Escalated oxycodone self-administration is associated with expression of voltage gated and calcium activated potassium channels in the mesocorticolimbic system in rats

Escalated oxycodone self-administration is associated with expression of voltage gated and calcium activated potassium channels in the mesocorticolimbic system in rats

BackgroundThe number of individuals diagnosed with opioid use disorder (OUD) has risen steeply because of increased prescribing of opioid drugs including oxycodone for chronic pain relief. When rats given extended access to oxycodone only a subset of animals self-administers more drug over time. Ide...

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Bibliographic Details
Main Authors: Ammanuel Y. Wabreha, Nasser Adjei, Bruce Ladenheim, Jean Lud Cadet, Atul P. Daiwile
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
oxycodone
potassium channels
mRNA
prefrontal cortex
nucleus accumbens
hippocampus
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1653356/full
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