Structure and function of a near fully-activated intermediate GPCR-Gαβγ complex

Structure and function of a near fully-activated intermediate GPCR-Gαβγ complex

Abstract Unraveling the signaling roles of intermediate complexes is pivotal for G protein-coupled receptor (GPCR) drug development. Despite hundreds of GPCR-Gαβγ structures, these snapshots primarily capture the fully activated complex. Consequently, the functions of intermediate GPCR-G protein com...

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Bibliographic Details
Main Authors: Maxine Bi, Xudong Wang, Jinan Wang, Jun Xu, Wenkai Sun, Victor Ayo Adediwura, Yinglong Miao, Yifan Cheng, Libin Ye
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56434-4
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