High Frequency of Diabetic Ketoacidosis in Children with Newly Diagnosed Type 1 Diabetes
Aim. The aim of this study was to evaluate the incidence of diabetic ketoacidosis in children and adolescents with newly diagnosed type 1 diabetes in 2006-2007 and 2013-2014. Method. The study group consisted of 426 children aged 0–18 years with type 1 diabetes onset admitted to our hospital in 2006...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/9582793 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849405061778636800 |
|---|---|
| author | Agnieszka Szypowska Anna Ramotowska Monika Grzechnik-Gryziak Wojciech Szypowski Anna Pasierb Katarzyna Piechowiak |
| author_facet | Agnieszka Szypowska Anna Ramotowska Monika Grzechnik-Gryziak Wojciech Szypowski Anna Pasierb Katarzyna Piechowiak |
| author_sort | Agnieszka Szypowska |
| collection | DOAJ |
| description | Aim. The aim of this study was to evaluate the incidence of diabetic ketoacidosis in children and adolescents with newly diagnosed type 1 diabetes in 2006-2007 and 2013-2014. Method. The study group consisted of 426 children aged 0–18 years with type 1 diabetes onset admitted to our hospital in 2006-2007 (group A) and 2013-2014 (group B). The study comprised the analysis of medical and laboratory records from patients’ medical charts and the electronic database. Results. There was no difference between groups A and B in the percentage of children admitted with diabetic ketoacidosis (25% versus 28%, resp., P=0.499). Among children with diabetic ketoacidosis, severe metabolic decompensation (pH < 7.1) appeared in similar frequency in groups A and B (28% versus 30%, resp., P=0.110). In group B, children with diabetic ketoacidosis were statistically younger compared to patients without ketoacidosis (P=0.015) and had higher HbA1c levels (P=0.006). In both groups, a 2-fold increase in diabetic ketoacidosis was noted in children under the age of 3, compared to overall frequency. Conclusion. No decrease in diabetic ketoacidosis has been noted in the recent years. Although the prevalence and severity of diabetic ketoacidosis remain stable, they are unacceptably high. The youngest children are especially prone to ketoacidosis. |
| format | Article |
| id | doaj-art-48f940b72e97466bb343b2186e7ed0f2 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-48f940b72e97466bb343b2186e7ed0f22025-08-20T03:36:47ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/95827939582793High Frequency of Diabetic Ketoacidosis in Children with Newly Diagnosed Type 1 DiabetesAgnieszka Szypowska0Anna Ramotowska1Monika Grzechnik-Gryziak2Wojciech Szypowski3Anna Pasierb4Katarzyna Piechowiak5Department of Paediatrics, Medical University of Warsaw, Dzialdowska 1, 01-184 Warsaw, PolandDepartment of Paediatrics, Medical University of Warsaw, Dzialdowska 1, 01-184 Warsaw, PolandDepartment of Paediatrics, Medical University of Warsaw, Dzialdowska 1, 01-184 Warsaw, PolandDepartment of Paediatrics, Medical University of Warsaw, Dzialdowska 1, 01-184 Warsaw, PolandDepartment of Paediatrics, Medical University of Warsaw, Dzialdowska 1, 01-184 Warsaw, PolandDepartment of Paediatrics, Medical University of Warsaw, Dzialdowska 1, 01-184 Warsaw, PolandAim. The aim of this study was to evaluate the incidence of diabetic ketoacidosis in children and adolescents with newly diagnosed type 1 diabetes in 2006-2007 and 2013-2014. Method. The study group consisted of 426 children aged 0–18 years with type 1 diabetes onset admitted to our hospital in 2006-2007 (group A) and 2013-2014 (group B). The study comprised the analysis of medical and laboratory records from patients’ medical charts and the electronic database. Results. There was no difference between groups A and B in the percentage of children admitted with diabetic ketoacidosis (25% versus 28%, resp., P=0.499). Among children with diabetic ketoacidosis, severe metabolic decompensation (pH < 7.1) appeared in similar frequency in groups A and B (28% versus 30%, resp., P=0.110). In group B, children with diabetic ketoacidosis were statistically younger compared to patients without ketoacidosis (P=0.015) and had higher HbA1c levels (P=0.006). In both groups, a 2-fold increase in diabetic ketoacidosis was noted in children under the age of 3, compared to overall frequency. Conclusion. No decrease in diabetic ketoacidosis has been noted in the recent years. Although the prevalence and severity of diabetic ketoacidosis remain stable, they are unacceptably high. The youngest children are especially prone to ketoacidosis.http://dx.doi.org/10.1155/2016/9582793 |
| spellingShingle | Agnieszka Szypowska Anna Ramotowska Monika Grzechnik-Gryziak Wojciech Szypowski Anna Pasierb Katarzyna Piechowiak High Frequency of Diabetic Ketoacidosis in Children with Newly Diagnosed Type 1 Diabetes Journal of Diabetes Research |
| title | High Frequency of Diabetic Ketoacidosis in Children with Newly Diagnosed Type 1 Diabetes |
| title_full | High Frequency of Diabetic Ketoacidosis in Children with Newly Diagnosed Type 1 Diabetes |
| title_fullStr | High Frequency of Diabetic Ketoacidosis in Children with Newly Diagnosed Type 1 Diabetes |
| title_full_unstemmed | High Frequency of Diabetic Ketoacidosis in Children with Newly Diagnosed Type 1 Diabetes |
| title_short | High Frequency of Diabetic Ketoacidosis in Children with Newly Diagnosed Type 1 Diabetes |
| title_sort | high frequency of diabetic ketoacidosis in children with newly diagnosed type 1 diabetes |
| url | http://dx.doi.org/10.1155/2016/9582793 |
| work_keys_str_mv | AT agnieszkaszypowska highfrequencyofdiabeticketoacidosisinchildrenwithnewlydiagnosedtype1diabetes AT annaramotowska highfrequencyofdiabeticketoacidosisinchildrenwithnewlydiagnosedtype1diabetes AT monikagrzechnikgryziak highfrequencyofdiabeticketoacidosisinchildrenwithnewlydiagnosedtype1diabetes AT wojciechszypowski highfrequencyofdiabeticketoacidosisinchildrenwithnewlydiagnosedtype1diabetes AT annapasierb highfrequencyofdiabeticketoacidosisinchildrenwithnewlydiagnosedtype1diabetes AT katarzynapiechowiak highfrequencyofdiabeticketoacidosisinchildrenwithnewlydiagnosedtype1diabetes |