A pan-orthohantavirus human lung xenograft mouse model and its utility for preclinical studies.

A pan-orthohantavirus human lung xenograft mouse model and its utility for preclinical studies.

Orthohantaviruses are emerging zoonotic viruses that can infect humans via the respiratory tract. There is an unmet need for an in vivo model to study infection of different orthohantaviruses in physiologically relevant tissue and to assess the efficacy of novel pan-orthohantavirus countermeasures....

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Main Authors: Melanie Rissmann, Danny Noack, Thomas M Spliethof, Vincent P Vaes, Rianne Stam, Peter van Run, Jordan J Clark, Georges M G M Verjans, Bart L Haagmans, Florian Krammer, Marion P G Koopmans, Judith M A van den Brand, Barry Rockx
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012875
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