CD8+ cells and small viral reservoirs facilitate post-ART control of SIV replication in M3+ Mauritian cynomolgus macaques initiated on ART two weeks post-infection.

CD8+ cells and small viral reservoirs facilitate post-ART control of SIV replication in M3+ Mauritian cynomolgus macaques initiated on ART two weeks post-infection.

Sustainable HIV remission after antiretroviral therapy (ART) withdrawal, or post-treatment control (PTC), remains a top priority for HIV treatment. We observed surprising PTC in an MHC-haplomatched cohort of MHC-M3+ SIVmac239+ Mauritian cynomolgus macaques (MCMs) initiated on ART at two weeks post-i...

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Bibliographic Details
Main Authors: Olivia E Harwood, Lea M Matschke, Ryan V Moriarty, Alexis J Balgeman, Abigail J Weaver, Amy L Ellis-Connell, Andrea M Weiler, Lee C Winchester, Courtney V Fletcher, Thomas C Friedrich, Brandon F Keele, David H O'Connor, Jessica D Lang, Matthew R Reynolds, Shelby L O'Connor
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-09-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011676&type=printable
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