Molecular insights and clinical implications of DNA methylation in sepsis-associated acute kidney injury: a narrative review

Molecular insights and clinical implications of DNA methylation in sepsis-associated acute kidney injury: a narrative review

Abstract Sepsis-induced acute kidney injury (S-AKI) is a life-threatening complication of sepsis, marked by dysregulated inflammation, metabolic derangements, and immune dysfunction, driving high mortality. Its multifactorial pathogenesis increasingly implicates DNA methylation-a core epigenetic mec...

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Bibliographic Details
Main Authors: Lili Liu, Saisai Ni, Lianna Zhang, Yingying Chen, Mengqi Xie, Xiaojing Huang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Nephrology
Subjects:
Sepsis
Acute kidney injury
DNA methylation
Epigenetics
Inflammation
Biomarkers
Online Access:https://doi.org/10.1186/s12882-025-04179-z
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