Transcriptomics, single-cell sequencing and spatial sequencing-based studies of cerebral ischemia
Abstract With high disability and mortality rate as well as highly complex pathogenesis, cerebral ischemia is highly morbid, prone to recurrence. To comprehensively understand the pathophysiological process of cerebral ischemia and to find new therapeutic strategies, a new approach to cerebral ische...
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| Format: | Article |
| Language: | English |
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BMC
2025-04-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-025-02596-2 |
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| author | Jiaming Liu Tao Qing Mei he Liu Xu Zhuxiang Wu Meiting Huang Zheyu Liu Ye Zhang Zisheng Li Wenhui Yang Junbo Liu Jie Li |
| author_facet | Jiaming Liu Tao Qing Mei he Liu Xu Zhuxiang Wu Meiting Huang Zheyu Liu Ye Zhang Zisheng Li Wenhui Yang Junbo Liu Jie Li |
| author_sort | Jiaming Liu |
| collection | DOAJ |
| description | Abstract With high disability and mortality rate as well as highly complex pathogenesis, cerebral ischemia is highly morbid, prone to recurrence. To comprehensively understand the pathophysiological process of cerebral ischemia and to find new therapeutic strategies, a new approach to cerebral ischemia transcriptomics has emerged in recent years. By integrating data from multiple levels of transcriptomics, such as transcriptomics, single-cell transcriptomics, and spatial transcriptomics, this new approach can provide powerful help in revealing the molecular mechanisms of cerebral ischemia occurrence and development. Key findings highlight the critical roles of inflammation, blood–brain barrier dysfunction, and mitochondrial dysregulation in cerebral ischemia, offering potential biomarkers and therapeutic targets for early diagnosis and personalized treatment. A review of the research progress of cerebral ischemic injury mechanism under the analysis of the comprehensive transcriptomics research method was presented in this article, aiming to study the potential mechanism to provide new, innovative therapeutic strategies for this disease. |
| format | Article |
| id | doaj-art-493ac38e597f4f019abdcf3d3b4bc761 |
| institution | DOAJ |
| issn | 2047-783X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj-art-493ac38e597f4f019abdcf3d3b4bc7612025-08-20T03:14:05ZengBMCEuropean Journal of Medical Research2047-783X2025-04-0130111810.1186/s40001-025-02596-2Transcriptomics, single-cell sequencing and spatial sequencing-based studies of cerebral ischemiaJiaming Liu0Tao Qing1Mei he2Liu Xu3Zhuxiang Wu4Meiting Huang5Zheyu Liu6Ye Zhang7Zisheng Li8Wenhui Yang9Junbo Liu10Jie Li11Basic Medical College of Hunan University of MedicineBasic Medical College of Hunan University of MedicineHunan Provincial Maternal and Child Health Care HospitalInternational Education School, Hunan University of MedicineBasic Medical College of Hunan University of MedicineBasic Medical College of Hunan University of MedicineBasic Medical College of Hunan University of MedicineBasic Medical College of Hunan University of MedicineBasic Medical College of Hunan University of MedicineBasic Medical College of Hunan University of MedicineBasic Medical College of Hunan University of MedicineBasic Medical College of Hunan University of MedicineAbstract With high disability and mortality rate as well as highly complex pathogenesis, cerebral ischemia is highly morbid, prone to recurrence. To comprehensively understand the pathophysiological process of cerebral ischemia and to find new therapeutic strategies, a new approach to cerebral ischemia transcriptomics has emerged in recent years. By integrating data from multiple levels of transcriptomics, such as transcriptomics, single-cell transcriptomics, and spatial transcriptomics, this new approach can provide powerful help in revealing the molecular mechanisms of cerebral ischemia occurrence and development. Key findings highlight the critical roles of inflammation, blood–brain barrier dysfunction, and mitochondrial dysregulation in cerebral ischemia, offering potential biomarkers and therapeutic targets for early diagnosis and personalized treatment. A review of the research progress of cerebral ischemic injury mechanism under the analysis of the comprehensive transcriptomics research method was presented in this article, aiming to study the potential mechanism to provide new, innovative therapeutic strategies for this disease.https://doi.org/10.1186/s40001-025-02596-2Cerebral ischemiaTranscriptomicsSingle-cell transcriptomicsSpatial transcriptomicsMulti-omics study |
| spellingShingle | Jiaming Liu Tao Qing Mei he Liu Xu Zhuxiang Wu Meiting Huang Zheyu Liu Ye Zhang Zisheng Li Wenhui Yang Junbo Liu Jie Li Transcriptomics, single-cell sequencing and spatial sequencing-based studies of cerebral ischemia European Journal of Medical Research Cerebral ischemia Transcriptomics Single-cell transcriptomics Spatial transcriptomics Multi-omics study |
| title | Transcriptomics, single-cell sequencing and spatial sequencing-based studies of cerebral ischemia |
| title_full | Transcriptomics, single-cell sequencing and spatial sequencing-based studies of cerebral ischemia |
| title_fullStr | Transcriptomics, single-cell sequencing and spatial sequencing-based studies of cerebral ischemia |
| title_full_unstemmed | Transcriptomics, single-cell sequencing and spatial sequencing-based studies of cerebral ischemia |
| title_short | Transcriptomics, single-cell sequencing and spatial sequencing-based studies of cerebral ischemia |
| title_sort | transcriptomics single cell sequencing and spatial sequencing based studies of cerebral ischemia |
| topic | Cerebral ischemia Transcriptomics Single-cell transcriptomics Spatial transcriptomics Multi-omics study |
| url | https://doi.org/10.1186/s40001-025-02596-2 |
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