Neutrophilic Bronchial Inflammation Correlates with Clinical and Functional Findings in Patients with Noncystic Fibrosis Bronchiectasis
Background. Neutrophilic bronchial inflammation is a main feature of bronchiectasis, but not much is known about its relationship with other disease features. Aim. To compare airway inflammatory markers with clinical and functional findings in subjects with stable noncystic fibrosis bronchiectasis (...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/642503 |
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| author | Federico L. Dente Marta Bilotta Maria Laura Bartoli Elena Bacci Silvana Cianchetti Manuela Latorre Laura Malagrinò Dario Nieri Maria Adelaide Roggi Barbara Vagaggini Pierluigi Paggiaro |
| author_facet | Federico L. Dente Marta Bilotta Maria Laura Bartoli Elena Bacci Silvana Cianchetti Manuela Latorre Laura Malagrinò Dario Nieri Maria Adelaide Roggi Barbara Vagaggini Pierluigi Paggiaro |
| author_sort | Federico L. Dente |
| collection | DOAJ |
| description | Background. Neutrophilic bronchial inflammation is a main feature of bronchiectasis, but not much is known about its relationship with other disease features. Aim. To compare airway inflammatory markers with clinical and functional findings in subjects with stable noncystic fibrosis bronchiectasis (NCFB). Methods. 152 NFCB patients (62.6 years; females: 57.2%) underwent clinical and functional cross-sectional evaluation, including microbiologic and inflammatory cell profile in sputum, and exhaled breath condensate malondialdehyde (EBC-MDA). NFCB severity was assessed using BSI and FACED criteria. Results. Sputum neutrophil percentages inversely correlated with FEV1 (P<0.0001; rho = −0.428), weakly with Leicester Cough Questionnaire score (P=0.068; rho = −0.58), and directly with duration of the disease (P=0.004; rho = 0.3) and BSI severity score (P=0.005; rho = 0.37), but not with FACED. Sputum neutrophilia was higher in colonized subjects, P. aeruginosa colonized subjects showing greater sputum neutrophilia and lower FEV1. Patients with ≥3 exacerbations in the last year showed a significantly greater EBC-MDA than the remaining patients. Conclusions. Sputum neutrophilic inflammation and biomarkers of oxidative stress in EBC can be considered good biomarkers of disease severity in NCFB patients, as confirmed by pulmonary function, disease duration, bacterial colonization, BSI score, and exacerbation rate. |
| format | Article |
| id | doaj-art-49480ecff2a346f298970ae1315381aa |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-49480ecff2a346f298970ae1315381aa2025-08-20T03:36:48ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/642503642503Neutrophilic Bronchial Inflammation Correlates with Clinical and Functional Findings in Patients with Noncystic Fibrosis BronchiectasisFederico L. Dente0Marta Bilotta1Maria Laura Bartoli2Elena Bacci3Silvana Cianchetti4Manuela Latorre5Laura Malagrinò6Dario Nieri7Maria Adelaide Roggi8Barbara Vagaggini9Pierluigi Paggiaro10Cardiothoracic and Vascular Department, University of Pisa, Via Paradisa 2, 56124 Pisa, ItalyCardiothoracic and Vascular Department, University of Pisa, Via Paradisa 2, 56124 Pisa, ItalyCardiothoracic and Vascular Department, University of Pisa, Via Paradisa 2, 56124 Pisa, ItalyCardiothoracic and Vascular Department, University of Pisa, Via Paradisa 2, 56124 Pisa, ItalyCardiothoracic and Vascular Department, University of Pisa, Via Paradisa 2, 56124 Pisa, ItalyCardiothoracic and Vascular Department, University of Pisa, Via Paradisa 2, 56124 Pisa, ItalyCardiothoracic and Vascular Department, University of Pisa, Via Paradisa 2, 56124 Pisa, ItalyCardiothoracic and Vascular Department, University of Pisa, Via Paradisa 2, 56124 Pisa, ItalyCardiothoracic and Vascular Department, University of Pisa, Via Paradisa 2, 56124 Pisa, ItalyCardiothoracic and Vascular Department, University of Pisa, Via Paradisa 2, 56124 Pisa, ItalyCardiothoracic and Vascular Department, University of Pisa, Via Paradisa 2, 56124 Pisa, ItalyBackground. Neutrophilic bronchial inflammation is a main feature of bronchiectasis, but not much is known about its relationship with other disease features. Aim. To compare airway inflammatory markers with clinical and functional findings in subjects with stable noncystic fibrosis bronchiectasis (NCFB). Methods. 152 NFCB patients (62.6 years; females: 57.2%) underwent clinical and functional cross-sectional evaluation, including microbiologic and inflammatory cell profile in sputum, and exhaled breath condensate malondialdehyde (EBC-MDA). NFCB severity was assessed using BSI and FACED criteria. Results. Sputum neutrophil percentages inversely correlated with FEV1 (P<0.0001; rho = −0.428), weakly with Leicester Cough Questionnaire score (P=0.068; rho = −0.58), and directly with duration of the disease (P=0.004; rho = 0.3) and BSI severity score (P=0.005; rho = 0.37), but not with FACED. Sputum neutrophilia was higher in colonized subjects, P. aeruginosa colonized subjects showing greater sputum neutrophilia and lower FEV1. Patients with ≥3 exacerbations in the last year showed a significantly greater EBC-MDA than the remaining patients. Conclusions. Sputum neutrophilic inflammation and biomarkers of oxidative stress in EBC can be considered good biomarkers of disease severity in NCFB patients, as confirmed by pulmonary function, disease duration, bacterial colonization, BSI score, and exacerbation rate.http://dx.doi.org/10.1155/2015/642503 |
| spellingShingle | Federico L. Dente Marta Bilotta Maria Laura Bartoli Elena Bacci Silvana Cianchetti Manuela Latorre Laura Malagrinò Dario Nieri Maria Adelaide Roggi Barbara Vagaggini Pierluigi Paggiaro Neutrophilic Bronchial Inflammation Correlates with Clinical and Functional Findings in Patients with Noncystic Fibrosis Bronchiectasis Mediators of Inflammation |
| title | Neutrophilic Bronchial Inflammation Correlates with Clinical and Functional Findings in Patients with Noncystic Fibrosis Bronchiectasis |
| title_full | Neutrophilic Bronchial Inflammation Correlates with Clinical and Functional Findings in Patients with Noncystic Fibrosis Bronchiectasis |
| title_fullStr | Neutrophilic Bronchial Inflammation Correlates with Clinical and Functional Findings in Patients with Noncystic Fibrosis Bronchiectasis |
| title_full_unstemmed | Neutrophilic Bronchial Inflammation Correlates with Clinical and Functional Findings in Patients with Noncystic Fibrosis Bronchiectasis |
| title_short | Neutrophilic Bronchial Inflammation Correlates with Clinical and Functional Findings in Patients with Noncystic Fibrosis Bronchiectasis |
| title_sort | neutrophilic bronchial inflammation correlates with clinical and functional findings in patients with noncystic fibrosis bronchiectasis |
| url | http://dx.doi.org/10.1155/2015/642503 |
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