Spatial-Temporal Patterns and Inflammatory Factors of Bone Matrix Remodeling
The bone extracellular matrix (ECM) contains organic and mineral constituents. The establishment and degradation processes of ECM connect with spatial and temporal patterns, especially circadian rhythms in ECM. These patterns are responsible for the physical and biological characteristics of bone. T...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2021/4307961 |
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| _version_ | 1832547075606183936 |
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| author | Jiechen Wang Fengyuan Guo Guangjin Chen Jiwei Sun Qingming Tang Lili Chen |
| author_facet | Jiechen Wang Fengyuan Guo Guangjin Chen Jiwei Sun Qingming Tang Lili Chen |
| author_sort | Jiechen Wang |
| collection | DOAJ |
| description | The bone extracellular matrix (ECM) contains organic and mineral constituents. The establishment and degradation processes of ECM connect with spatial and temporal patterns, especially circadian rhythms in ECM. These patterns are responsible for the physical and biological characteristics of bone. The disturbances of the patterns disrupt bone matrix remodeling and cause diverse bone diseases, such as osteogenesis imperfecta (OI) and bone fracture. In addition, the main regulatory factors and inflammatory factors also follow circadian rhythms. Studies show that the circadian oscillations of these factors in bone ECM potentially influence the interactions between immune responses and bone formation. More importantly, mesenchymal stem cells (MSCs) within the specific microenvironments provide the regenerative potential for tissue remodeling. In this review, we summarize the advanced ECM spatial characteristics and the periodic patterns of bone ECM. Importantly, we focus on the intrinsic connections between the immunoinflammatory system and bone formation according to circadian rhythms of regulatory factors in bone ECM. And our research group emphasizes the multipotency of MSCs with their microenvironments. The advanced understandings of bone ECM formation patterns and MSCs contribute to providing optimal prevention and treatment strategies. |
| format | Article |
| id | doaj-art-4919454d15b64ed5a985a720caef493a |
| institution | Kabale University |
| issn | 1687-9678 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-4919454d15b64ed5a985a720caef493a2025-02-03T06:46:09ZengWileyStem Cells International1687-96782021-01-01202110.1155/2021/4307961Spatial-Temporal Patterns and Inflammatory Factors of Bone Matrix RemodelingJiechen Wang0Fengyuan Guo1Guangjin Chen2Jiwei Sun3Qingming Tang4Lili Chen5Department of StomatologyDepartment of StomatologyDepartment of StomatologyDepartment of StomatologyDepartment of StomatologyDepartment of StomatologyThe bone extracellular matrix (ECM) contains organic and mineral constituents. The establishment and degradation processes of ECM connect with spatial and temporal patterns, especially circadian rhythms in ECM. These patterns are responsible for the physical and biological characteristics of bone. The disturbances of the patterns disrupt bone matrix remodeling and cause diverse bone diseases, such as osteogenesis imperfecta (OI) and bone fracture. In addition, the main regulatory factors and inflammatory factors also follow circadian rhythms. Studies show that the circadian oscillations of these factors in bone ECM potentially influence the interactions between immune responses and bone formation. More importantly, mesenchymal stem cells (MSCs) within the specific microenvironments provide the regenerative potential for tissue remodeling. In this review, we summarize the advanced ECM spatial characteristics and the periodic patterns of bone ECM. Importantly, we focus on the intrinsic connections between the immunoinflammatory system and bone formation according to circadian rhythms of regulatory factors in bone ECM. And our research group emphasizes the multipotency of MSCs with their microenvironments. The advanced understandings of bone ECM formation patterns and MSCs contribute to providing optimal prevention and treatment strategies.http://dx.doi.org/10.1155/2021/4307961 |
| spellingShingle | Jiechen Wang Fengyuan Guo Guangjin Chen Jiwei Sun Qingming Tang Lili Chen Spatial-Temporal Patterns and Inflammatory Factors of Bone Matrix Remodeling Stem Cells International |
| title | Spatial-Temporal Patterns and Inflammatory Factors of Bone Matrix Remodeling |
| title_full | Spatial-Temporal Patterns and Inflammatory Factors of Bone Matrix Remodeling |
| title_fullStr | Spatial-Temporal Patterns and Inflammatory Factors of Bone Matrix Remodeling |
| title_full_unstemmed | Spatial-Temporal Patterns and Inflammatory Factors of Bone Matrix Remodeling |
| title_short | Spatial-Temporal Patterns and Inflammatory Factors of Bone Matrix Remodeling |
| title_sort | spatial temporal patterns and inflammatory factors of bone matrix remodeling |
| url | http://dx.doi.org/10.1155/2021/4307961 |
| work_keys_str_mv | AT jiechenwang spatialtemporalpatternsandinflammatoryfactorsofbonematrixremodeling AT fengyuanguo spatialtemporalpatternsandinflammatoryfactorsofbonematrixremodeling AT guangjinchen spatialtemporalpatternsandinflammatoryfactorsofbonematrixremodeling AT jiweisun spatialtemporalpatternsandinflammatoryfactorsofbonematrixremodeling AT qingmingtang spatialtemporalpatternsandinflammatoryfactorsofbonematrixremodeling AT lilichen spatialtemporalpatternsandinflammatoryfactorsofbonematrixremodeling |