Selective serotonin reuptake inhibitors induce cardiac toxicity through dysfunction of mitochondria and sarcomeres

Selective serotonin reuptake inhibitors induce cardiac toxicity through dysfunction of mitochondria and sarcomeres

Abstract The administration of selective serotonin reuptake inhibitors (SSRIs) during pregnancy can increase the odds of congenital heart defects in babies. The present study aims to explore the toxic effects of SSRIs on the cardiac systems and the underlying mechanism. We apply human pluripotent st...

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Bibliographic Details
Main Authors: Yawei Shen, Cameron E. Brown, Xiao Li, Peng Zhang, Stacey R. McGee, Søren C. Spina, J. Ricardo Loret de Mola, Joanna L. Fiddler, Haodi Wu, Qing Liu
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08168-8
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