HLA class II neoantigen presentation for CD4+ T cell surveillance in HLA class II-negative colorectal cancer

HLA class II neoantigen presentation for CD4+ T cell surveillance in HLA class II-negative colorectal cancer

Neoantigen-reactive CD4+ T cells play a key role in the anti-tumor immune response. However, the majority of epithelial tumors are negative for HLA class II (HLA-II) surface expression, and less is known about the processing of HLA-II antigens. Here, we directly identified naturally presented HLA-II...

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Bibliographic Details
Main Authors: Satoru Matsumoto, Takahiro Tsujikawa, Serina Tokita, Mai Mohamed Bedeir, Kazuhiko Matsuo, Fumitake Hata, Yoshihiko Hirohashi, Takayuki Kanaseki, Toshihiko Torigoe
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:OncoImmunology
Subjects:
Antigen presentation
HLA class II
neoantigen
tertiary lymphoid structures
Th1 cells
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2024.2404665
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