Colonic invasive adenocarcinoma with squamoid morules: A case report
Abstract Colorectal adenomas with squamoid morules are rare; however, colorectal adenocarcinomas are even rarer. Herein, we present a case of colorectal adenocarcinoma with squamoid morules arising from the transverse colon. A 60‐year‐old Japanese man underwent a colonoscopy, and a Type 0‐Is polyp w...
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| Format: | Article |
| Language: | English |
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Wiley
2024-04-01
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| Series: | DEN Open |
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| Online Access: | https://doi.org/10.1002/deo2.330 |
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| author | Akira Ishikawa Hidenori Tanaka Ken Yamashita Koji Arihiro Shiro Oka Manabu Shimomura Hideki Ohdan |
| author_facet | Akira Ishikawa Hidenori Tanaka Ken Yamashita Koji Arihiro Shiro Oka Manabu Shimomura Hideki Ohdan |
| author_sort | Akira Ishikawa |
| collection | DOAJ |
| description | Abstract Colorectal adenomas with squamoid morules are rare; however, colorectal adenocarcinomas are even rarer. Herein, we present a case of colorectal adenocarcinoma with squamoid morules arising from the transverse colon. A 60‐year‐old Japanese man underwent a colonoscopy, and a Type 0‐Is polyp was detected in the transverse colon. The endoscopic findings suggested a high possibility of carcinoma invasion into the deep submucosa. However, endoscopic mucosal resection was performed due to the patient's preference. Histopathologically, the tumor cells mostly formed atypical glandular structures corresponding to adenocarcinomas. Solid nests were observed in parts of the tumor, composed of round, small to short spindles. Immunohistochemically, p63 was positive in some areas, CK20 was negative, and the Ki‐67 positive cell rate was almost zero, suggesting a squamoid morule. Based on the above findings, colorectal adenocarcinoma with a squamoid morule was diagnosed; only the fifth case was reported worldwide. Squamoid morules should be carefully differentiated from squamous components of adenosquamous carcinomas. |
| format | Article |
| id | doaj-art-491248c4d30f4764be151c5681b34b4f |
| institution | Kabale University |
| issn | 2692-4609 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | DEN Open |
| spelling | doaj-art-491248c4d30f4764be151c5681b34b4f2025-08-20T03:41:00ZengWileyDEN Open2692-46092024-04-0141n/an/a10.1002/deo2.330Colonic invasive adenocarcinoma with squamoid morules: A case reportAkira Ishikawa0Hidenori Tanaka1Ken Yamashita2Koji Arihiro3Shiro Oka4Manabu Shimomura5Hideki Ohdan6Department of Molecular Pathology Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Gastroenterology Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Gastroenterology Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Anatomical Pathology Hiroshima University Hospital Hiroshima JapanDepartment of Gastroenterology Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Gastroenterological and Transplant Surgery Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Gastroenterological and Transplant Surgery Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima JapanAbstract Colorectal adenomas with squamoid morules are rare; however, colorectal adenocarcinomas are even rarer. Herein, we present a case of colorectal adenocarcinoma with squamoid morules arising from the transverse colon. A 60‐year‐old Japanese man underwent a colonoscopy, and a Type 0‐Is polyp was detected in the transverse colon. The endoscopic findings suggested a high possibility of carcinoma invasion into the deep submucosa. However, endoscopic mucosal resection was performed due to the patient's preference. Histopathologically, the tumor cells mostly formed atypical glandular structures corresponding to adenocarcinomas. Solid nests were observed in parts of the tumor, composed of round, small to short spindles. Immunohistochemically, p63 was positive in some areas, CK20 was negative, and the Ki‐67 positive cell rate was almost zero, suggesting a squamoid morule. Based on the above findings, colorectal adenocarcinoma with a squamoid morule was diagnosed; only the fifth case was reported worldwide. Squamoid morules should be carefully differentiated from squamous components of adenosquamous carcinomas.https://doi.org/10.1002/deo2.330coloncolorectal cancerdifferential diagnosissquamoid moruleadenocarcinoma with squamoid morules |
| spellingShingle | Akira Ishikawa Hidenori Tanaka Ken Yamashita Koji Arihiro Shiro Oka Manabu Shimomura Hideki Ohdan Colonic invasive adenocarcinoma with squamoid morules: A case report DEN Open colon colorectal cancer differential diagnosis squamoid morule adenocarcinoma with squamoid morules |
| title | Colonic invasive adenocarcinoma with squamoid morules: A case report |
| title_full | Colonic invasive adenocarcinoma with squamoid morules: A case report |
| title_fullStr | Colonic invasive adenocarcinoma with squamoid morules: A case report |
| title_full_unstemmed | Colonic invasive adenocarcinoma with squamoid morules: A case report |
| title_short | Colonic invasive adenocarcinoma with squamoid morules: A case report |
| title_sort | colonic invasive adenocarcinoma with squamoid morules a case report |
| topic | colon colorectal cancer differential diagnosis squamoid morule adenocarcinoma with squamoid morules |
| url | https://doi.org/10.1002/deo2.330 |
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