Assessing the diagnostic accuracy of unilateral systematic biopsy combined with targeted biopsy
BackgroundTo evaluate unilateral systematic biopsy (SB) combined with targeted biopsy (TB) and assess its diagnostic accuracy in a real-world, single-centre setting.MethodsPatients with ≥1 MRI lesion who underwent both transperineal 12-core and 3-core TB were enrolled in this study. Detection rates...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1599869/full |
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| author | Qiyou Wu Chunlei He Xiang Tu Bo Chen Jinjiang Jiang Jinbao Wang Zhouhaoran Chen Ruoxuan Liu Qiaoxue Huang Bo Tang Jin Yao Qiang Wei |
| author_facet | Qiyou Wu Chunlei He Xiang Tu Bo Chen Jinjiang Jiang Jinbao Wang Zhouhaoran Chen Ruoxuan Liu Qiaoxue Huang Bo Tang Jin Yao Qiang Wei |
| author_sort | Qiyou Wu |
| collection | DOAJ |
| description | BackgroundTo evaluate unilateral systematic biopsy (SB) combined with targeted biopsy (TB) and assess its diagnostic accuracy in a real-world, single-centre setting.MethodsPatients with ≥1 MRI lesion who underwent both transperineal 12-core and 3-core TB were enrolled in this study. Detection rates for total prostate cancer (PCa) and clinically significant PCa (csPCa) were compared between TB, unilateral SB+TB, and SB+TB. Pathological consistency was assessed using the kappa test, and logistic regression was used to identify potential predictors.ResultsA total of 250 men were enrolled, of which 126 (50.4%) and 103 (41.2%) exhibited total PCa and csPCa, respectively. Compared to SB+TB, ipsilateral SB combined with TB (ips-SB+TB) had a comparable csPCa detection rate (99/250 vs 103/250, p=0.125), while fewer clinically insignificant PCa were detected (17/250 vs 23/250, p=0.031). In addition, ips-SB+TB demonstrated superior sensitivity for csPCa (96.1%) with an AUC of 0.98. The ips-SB+TB had a significantly higher positive core rate than SB+TB (472/2244 vs. 563/3744, p<0.001). Moreover, ips-SB+TB also had a high consistency of Gleason grade compared to SB+TB (Kappa=0.89). In the multi-lesion cohort, ips-SB+TB also had a comparable csPCa detection rate compared to SB+TB (63/128 vs. 67/128, p=0.125).ConclusionsIn conclusion, our study showed that ips-SB+TB was comparable to SB+TB in detecting csPCa. The results of this study provide valuable insight into the potential of ips-SB+TB as an alternative to SB+TB. |
| format | Article |
| id | doaj-art-48eed0e538a44b428d507763aafb00bb |
| institution | DOAJ |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-48eed0e538a44b428d507763aafb00bb2025-08-20T03:07:12ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-08-011510.3389/fonc.2025.15998691599869Assessing the diagnostic accuracy of unilateral systematic biopsy combined with targeted biopsyQiyou Wu0Chunlei He1Xiang Tu2Bo Chen3Jinjiang Jiang4Jinbao Wang5Zhouhaoran Chen6Ruoxuan Liu7Qiaoxue Huang8Bo Tang9Jin Yao10Qiang Wei11Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaWest China School of Medicine, Sichuan University, Chengdu, Sichuan, ChinaWest China School of Medicine, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Nursing, Xiufeng Community Health Service Center, Guilin, Guangxi, ChinaDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaBackgroundTo evaluate unilateral systematic biopsy (SB) combined with targeted biopsy (TB) and assess its diagnostic accuracy in a real-world, single-centre setting.MethodsPatients with ≥1 MRI lesion who underwent both transperineal 12-core and 3-core TB were enrolled in this study. Detection rates for total prostate cancer (PCa) and clinically significant PCa (csPCa) were compared between TB, unilateral SB+TB, and SB+TB. Pathological consistency was assessed using the kappa test, and logistic regression was used to identify potential predictors.ResultsA total of 250 men were enrolled, of which 126 (50.4%) and 103 (41.2%) exhibited total PCa and csPCa, respectively. Compared to SB+TB, ipsilateral SB combined with TB (ips-SB+TB) had a comparable csPCa detection rate (99/250 vs 103/250, p=0.125), while fewer clinically insignificant PCa were detected (17/250 vs 23/250, p=0.031). In addition, ips-SB+TB demonstrated superior sensitivity for csPCa (96.1%) with an AUC of 0.98. The ips-SB+TB had a significantly higher positive core rate than SB+TB (472/2244 vs. 563/3744, p<0.001). Moreover, ips-SB+TB also had a high consistency of Gleason grade compared to SB+TB (Kappa=0.89). In the multi-lesion cohort, ips-SB+TB also had a comparable csPCa detection rate compared to SB+TB (63/128 vs. 67/128, p=0.125).ConclusionsIn conclusion, our study showed that ips-SB+TB was comparable to SB+TB in detecting csPCa. The results of this study provide valuable insight into the potential of ips-SB+TB as an alternative to SB+TB.https://www.frontiersin.org/articles/10.3389/fonc.2025.1599869/fullprostate cancerprostate biopsymultiparametric magnetic resonance imaging utilizationunilateral index lesionregional biopsy |
| spellingShingle | Qiyou Wu Chunlei He Xiang Tu Bo Chen Jinjiang Jiang Jinbao Wang Zhouhaoran Chen Ruoxuan Liu Qiaoxue Huang Bo Tang Jin Yao Qiang Wei Assessing the diagnostic accuracy of unilateral systematic biopsy combined with targeted biopsy Frontiers in Oncology prostate cancer prostate biopsy multiparametric magnetic resonance imaging utilization unilateral index lesion regional biopsy |
| title | Assessing the diagnostic accuracy of unilateral systematic biopsy combined with targeted biopsy |
| title_full | Assessing the diagnostic accuracy of unilateral systematic biopsy combined with targeted biopsy |
| title_fullStr | Assessing the diagnostic accuracy of unilateral systematic biopsy combined with targeted biopsy |
| title_full_unstemmed | Assessing the diagnostic accuracy of unilateral systematic biopsy combined with targeted biopsy |
| title_short | Assessing the diagnostic accuracy of unilateral systematic biopsy combined with targeted biopsy |
| title_sort | assessing the diagnostic accuracy of unilateral systematic biopsy combined with targeted biopsy |
| topic | prostate cancer prostate biopsy multiparametric magnetic resonance imaging utilization unilateral index lesion regional biopsy |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1599869/full |
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