Hyaluronan Immobilized Polyurethane as a Blood Contacting Material
Hyaluronan (hyaluronic acid, HA) was immobilized onto the surface of amino-functionalized polyurethane films with the goal of obtaining a novel kind of biomaterial which had the potential in blood-contacting applications. The amino-functionalized polyurethane was prepared by synthesized acidic polyu...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2010/807935 |
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| _version_ | 1832558720115015680 |
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| author | Feirong Gong Yue Lu Hui Guo Shujun Cheng Yun Gao |
| author_facet | Feirong Gong Yue Lu Hui Guo Shujun Cheng Yun Gao |
| author_sort | Feirong Gong |
| collection | DOAJ |
| description | Hyaluronan (hyaluronic acid, HA) was immobilized onto the surface of amino-functionalized polyurethane films with the goal of obtaining a novel kind of biomaterial which had the potential in blood-contacting applications. The amino-functionalized polyurethane was prepared by synthesized acidic polyurethane whose pendant carboxyl groups were treated with an excess amount of 1,3-diaminopropane in the presence of N,N-carbonyldiimidazole (CDI). Attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), Raman spectroscopy (RS), scanning electron microscopy (SEM), and water contact angle measurement were used to confirm the surface changes at each step of treatment, both in morphologies and chemical compositions. APTT and PT results showed that HA immobilization could prolong the blood coagulation time, thus HA-immobilized polyurethane (PU-HA) exhibited improved blood compatibility. Cytotoxicity analysis showed that the PU-HA films synthesized in this study were cytocompatible and could support human vein endothelial cells (HUVECs) adhesion and proliferation. |
| format | Article |
| id | doaj-art-48fb7bc5d1aa4c829b4a220dca7267ad |
| institution | Kabale University |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-48fb7bc5d1aa4c829b4a220dca7267ad2025-02-03T01:31:47ZengWileyInternational Journal of Polymer Science1687-94221687-94302010-01-01201010.1155/2010/807935807935Hyaluronan Immobilized Polyurethane as a Blood Contacting MaterialFeirong Gong0Yue Lu1Hui Guo2Shujun Cheng3Yun Gao4Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, ChinaKey Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, ChinaKey Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, ChinaKey Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, ChinaKey Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, ChinaHyaluronan (hyaluronic acid, HA) was immobilized onto the surface of amino-functionalized polyurethane films with the goal of obtaining a novel kind of biomaterial which had the potential in blood-contacting applications. The amino-functionalized polyurethane was prepared by synthesized acidic polyurethane whose pendant carboxyl groups were treated with an excess amount of 1,3-diaminopropane in the presence of N,N-carbonyldiimidazole (CDI). Attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), Raman spectroscopy (RS), scanning electron microscopy (SEM), and water contact angle measurement were used to confirm the surface changes at each step of treatment, both in morphologies and chemical compositions. APTT and PT results showed that HA immobilization could prolong the blood coagulation time, thus HA-immobilized polyurethane (PU-HA) exhibited improved blood compatibility. Cytotoxicity analysis showed that the PU-HA films synthesized in this study were cytocompatible and could support human vein endothelial cells (HUVECs) adhesion and proliferation.http://dx.doi.org/10.1155/2010/807935 |
| spellingShingle | Feirong Gong Yue Lu Hui Guo Shujun Cheng Yun Gao Hyaluronan Immobilized Polyurethane as a Blood Contacting Material International Journal of Polymer Science |
| title | Hyaluronan Immobilized Polyurethane as a Blood Contacting Material |
| title_full | Hyaluronan Immobilized Polyurethane as a Blood Contacting Material |
| title_fullStr | Hyaluronan Immobilized Polyurethane as a Blood Contacting Material |
| title_full_unstemmed | Hyaluronan Immobilized Polyurethane as a Blood Contacting Material |
| title_short | Hyaluronan Immobilized Polyurethane as a Blood Contacting Material |
| title_sort | hyaluronan immobilized polyurethane as a blood contacting material |
| url | http://dx.doi.org/10.1155/2010/807935 |
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