Diet modulates the therapeutic effects of dimethyl fumarate mediated by the immunometabolic neutrophil receptor HCAR2

Diet modulates the therapeutic effects of dimethyl fumarate mediated by the immunometabolic neutrophil receptor HCAR2

Monomethyl fumarate (MMF) and its prodrug dimethyl fumarate (DMF) are currently the most widely used agents for the treatment of multiple sclerosis (MS). However, not all patients benefit from DMF. We hypothesized that the variable response of patients may be due to their diet. In support of this hy...

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Main Authors: Joanna Kosinska, Julian C Assmann, Julica Inderhees, Helge Müller-Fielitz, Kristian Händler, Sven Geisler, Axel Künstner, Hauke Busch, Anna Worthmann, Joerg Heeren, Christian D Sadik, Matthias Gunzer, Vincent Prévot, Ruben Nogueiras, Misa Hirose, Malte Spielmann, Stefan Offermanns, Nina Wettschureck, Markus Schwaninger
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-04-01
Series:eLife
Subjects:
multiple sclerosis
neutrophils
experimental autoimmune encephalomyelitis
Online Access:https://elifesciences.org/articles/98970
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