Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i): Mechanisms of resistance and where to find them

Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i): Mechanisms of resistance and where to find them

CDK4/6 inhibitors (CDK4/6i) have significantly impacted on the treatment of HR + HER2 negative (HER2-) metastatic breast cancer (BC) when combined with endocrine therapy. Nonetheless, despite significant research efforts, the mechanisms of de novo and acquired resistance to CDK4/6i have not yet been...

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Bibliographic Details
Main Authors: L. Foffano, L. Cucciniello, E. Nicolò, I. Migliaccio, C. Noto, C. Reduzzi, L. Malorni, M. Cristofanilli, L. Gerratana, F. Puglisi
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Breast
Subjects:
Metastatic breast cancer
CDK 4/6 inhibitors resistance
Liquid biopsy
Online Access:http://www.sciencedirect.com/science/article/pii/S0960977624001942
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