Vestibular Evoked Myogenic Potentials (VEMPs) in Parkinson’s Disease Patients with Monopolar Deep Brain Stimulation
Whilst balance disturbances are common in people with advanced Parkinson’s disease, it has not previously been possible to record vestibular evoked myogenic potentials (VEMPs), and thus otolithic function, during monopolar deep brain stimulation (DBS) due to an overwhelming number of signal artifact...
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MDPI AG
2025-02-01
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| Online Access: | https://www.mdpi.com/2624-6120/6/1/10 |
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| author | Kim E. Hawkins John Holden Elodie Chiarovano Simon J. G. Lewis Ian S. Curthoys Hamish G. MacDougall |
| author_facet | Kim E. Hawkins John Holden Elodie Chiarovano Simon J. G. Lewis Ian S. Curthoys Hamish G. MacDougall |
| author_sort | Kim E. Hawkins |
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| description | Whilst balance disturbances are common in people with advanced Parkinson’s disease, it has not previously been possible to record vestibular evoked myogenic potentials (VEMPs), and thus otolithic function, during monopolar deep brain stimulation (DBS) due to an overwhelming number of signal artifacts. A µVEMP device has been developed with parameters to allow VEMP recording during monopolar DBS. The aim of this proof-of-concept study was to ascertain whether, during DBS, VEMP responses could be accurately identified after signal filtering recordings from the µVEMP device. Both cervical and ocular VEMP responses to taps and clicks were recorded with the µVEMP device in five Parkinson’s disease patients with monopolar deep brain stimulation. Additionally, VEMP responses were recorded in one patient whose deep brain stimulation was switched ON and OFF to allow a direct comparison of the signals. Customised post-filtering analysis allowed successful VEMP response extraction from signal noise in all five patients with deep brain stimulation ON. VEMP responses with deep brain stimulation ON after filtering were similar to VEMP responses with deep brain stimulation OFF, validating the filtering analysis. We present the first study to record VEMP signals with monopolar deep brain stimulation using a µVEMP device coupled with customised post-filtering. This finding will allow patients to be assessed without requiring adjustment of their therapeutic deep brain stimulation. |
| format | Article |
| id | doaj-art-49055dc002a14f7b87dea5936d5d41ea |
| institution | OA Journals |
| issn | 2624-6120 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
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| spelling | doaj-art-49055dc002a14f7b87dea5936d5d41ea2025-08-20T01:49:03ZengMDPI AGSignals2624-61202025-02-01611010.3390/signals6010010Vestibular Evoked Myogenic Potentials (VEMPs) in Parkinson’s Disease Patients with Monopolar Deep Brain StimulationKim E. Hawkins0John Holden1Elodie Chiarovano2Simon J. G. Lewis3Ian S. Curthoys4Hamish G. MacDougall5School of Psychology, Faculty of Science, The University of Sydney, Sydney, NSW 2050, AustraliaSchool of Psychology, Faculty of Science, The University of Sydney, Sydney, NSW 2050, AustraliaSchool of Psychology, Faculty of Science, The University of Sydney, Sydney, NSW 2050, AustraliaParkinson’s Disease Research Clinic, Macquarie Medical School, Macquarie University, Sydney, NSW 2109, AustraliaSchool of Psychology, Faculty of Science, The University of Sydney, Sydney, NSW 2050, AustraliaBionics Institute, St. Vincent’s Hospital, 41 Victoria Parade Fitzroy, Fitzroy, VIC 3065, AustraliaWhilst balance disturbances are common in people with advanced Parkinson’s disease, it has not previously been possible to record vestibular evoked myogenic potentials (VEMPs), and thus otolithic function, during monopolar deep brain stimulation (DBS) due to an overwhelming number of signal artifacts. A µVEMP device has been developed with parameters to allow VEMP recording during monopolar DBS. The aim of this proof-of-concept study was to ascertain whether, during DBS, VEMP responses could be accurately identified after signal filtering recordings from the µVEMP device. Both cervical and ocular VEMP responses to taps and clicks were recorded with the µVEMP device in five Parkinson’s disease patients with monopolar deep brain stimulation. Additionally, VEMP responses were recorded in one patient whose deep brain stimulation was switched ON and OFF to allow a direct comparison of the signals. Customised post-filtering analysis allowed successful VEMP response extraction from signal noise in all five patients with deep brain stimulation ON. VEMP responses with deep brain stimulation ON after filtering were similar to VEMP responses with deep brain stimulation OFF, validating the filtering analysis. We present the first study to record VEMP signals with monopolar deep brain stimulation using a µVEMP device coupled with customised post-filtering. This finding will allow patients to be assessed without requiring adjustment of their therapeutic deep brain stimulation.https://www.mdpi.com/2624-6120/6/1/10vestibularParkinson’s diseaseDBSVEMPsignal filteringnoise artifacts |
| spellingShingle | Kim E. Hawkins John Holden Elodie Chiarovano Simon J. G. Lewis Ian S. Curthoys Hamish G. MacDougall Vestibular Evoked Myogenic Potentials (VEMPs) in Parkinson’s Disease Patients with Monopolar Deep Brain Stimulation Signals vestibular Parkinson’s disease DBS VEMP signal filtering noise artifacts |
| title | Vestibular Evoked Myogenic Potentials (VEMPs) in Parkinson’s Disease Patients with Monopolar Deep Brain Stimulation |
| title_full | Vestibular Evoked Myogenic Potentials (VEMPs) in Parkinson’s Disease Patients with Monopolar Deep Brain Stimulation |
| title_fullStr | Vestibular Evoked Myogenic Potentials (VEMPs) in Parkinson’s Disease Patients with Monopolar Deep Brain Stimulation |
| title_full_unstemmed | Vestibular Evoked Myogenic Potentials (VEMPs) in Parkinson’s Disease Patients with Monopolar Deep Brain Stimulation |
| title_short | Vestibular Evoked Myogenic Potentials (VEMPs) in Parkinson’s Disease Patients with Monopolar Deep Brain Stimulation |
| title_sort | vestibular evoked myogenic potentials vemps in parkinson s disease patients with monopolar deep brain stimulation |
| topic | vestibular Parkinson’s disease DBS VEMP signal filtering noise artifacts |
| url | https://www.mdpi.com/2624-6120/6/1/10 |
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