The Role of MicroRNAs in Hyperlipidemia: From Pathogenesis to Therapeutical Application
Hyperlipidemia is a common metabolic disorder with high morbidity and mortality, which brings heavy burden on social. Understanding its pathogenesis and finding its potential therapeutic targets are the focus of current research in this field. In recent years, an increasing number of studies have pr...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2022/3101900 |
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| _version_ | 1849404997694914560 |
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| author | Yu Xiang Li Mao Mei-Ling Zuo Gui-Lin Song Li-Ming Tan Zhong-Bao Yang |
| author_facet | Yu Xiang Li Mao Mei-Ling Zuo Gui-Lin Song Li-Ming Tan Zhong-Bao Yang |
| author_sort | Yu Xiang |
| collection | DOAJ |
| description | Hyperlipidemia is a common metabolic disorder with high morbidity and mortality, which brings heavy burden on social. Understanding its pathogenesis and finding its potential therapeutic targets are the focus of current research in this field. In recent years, an increasing number of studies have proved that miRNAs play vital roles in regulating lipid metabolism and were considered as promising therapeutic targets for hyperlipidemia and related diseases. It is demonstrated that miR-191, miR-222, miR-224, miR-27a, miR-378a-3p, miR-140-5p, miR-483, and miR-520d-5p were closely associated with the pathogenesis of hyperlipidemia. In this review, we provide brief overviews about advances in miRNAs in hyperlipidemia and its potential clinical application value. |
| format | Article |
| id | doaj-art-4948049c4bcb4fc8ac97e4b468211de2 |
| institution | Kabale University |
| issn | 1466-1861 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-4948049c4bcb4fc8ac97e4b468211de22025-08-20T03:36:48ZengWileyMediators of Inflammation1466-18612022-01-01202210.1155/2022/3101900The Role of MicroRNAs in Hyperlipidemia: From Pathogenesis to Therapeutical ApplicationYu Xiang0Li Mao1Mei-Ling Zuo2Gui-Lin Song3Li-Ming Tan4Zhong-Bao Yang5The Affiliated Changsha Hospital of Hunan Normal UniversityDepartment of Basic MedicineThe Affiliated Changsha Hospital of Hunan Normal UniversityThe Affiliated Changsha Hospital of Hunan Normal UniversityThe Affiliated Changsha Hospital of Hunan Normal UniversityThe Affiliated Changsha Hospital of Hunan Normal UniversityHyperlipidemia is a common metabolic disorder with high morbidity and mortality, which brings heavy burden on social. Understanding its pathogenesis and finding its potential therapeutic targets are the focus of current research in this field. In recent years, an increasing number of studies have proved that miRNAs play vital roles in regulating lipid metabolism and were considered as promising therapeutic targets for hyperlipidemia and related diseases. It is demonstrated that miR-191, miR-222, miR-224, miR-27a, miR-378a-3p, miR-140-5p, miR-483, and miR-520d-5p were closely associated with the pathogenesis of hyperlipidemia. In this review, we provide brief overviews about advances in miRNAs in hyperlipidemia and its potential clinical application value.http://dx.doi.org/10.1155/2022/3101900 |
| spellingShingle | Yu Xiang Li Mao Mei-Ling Zuo Gui-Lin Song Li-Ming Tan Zhong-Bao Yang The Role of MicroRNAs in Hyperlipidemia: From Pathogenesis to Therapeutical Application Mediators of Inflammation |
| title | The Role of MicroRNAs in Hyperlipidemia: From Pathogenesis to Therapeutical Application |
| title_full | The Role of MicroRNAs in Hyperlipidemia: From Pathogenesis to Therapeutical Application |
| title_fullStr | The Role of MicroRNAs in Hyperlipidemia: From Pathogenesis to Therapeutical Application |
| title_full_unstemmed | The Role of MicroRNAs in Hyperlipidemia: From Pathogenesis to Therapeutical Application |
| title_short | The Role of MicroRNAs in Hyperlipidemia: From Pathogenesis to Therapeutical Application |
| title_sort | role of micrornas in hyperlipidemia from pathogenesis to therapeutical application |
| url | http://dx.doi.org/10.1155/2022/3101900 |
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