Is Month of Birth a Risk Factor for Colorectal Cancer?
Introduction. The developmental origins of health and disease hypothesis and season of birth have been linked to a wide variety of later life conditions including cancer. Whether any relationship between month and season of birth and colorectal cancer exists is unknown. Methods. A case-control study...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2017/5423765 |
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| author | N. K. Francis N. J. Curtis E. Noble M. Cortina-Borja E. Salib |
| author_facet | N. K. Francis N. J. Curtis E. Noble M. Cortina-Borja E. Salib |
| author_sort | N. K. Francis |
| collection | DOAJ |
| description | Introduction. The developmental origins of health and disease hypothesis and season of birth have been linked to a wide variety of later life conditions including cancer. Whether any relationship between month and season of birth and colorectal cancer exists is unknown. Methods. A case-control study was performed with month of birth extracted from a dedicated colorectal cancer database. Age and gender matched patients were used as a control group. Generalised linear models were fitted with Poisson and negative binomial responses and logarithmic links. A forward stepwise approach was followed adding seasonal components with 6- and 12-month periods. Results. 1019 colorectal cancer patients and 1277 randomly selected age and gender matched controls were included. For both men and women there is an excess of colorectal cancer in those born in autumn and a corresponding reduction of risk among those born in spring (p = 0.026). For the identified September peak, the excess risk for colorectal cancer was 14.8% (95% CI 5.6–32.3%) larger than the spring trough. Conclusion. There is a seasonal effect in the monthly birth rates of people who are operated for colorectal cancer with a disproportionate excess of cancer in those born in September. Further large studies are required to validate these findings. |
| format | Article |
| id | doaj-art-48f8a681abe84230b044ba416a3c27ec |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-48f8a681abe84230b044ba416a3c27ec2025-02-03T05:53:45ZengWileyGastroenterology Research and Practice1687-61211687-630X2017-01-01201710.1155/2017/54237655423765Is Month of Birth a Risk Factor for Colorectal Cancer?N. K. Francis0N. J. Curtis1E. Noble2M. Cortina-Borja3E. Salib4Department of General Surgery, Yeovil District Hospital NHS Foundation Trust, Higher Kingston, Yeovil BA21 4AT, UKDepartment of General Surgery, Yeovil District Hospital NHS Foundation Trust, Higher Kingston, Yeovil BA21 4AT, UKDepartment of General Surgery, Yeovil District Hospital NHS Foundation Trust, Higher Kingston, Yeovil BA21 4AT, UKCentre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, 30 Guilford St, London WC1N 1EH, UKFaculty of Health and Life Sciences, University of Liverpool, Brownlow Hill, Liverpool L69 3BX, UKIntroduction. The developmental origins of health and disease hypothesis and season of birth have been linked to a wide variety of later life conditions including cancer. Whether any relationship between month and season of birth and colorectal cancer exists is unknown. Methods. A case-control study was performed with month of birth extracted from a dedicated colorectal cancer database. Age and gender matched patients were used as a control group. Generalised linear models were fitted with Poisson and negative binomial responses and logarithmic links. A forward stepwise approach was followed adding seasonal components with 6- and 12-month periods. Results. 1019 colorectal cancer patients and 1277 randomly selected age and gender matched controls were included. For both men and women there is an excess of colorectal cancer in those born in autumn and a corresponding reduction of risk among those born in spring (p = 0.026). For the identified September peak, the excess risk for colorectal cancer was 14.8% (95% CI 5.6–32.3%) larger than the spring trough. Conclusion. There is a seasonal effect in the monthly birth rates of people who are operated for colorectal cancer with a disproportionate excess of cancer in those born in September. Further large studies are required to validate these findings.http://dx.doi.org/10.1155/2017/5423765 |
| spellingShingle | N. K. Francis N. J. Curtis E. Noble M. Cortina-Borja E. Salib Is Month of Birth a Risk Factor for Colorectal Cancer? Gastroenterology Research and Practice |
| title | Is Month of Birth a Risk Factor for Colorectal Cancer? |
| title_full | Is Month of Birth a Risk Factor for Colorectal Cancer? |
| title_fullStr | Is Month of Birth a Risk Factor for Colorectal Cancer? |
| title_full_unstemmed | Is Month of Birth a Risk Factor for Colorectal Cancer? |
| title_short | Is Month of Birth a Risk Factor for Colorectal Cancer? |
| title_sort | is month of birth a risk factor for colorectal cancer |
| url | http://dx.doi.org/10.1155/2017/5423765 |
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