos Javier García Lopez Maria Belen Lopez-Muñiz Ballesteros |
| author_sort | Silvia Martin Bote |
| collection | DOAJ |
| description | Pulmonary alveolar proteinosis (PAP) is a rare, diffuse lung disease characterized by accumulation of lipoprotein in lung surfactant in the alveolar space and terminal bronchioles, leading to impaired gas exchange and arterial hypoxemia. We present the case of a 51-year-old woman who was admitted with a diagnosis of severe SARS-CoV-2 pneumonia. Her condition did not improve with corticosteroids. A chest CT scan revealed ground-glass opacities in all lung lobes, with septal thickening. A differential diagnosis was proposed with other diseases. Bronchoscopy revealed milky bronchoalveolar lavage fluid, and staining with periodic acid–Schiff was positive, thus indicating PAP. Therefore, the patient underwent whole lung lavage, which led to clinical, radiological, and functional improvement. In the context of the COVID-19 pandemic, differential diagnosis ensures that appropriate attention is given to less prevalent entities such as PAP. |
| format | Article |
| id | doaj-art-4951fb243d4f4d63a0ecbc38e6b23607 |
| institution | Kabale University |
| issn | 2090-6854 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pulmonology |
| spelling | doaj-art-4951fb243d4f4d63a0ecbc38e6b236072025-02-03T06:12:26ZengWileyCase Reports in Pulmonology2090-68542022-01-01202210.1155/2022/1842566Alveolar Proteinosis in COVID-19: Clinical CaseSilvia Martin Bote0Maria Angeles Herrera Morueco1Beatriz Arias Arcos2Javier García Lopez3Maria Belen Lopez-Muñiz Ballesteros4Department of Respiratory MedicineDepartment of Internal MedicineDepartment of Respiratory MedicineDepartment of Respiratory MedicineDepartment of Respiratory MedicinePulmonary alveolar proteinosis (PAP) is a rare, diffuse lung disease characterized by accumulation of lipoprotein in lung surfactant in the alveolar space and terminal bronchioles, leading to impaired gas exchange and arterial hypoxemia. We present the case of a 51-year-old woman who was admitted with a diagnosis of severe SARS-CoV-2 pneumonia. Her condition did not improve with corticosteroids. A chest CT scan revealed ground-glass opacities in all lung lobes, with septal thickening. A differential diagnosis was proposed with other diseases. Bronchoscopy revealed milky bronchoalveolar lavage fluid, and staining with periodic acid–Schiff was positive, thus indicating PAP. Therefore, the patient underwent whole lung lavage, which led to clinical, radiological, and functional improvement. In the context of the COVID-19 pandemic, differential diagnosis ensures that appropriate attention is given to less prevalent entities such as PAP.http://dx.doi.org/10.1155/2022/1842566 |
| spellingShingle | Silvia Martin Bote Maria Angeles Herrera Morueco Beatriz Arias Arcos Javier García Lopez Maria Belen Lopez-Muñiz Ballesteros Alveolar Proteinosis in COVID-19: Clinical Case Case Reports in Pulmonology |
| title | Alveolar Proteinosis in COVID-19: Clinical Case |
| title_full | Alveolar Proteinosis in COVID-19: Clinical Case |
| title_fullStr | Alveolar Proteinosis in COVID-19: Clinical Case |
| title_full_unstemmed | Alveolar Proteinosis in COVID-19: Clinical Case |
| title_short | Alveolar Proteinosis in COVID-19: Clinical Case |
| title_sort | alveolar proteinosis in covid 19 clinical case |
| url | http://dx.doi.org/10.1155/2022/1842566 |
| work_keys_str_mv | AT silviamartinbote alveolarproteinosisincovid19clinicalcase AT mariaangelesherreramorueco alveolarproteinosisincovid19clinicalcase AT beatrizariasarcos alveolarproteinosisincovid19clinicalcase AT javiergarcialopez alveolarproteinosisincovid19clinicalcase AT mariabelenlopezmunizballesteros alveolarproteinosisincovid19clinicalcase |