Effect of 3-hydrazinylquinoxaline-2-thiol hydrogel on skin wound healing process in diabetic rats
Abstract Impaired wound healing in diabetic individuals creates huge social and financial burdens for both diabetic patients and the health system. Unfortunately, the current treatment has not resulted in consistently lower amputation rates. Quinoxalines are heterocyclic compounds with multiple impo...
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Nature Portfolio
2024-08-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-70849-x |
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| author | Jehan Barakat Alamre Huda Alkreathy Ahmed S. Ali Abdelbagi Alfadil Sahar S. Alghamdi |
| author_facet | Jehan Barakat Alamre Huda Alkreathy Ahmed S. Ali Abdelbagi Alfadil Sahar S. Alghamdi |
| author_sort | Jehan Barakat Alamre |
| collection | DOAJ |
| description | Abstract Impaired wound healing in diabetic individuals creates huge social and financial burdens for both diabetic patients and the health system. Unfortunately, the current treatment has not resulted in consistently lower amputation rates. Quinoxalines are heterocyclic compounds with multiple important pharmacological properties. Their effect on wound healing have not been closely studied. In the current work, the wound healing effect of 3-hydrazinylquinoxaline-2-thiol hydrogel is tested topically in a full-thickness excision wound in streptozotocin-induced type 1 diabetic rats. We examined the wound closure rate, expression of inflammatory factors, growth factors in addition to the histological analysis. The results revealed a significant acceleration in wound closure in the treated group compared with the control experimental animals. Histological data demonstrated enhanced re-epithelialization and collagen disposition. The healing effect was additionally evaluated by the inhibition of the inflammatory response of interleukin (IL)—1β interleukin (IL)—6, tumor necrosis factor (TNF-α) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) with a marked improvement of the transforming growth factor beta (TGFβ-1), antioxidant markers and collagen-1. In silico study indicated a favorable drug-like properties and toxicity profile. The present work showed that 3-hydrazinylquinoxaline-2-thiol holds great potential for the treatment of diabetic wounds. |
| format | Article |
| id | doaj-art-4935bf7532964703a548416308238fd8 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-4935bf7532964703a548416308238fd82025-02-09T12:38:18ZengNature PortfolioScientific Reports2045-23222024-08-0114111410.1038/s41598-024-70849-xEffect of 3-hydrazinylquinoxaline-2-thiol hydrogel on skin wound healing process in diabetic ratsJehan Barakat Alamre0Huda Alkreathy1Ahmed S. Ali2Abdelbagi Alfadil3Sahar S. Alghamdi4Department of Clinical Pharmacology, Faculty of Medicine, King Abdulaziz UniversityDepartment of Clinical Pharmacology, Faculty of Medicine, King Abdulaziz UniversityDepartment of Clinical Pharmacology, Faculty of Medicine, King Abdulaziz UniversityDepartment of Clinical Microbiology and Immunology, Faculty of Medicine, King Abdulaziz UniversityDepartment of Pharmaceutical Sciences, College of Pharmacy, King Saud Bin Abdulaziz University for Health Sciences (KSAU-HS)Abstract Impaired wound healing in diabetic individuals creates huge social and financial burdens for both diabetic patients and the health system. Unfortunately, the current treatment has not resulted in consistently lower amputation rates. Quinoxalines are heterocyclic compounds with multiple important pharmacological properties. Their effect on wound healing have not been closely studied. In the current work, the wound healing effect of 3-hydrazinylquinoxaline-2-thiol hydrogel is tested topically in a full-thickness excision wound in streptozotocin-induced type 1 diabetic rats. We examined the wound closure rate, expression of inflammatory factors, growth factors in addition to the histological analysis. The results revealed a significant acceleration in wound closure in the treated group compared with the control experimental animals. Histological data demonstrated enhanced re-epithelialization and collagen disposition. The healing effect was additionally evaluated by the inhibition of the inflammatory response of interleukin (IL)—1β interleukin (IL)—6, tumor necrosis factor (TNF-α) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) with a marked improvement of the transforming growth factor beta (TGFβ-1), antioxidant markers and collagen-1. In silico study indicated a favorable drug-like properties and toxicity profile. The present work showed that 3-hydrazinylquinoxaline-2-thiol holds great potential for the treatment of diabetic wounds.https://doi.org/10.1038/s41598-024-70849-xQuinoxalineInflammationWound healingHydrogelCollagen-1 |
| spellingShingle | Jehan Barakat Alamre Huda Alkreathy Ahmed S. Ali Abdelbagi Alfadil Sahar S. Alghamdi Effect of 3-hydrazinylquinoxaline-2-thiol hydrogel on skin wound healing process in diabetic rats Scientific Reports Quinoxaline Inflammation Wound healing Hydrogel Collagen-1 |
| title | Effect of 3-hydrazinylquinoxaline-2-thiol hydrogel on skin wound healing process in diabetic rats |
| title_full | Effect of 3-hydrazinylquinoxaline-2-thiol hydrogel on skin wound healing process in diabetic rats |
| title_fullStr | Effect of 3-hydrazinylquinoxaline-2-thiol hydrogel on skin wound healing process in diabetic rats |
| title_full_unstemmed | Effect of 3-hydrazinylquinoxaline-2-thiol hydrogel on skin wound healing process in diabetic rats |
| title_short | Effect of 3-hydrazinylquinoxaline-2-thiol hydrogel on skin wound healing process in diabetic rats |
| title_sort | effect of 3 hydrazinylquinoxaline 2 thiol hydrogel on skin wound healing process in diabetic rats |
| topic | Quinoxaline Inflammation Wound healing Hydrogel Collagen-1 |
| url | https://doi.org/10.1038/s41598-024-70849-x |
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